2007年4月
Acupuncture stimulation to the sacral segment affects state of vigilance in rats
NEUROSCIENCE RESEARCH
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- 巻
- 57
- 号
- 4
- 開始ページ
- 531
- 終了ページ
- 537
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.neures.2006.12.011
- 出版者・発行元
- ELSEVIER IRELAND LTD
The effects of acupuncture stimulation to the sacral segment on electroencephalograms (EEGs) and activity of locus coeruleus (LC) neurons were examined in urethane-anesthetized rats. In 71 of 112 trials, when EEGs displayed small amplitude and high frequency, stimulation to the sacral segment-induced large amplitude and slow EEGs with a latency of < 450 s and duration ranged from 32 s to > 42 min. Stimulus-induced EEGs comprised significant increases in delta power and significant decreases in theta and beta powers. After intraperitoneal administration of bicuculline, stimulation to the sacral segment failed to induce changes in EEG pattern. Firing rate of noradrenergic LC neurons decreased significantly from 2.9 +/- 1.5 to 1.1 +/- 0.8 Hz (n = 11, p < 0.001). Decreased neuronal activity exhibited close relationships with increased EEG amplitude. These results suggest that acupuncture stimulation to the sacral segment changes the state of animals from light anesthesia to deep anesthesia, and that this change is mediated by GABAergic systems suppressing the activity of noradrenergic LC neurons. (c) 2007 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.neures.2006.12.011
- CiNii Articles
- http://ci.nii.ac.jp/naid/10024413906
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/17267062
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000245766000007&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1016/j.neures.2006.12.011
- ISSN : 0168-0102
- CiNii Articles ID : 10024413906
- PubMed ID : 17267062
- Web of Science ID : WOS:000245766000007