論文

査読有り 筆頭著者 国際誌
2021年2月16日

Plasma Xanthine Oxidoreductase Activity Is Associated with a High Risk of Cardiovascular Disease in a General Japanese Population

International Journal of Environmental Research and Public Health
  • Yuka Kotozaki
  • Mamoru Satoh
  • Kozo Tanno
  • Hideki Ohmomo
  • Ryo Otomo
  • Fumitaka Tanaka
  • Takahito Nasu
  • Satoru Taguchi
  • Hiroto Kikuchi
  • Takamasa Kobayashi
  • Atsushi Shimizu
  • Kiyomi Sakata
  • Jiro Hitomi
  • Kenji Sobue
  • Makoto Sasaki
  • 全て表示

18
4
開始ページ
1894
終了ページ
1894
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/ijerph18041894
出版者・発行元
{MDPI} {AG}

The purpose of this study was to investigate the association between xanthine oxidoreductase (XOR) activity and a high risk of cardiovascular disease (CVD) in a general Japanese population. The Iwate Tohoku Medical Megabank Organization pooled individual participant data from a general population-based cohort study in Iwate prefecture. The cardiovascular risk was calculated using the Framingham risk score (FRS). A total of 1605 of the 1631 participants (98.4%) had detectable XOR activity. Multiple regression analysis demonstrated that XOR activity was independently associated with body mass index (β = 0.26, p < 0.001), diabetes (β = 0.09, p < 0.001), dyslipidemia (β = 0.08, p = 0.001), and uric acid (β = 0.13, p < 0.001). Multivariate analysis showed that the highest quartile of XOR activity was associated with a high risk for CVD (FRS ≥15) after adjustment for baseline characteristics (OR 2.93, 95%CI 1.16–7.40). The area under the receiver operating characteristic curves of the FRS with XOR activity was 0.81 (p = 0.008). XOR activity is associated with a high risk for CVD, suggesting that high XOR activity may indicate cardiovascular risk in a general Japanese population.

リンク情報
DOI
https://doi.org/10.3390/ijerph18041894
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33669298
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920066
URL
https://www.mdpi.com/1660-4601/18/4/1894
ID情報
  • DOI : 10.3390/ijerph18041894
  • eISSN : 1660-4601
  • ORCIDのPut Code : 88866275
  • PubMed ID : 33669298
  • PubMed Central 記事ID : PMC7920066

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