2019年1月
Genome-wide association study identifies a novel locus associated with psychological distress in the Japanese population
Translational Psychiatry
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- 巻
- 9
- 号
- 1
- 開始ページ
- 52
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/s41398-019-0383-z
Major depressive disorder (MDD) is a common and disabling psychiatric disorder. A recent mega analysis of genome-wide association studies (GWASs) identified 44 loci associated with MDD, though most of the genetic etiologies of the MDD/psychological distress remain unclear. To further understand the genetic basis of MDD/psychological distress, we conducted a GWAS in East Asia with more than 10,000 participants of Japanese ancestry who had enrolled in a direct-to-consumer genetic test. After quality control on the genotype data, 10,330 subjects with a total of 8,567,708 imputed SNPs were eligible for the analysis. The participants completed a self-administered questionnaire on their past medical history and health conditions that included the 6-item Kessler screening scale (K6 scale) for psychological distress (cut-off point of 5) and past medical history of MDD, resulting in 3981 subjects assigned to “psychologically distressed group” [cases], and the remaining 6349 subjects were assigned to the “non-psychologically distressed group” [controls]. In this GWAS, we found an association with genome-wide significance at rs6073833 (P = 7.60 × 10−9) in 20q13.12. This is, to the best of our knowledge, the first large-scale GWAS for psychological distress using data from direct-to-consumer (DTC) genetic tests in a population of non-European-ancestry, and the present study thus detected a novel locus significantly associated with psychological distress in the Japanese population.
- リンク情報
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- DOI
- https://doi.org/10.1038/s41398-019-0383-z
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/30705256
- URL
- https://www.nature.com/articles/s41398-019-0383-z 本文へのリンクあり
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85060932944&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85060932944&origin=inward
- ID情報
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- DOI : 10.1038/s41398-019-0383-z
- eISSN : 2158-3188
- PubMed ID : 30705256
- SCOPUS ID : 85060932944