2005年1月
Interleukin-6 (IL-6)-373 A9T11 allele is associated with reduced susceptibility to chronic periodontitis in Japanese subjects and decreased serum IL-6 level
TISSUE ANTIGENS
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 65
- 号
- 1
- 開始ページ
- 110
- 終了ページ
- 114
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/j.1399-0039.2004.00347.x
- 出版者・発行元
- BLACKWELL MUNKSGAARD
We investigated whether interleukin-6 (IL-6) gene polymorphisms could be associated with chronic periodontitis (CP) and serum IL-6 level. One hundred and twelve CP and 77 non-CP Japanese subjects were analyzed for IL-6 -597 (G/A), -572 (C/G), -373 (A(n)T(m)), -190 (C/T), and -174 (G/C) polymorphisms. We could only detect -572 and -373 polymorphisms and found that the frequency and carriage rate of the -373 A9T11 allele were significantly higher in non-CP subjects. Enzyme-linked immunosorbent assay confirmed that the -572 and -373 G[A9T11] haplotypes were associated with lower serum IL-6 level. These findings suggest that IL-6 -373 A9T11 allele could be associated with reduced susceptibility to CP among Japanese subjects and decreased serum IL-6 level.
- リンク情報
- ID情報
-
- DOI : 10.1111/j.1399-0039.2004.00347.x
- ISSN : 0001-2815
- PubMed ID : 15663749
- Web of Science ID : WOS:000226511400009