小栁直人 (Naoto Koyanagi) - マイポータル

基本情報

所属: 東京大学医科学研究所感染・免疫部門ウイルス病態制御分野

研究者番号: 90738121
J-GLOBAL ID: 201801013022891726
researchmap会員ID: B000323833

研究分野

ライフサイエンス / ウイルス学 /

論文

Identification of viral activators of the HSV-2 UL13 protein kinase.

Naoto Koyanagi, Kosuke Takeshima, Saori Shio, Yuhei Maruzuru, Akihisa Kato, Yasushi Kawaguchi

Journal of virology 99(10) e0116525 2025年10月23日
Impact of the changes in substrate specificity of herpes simplex virus 1 protein kinase Us3 on viral infection in vitro and in vivo.

Saori Shio, Akihisa Kato, Jurika Kawasaki, Kousuke Takeshima, Yuhei Maruzuru, Naoto Koyanagi, Hayato Harima, Yasushi Kawaguchi

Journal of virology 99(7) e0040025 2025年7月22日
Herpes simplex virus 1 evades APOBEC1-mediated immunity via its uracil-DNA glycosylase in mice

Akihisa Kato, Hayato Harima, Yuji Tsunekawa, Manabu Igarashi, Kouichi Kitamura, Kousho Wakae, Tomoaki Nishiyama, Satoru Morimoto, Toru Suzuki, Hiroko Kozuka-Hata …

Nature Microbiology 2025年6月3日
Direct relationship between protein expression and progeny yield of herpes simplex virus 1

Moeka Nobe, Yuhei Maruzuru, Kosuke Takeshima, Fumio Maeda, Hideo Kusano, Raiki Yoshimura, Takara Nishiyama, Hyeongki Park, Yoshitaka Kozaki, Shingo Iwami …

mBio 2025年5月5日
Regulatory mimicry of cyclin-dependent kinases by a conserved herpesvirus protein kinase

Naoto Koyanagi, Kowit Hengphasatporn, Akihisa Kato, Moeka Nobe, Kosuke Takeshima, Yuhei Maruzuru, Katsumi Maenaka, Yasuteru Shigeta, Yasushi Kawaguchi

Proceedings of the National Academy of Sciences of the United States of America 122(16) e2500264122 2025年4月16日査読有り
Impact of the interaction between herpes simplex virus 1 ICP22 and FACT on viral gene expression and pathogenesis

Shaocong Liu, Yuhei Maruzuru, Kosuke Takeshima, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi

Journal of Virology 2024年7月17日
MYBBP1A is required for efficient replication and gene expression of herpes simplex virus 1.

Moeka Nobe, Yuhei Maruzuru, Kosuke Takeshima, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi

Microbiology and immunology 68(4) 148-154 2024年4月
Evasion of APOBEC1-mediated Intrinsic Immunity by a Herpesvirus Uracil DNA Glycosylase Is a Determinant of Viral Encephalitis

Akihisa Kato, Hayato Harima, Yuji Tsunekawa, Manabu Igarashi, Kouichi Kitamura, Kousho Wakae, Hiroko Kozuka-Hata, Masaaki Oyama, Mizuki Watanabe, Kousuke Takeshima …

2023年6月23日
Establishment of a system to quantify wild-type herpes simplex virus-induced cell-cell fusion reveals a role of N-glycosylation of HSV-1 envelope glycoprotein B in cell-cell fusion.

Ayano Fukui, Yuhei Maruzuru, Kosuke Takeshima, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi

Microbiology and immunology 67(3) 114-119 2023年3月
Dual Impacts of a Glycan Shield on the Envelope Glycoprotein B of HSV-1: Evasion from Human Antibodies In Vivo and Neurovirulence

Ayano Fukui, Yuhei Maruzuru, Shiho Ohno, Moeka Nobe, Shuji Iwata, Kosuke Takeshima, Naoto Koyanagi, Akihisa Kato, Shinobu Kitazume, Yoshiki Yamaguchi …

2022年12月13日
Redundant and Specific Roles of A-Type Lamins and Lamin B Receptor in Herpes Simplex Virus 1 Infection.

