2008年11月
Effects of treatment on soluble tumour necrosis factor receptor type 1 and 2 in chronic periodontitis
JOURNAL OF CLINICAL PERIODONTOLOGY
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- 巻
- 35
- 号
- 11
- 開始ページ
- 961
- 終了ページ
- 968
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/j.1600-051X.2008.01317.x
- 出版者・発行元
- BLACKWELL PUBLISHING
Aim: We reported that soluble tumour necrosis factor receptor type 2 (sTNFR2)/type 1 (sTNFR1) ratios in gingival crevicular fluid (GCF) decreased as the severity of chronic periodontitis (CP) increased. This study investigated the effects of the periodontal treatment on TNF-alpha, sTNFR1 and R2 in GCF and serum of CP patients.
Material and Methods: Thirty-five serum and 90 GCF samples were obtained from 35 CP patients (23 non-smokers and 12 smokers) at baseline and after treatment. The levels of TNF-alpha, sTNFR1 and R2 in serum and GCF were quantified by enzyme-linked immunosorbant assay.
Results: No significant differences were found in the serum levels of TNF-alpha, sTNFR1 and R2 and the ratio of sTNFR2/R1 between baseline and after treatment. After treatment, sTNFR1 and R2 levels in GCF of non-smokers and smokers were significantly decreased compared with baseline. However, the sTNFR2/R1 ratio was significantly increased (non-smoker: 0.56 +/- 0.03-0.84 +/- 0.03, p < 0.0001; smoker: 0.59 +/- 0.06-0.85 +/- 0.04, p=0.0019). There were no significant differences between non-smoking and smoking CP groups in serum and GCF.
Conclusion: The ratio of sTNFR2/R1 in GCF significantly increased after treatment, and could be related to the clinical state of CP.
Material and Methods: Thirty-five serum and 90 GCF samples were obtained from 35 CP patients (23 non-smokers and 12 smokers) at baseline and after treatment. The levels of TNF-alpha, sTNFR1 and R2 in serum and GCF were quantified by enzyme-linked immunosorbant assay.
Results: No significant differences were found in the serum levels of TNF-alpha, sTNFR1 and R2 and the ratio of sTNFR2/R1 between baseline and after treatment. After treatment, sTNFR1 and R2 levels in GCF of non-smokers and smokers were significantly decreased compared with baseline. However, the sTNFR2/R1 ratio was significantly increased (non-smoker: 0.56 +/- 0.03-0.84 +/- 0.03, p < 0.0001; smoker: 0.59 +/- 0.06-0.85 +/- 0.04, p=0.0019). There were no significant differences between non-smoking and smoking CP groups in serum and GCF.
Conclusion: The ratio of sTNFR2/R1 in GCF significantly increased after treatment, and could be related to the clinical state of CP.
- リンク情報
- ID情報
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- DOI : 10.1111/j.1600-051X.2008.01317.x
- ISSN : 0303-6979
- PubMed ID : 18823344
- Web of Science ID : WOS:000260116800007