Papers

Peer-reviewed
Nov, 2011

(-)-Epigallocatechin gallate suppresses the cytotoxicity induced by trichothecene mycotoxins in mouse cultural macrophages

Mycotoxin Research
  • Kei-Ichi Sugiyama
  • ,
  • Mawo Kinoshita
  • ,
  • Yoichi Kamata
  • ,
  • Yuji Minai
  • ,
  • Yoshiko Sugita-Konishi

Volume
27
Number
4
First page
281
Last page
285
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1007/s12550-011-0105-8

Trichothecene mycotoxins are toxic secondary metabolites produced by a number of fungi including Fusarium species, which adversely affect lymphocytes. Deoxynivalenol (DON) and HT-2 toxin (HT-2) belong to the trichothecene group of mycotoxins and the occurrence of cereals and foodstuffs with these compounds are serious health problems. The aim of this study was to examine the effect of (-)-epigallocatechin gallate (EGCG), one of the main components in green tea catechins, on DON- or HT-2-induced cytotoxicity in mouse macrophages. EGCG had protective effects against the trichothecene-induced cytotoxicities of both mycotoxins. Additionally, EGCG suppressed the DON-induced activation of caspase-3/7, which is an indicator of apoptosis. These results indicate that EGCG might be useful in protection against DON- or HT-2-induced cell death, suggesting that EGCG could contribute to reducing the toxicities of trichothecenes. © 2011 Society for Mycotoxin Research and Springer.

Link information
DOI
https://doi.org/10.1007/s12550-011-0105-8
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23605930
ID information
  • DOI : 10.1007/s12550-011-0105-8
  • ISSN : 0178-7888
  • ISSN : 1867-1632
  • Pubmed ID : 23605930
  • SCOPUS ID : 81855217560

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