Kosuke Takeshima, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi

Journal of virology e0142922 2022年11月30日
Role of the Orphan Transporter SLC35E1 in the Nuclear Egress of Herpes Simplex Virus 1.

Fumio Maeda, Akihisa Kato, Kosuke Takeshima, Misato Shibazaki, Ryota Sato, Takuma Shibata, Kensuke Miyake, Hiroko Kozuka-Hata, Masaaki Oyama, Eigo Shimizu …

Journal of virology 96(10) e0030622 2022年4月27日
Role of the arginine cluster in the disordered domain of Herpes Simplex Virus 1 UL34 for the recruitment of ESCRT-III for viral primary envelopment.

Jun Arii, Kosuke Takeshima, Yuhei Maruzuru, Naoto Koyanagi, Yoshitaka Nakayama, Akihisa Kato, Yasuko Mori, Yasushi Kawaguchi

Journal of virology JVI0170421 2021年11月3日
Prolonged high-intensity exercise induces fluctuating immune responses to herpes simplex virus infection via glucocorticoids

Akimasa Adachi, Tetsuya Honda, Teruki Dainichi, Gyohei Egawa, Yosuke Yamamoto, Takashi Nomura, Saeko Nakajima, Atsushi Otsuka, Masamitsu Maekawa, Nariyasu Mano …

Journal of Allergy and Clinical Immunology 148(6) 1575-1588 2021年5月査読有り
Virus-infection in cochlear supporting cells induces audiosensory receptor hair cell death by TRAIL-induced necroptosis.

Yushi Hayashi, Hidenori Suzuki, Wataru Nakajima, Ikuno Uehara, Atsuko Tanimura, Toshiki Himeda, Satoshi Koike, Tatsuya Katsuno, Shin-Ichiro Kitajiri, Naoto Koyanagi …

PloS one 16(11) e0260443 2021年
Role of the DNA Binding Activity of Herpes Simplex Virus 1 VP22 in Evading AIM2-Dependent Inflammasome Activation Induced by the Virus

Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi

Journal of Virology 2020年12月9日
ESCRT-III controls nuclear envelope deformation induced by progerin

Jun Arii, Fumio Maeda, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasuko Mori, Yasushi Kawaguchi

Scientific Reports 10(1) 2020年12月1日
Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics

Akihisa Kato, Shungo Adachi, Shuichi Kawano, Kousuke Takeshima, Mizuki Watanabe, Shinobu Kitazume, Ryota Sato, Hideo Kusano, Naoto Koyanagi, Yuhei Maruzuru …

Nature Communications 11(1) 2020年12月1日
Evasion of the Cell-Mediated Immune Response by Alphaherpesviruses

Naoto Koyanagi, Yasushi Kawaguchi

Viruses 12(12) 1354-1354 2020年11月26日査読有り
Prohibitin-1 Contributes to Cell-to-Cell Transmission of Herpes Simplex Virus 1 via the MAPK/ERK Signaling Pathway

Mizuki Watanabe, Jun Arii, Kosuke Takeshima, Ayano Fukui, Masayuki Shimojima, Hiroko Kozuka-Hata, Masaaki Oyama, Takeharu Minamitani, Teruhito Yasui, Yuji Kubota …

Journal of Virology 95(3) 2020年11月11日

もっとみる

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単純ヘルペス脳炎発症機構の解明

日本学術振興会科学研究費助成事業基盤研究(C) 2023年4月 - 2026年3月

小柳直人
HSV-2の新規CTL回避機構の解明

日本学術振興会科学研究費助成事業若手研究 2021年4月 - 2023年3月

小柳直人
単純ヘルペスウイルスのNK細胞回避機構の解明

日本学術振興会科学研究費助成事業若手研究若手研究 2018年4月 - 2020年3月

小柳直人

小栁直人

基本情報

研究分野

論文

共同研究・競争的資金等の研究課題

メニュー

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