論文

査読有り
2008年11月

Effects of treatment on soluble tumour necrosis factor receptor type 1 and 2 in chronic periodontitis

JOURNAL OF CLINICAL PERIODONTOLOGY
  • Ikuyo Ikezawa-Suzuki
  • ,
  • Yasuko Shimada
  • ,
  • Hideaki Tai
  • ,
  • Yasutaka Komatsu
  • ,
  • Aya Tanaka
  • ,
  • Hiromasa Yoshie

35
11
開始ページ
961
終了ページ
968
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/j.1600-051X.2008.01317.x
出版者・発行元
BLACKWELL PUBLISHING

Aim: We reported that soluble tumour necrosis factor receptor type 2 (sTNFR2)/type 1 (sTNFR1) ratios in gingival crevicular fluid (GCF) decreased as the severity of chronic periodontitis (CP) increased. This study investigated the effects of the periodontal treatment on TNF-alpha, sTNFR1 and R2 in GCF and serum of CP patients.
Material and Methods: Thirty-five serum and 90 GCF samples were obtained from 35 CP patients (23 non-smokers and 12 smokers) at baseline and after treatment. The levels of TNF-alpha, sTNFR1 and R2 in serum and GCF were quantified by enzyme-linked immunosorbant assay.
Results: No significant differences were found in the serum levels of TNF-alpha, sTNFR1 and R2 and the ratio of sTNFR2/R1 between baseline and after treatment. After treatment, sTNFR1 and R2 levels in GCF of non-smokers and smokers were significantly decreased compared with baseline. However, the sTNFR2/R1 ratio was significantly increased (non-smoker: 0.56 +/- 0.03-0.84 +/- 0.03, p < 0.0001; smoker: 0.59 +/- 0.06-0.85 +/- 0.04, p=0.0019). There were no significant differences between non-smoking and smoking CP groups in serum and GCF.
Conclusion: The ratio of sTNFR2/R1 in GCF significantly increased after treatment, and could be related to the clinical state of CP.

リンク情報
DOI
https://doi.org/10.1111/j.1600-051X.2008.01317.x
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/18823344
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000260116800007&DestApp=WOS_CPL
ID情報
  • DOI : 10.1111/j.1600-051X.2008.01317.x
  • ISSN : 0303-6979
  • PubMed ID : 18823344
  • Web of Science ID : WOS:000260116800007

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