論文

査読有り
2015年4月

Phosphorylation of myosin II regulatory light chain by ZIP kinase is responsible for cleavage furrow ingression during cell division in mammalian cultured cells

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
  • Kosuke Hosoba
  • ,
  • Satoshi Komatsu
  • ,
  • Mitsuo Ikebe
  • ,
  • Manato Kotani
  • ,
  • Xiao Wenqin
  • ,
  • Taro Tachibana
  • ,
  • Hiroshi Hosoya
  • ,
  • Kozue Hamao

459
4
開始ページ
686
終了ページ
691
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.bbrc.2015.03.005
出版者・発行元
ACADEMIC PRESS INC ELSEVIER SCIENCE

Zipper-interacting protein kinase (ZIPK) is known to regulate several functions such as apoptosis, smooth muscle contraction, and cell migration. While exogenously expressed GFP-ZIPK localizes to the cleavage furrow, role of ZIPK in cytokinesis is obscure. Here, we show that ZIPK is a major MRLC kinase during mitosis. Moreover, ZIPK siRNA-mediated knockdown causes delay of cytokinesis. The delay in cytokinesis of ZINC-knockdown cells was rescued by the exogenous diphosphorylation-mimicking MRLC mutant. Taken together, these findings suggest that ZIPK plays a role in the progression and completion of cytokinesis through MRLC phosphorylation. (C) 2015 Elsevier Inc. All rights reserved.

Web of Science ® 被引用回数 : 3

リンク情報
DOI
https://doi.org/10.1016/j.bbrc.2015.03.005
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25769953
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000352922200021&DestApp=WOS_CPL

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