論文

国際誌
2021年

Prolonged overall treatment time negatively affects the outcomes of stereotactic body radiotherapy for early-stage non-small-cell lung cancer: A propensity score-weighted, single-center analysis.

PloS one
  • Toshiki Ikawa
  • Takahiro Tabuchi
  • Koji Konishi
  • Masahiro Morimoto
  • Takero Hirata
  • Naoyuki Kanayama
  • Kentaro Wada
  • Masayasu Toratani
  • Sumiyo Okawa
  • Kazuhiko Ogawa
  • Teruki Teshima
  • 全て表示

16
6
開始ページ
e0253203
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1371/journal.pone.0253203

Previous studies have reported conflicting results for the effect of overall treatment time with stereotactic body radiotherapy on tumor control in early-stage non-small-cell lung cancer. To examine this effect, we conducted a propensity score-weighted, retrospective, observational study at a single institution. We analyzed the data of 200 patients with early-stage non-small-cell lung cancer who underwent stereotactic body radiotherapy (48 Gy in 4 fractions) at our institution between January 2007 and October 2013. Patients were grouped into consecutive (overall treatment time = 4-5 days, n = 116) or non-consecutive treatment groups (overall treatment time = 6-10 days, n = 84). The outcomes of interest were local control and overall survival. The Cox regression model was used with propensity score and inverse probability of treatment weighting. The median overall treatment times in the consecutive and non-consecutive groups were 4 and 6 days, respectively. The 5-year local control and overall survival rates in the consecutive vs. the non-consecutive group were 86.3 vs. 77.2% and 55.5 vs. 51.8%, respectively. After propensity score weighting, consecutive stereotactic body radiotherapy was associated with positive local control (adjusted hazard ratio 0.30, 95% confidence interval 0.14-0.65; p = 0.002) and overall survival (adjusted hazard ratio 0.56, 95% confidence interval 0.34-0.91; p = 0.019) benefits. The prolonged overall treatment time of stereotactic body radiotherapy treatment negatively affected the outcomes of patients with early-stage non-small-cell lung cancer. To our knowledge, this is the first study to show that in patients with early-stage non-small-cell lung cancer treated with the same dose-fractionation regimen, consecutive stereotactic body radiotherapy has a more beneficial effect on tumor control than non-consecutive stereotactic body radiotherapy.

リンク情報
DOI
https://doi.org/10.1371/journal.pone.0253203
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34143851
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213186
ID情報
  • DOI : 10.1371/journal.pone.0253203
  • PubMed ID : 34143851
  • PubMed Central 記事ID : PMC8213186

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