2017年
Adult-onset Chronic Recurrent Multifocal Osteomyelitis with High Intensity of Muscles Detected by Magnetic Resonance Imaging, Successfully Controlled with Tocilizumab
INTERNAL MEDICINE
- 巻
- 56
- 号
- 17
- 開始ページ
- 2353
- 終了ページ
- 2360
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.2169/internalmedicine.8473-16
- 出版者・発行元
- JAPAN SOC INTERNAL MEDICINE
Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disorder that generally occurs in children and predominantly affects the long bones with marginal sclerosis. We herein report two cases of adult-onset CRMO involving the tibial diaphysis bilaterally, accompanied by polyarthritis. Magnetic resonance imaging (MRI) showed both tibial osteomyelitis and high intensity of the extensive lower leg muscles. Anti-interleukin-6 therapy with tocilizumab (TCZ) effectively controlled symptoms and inflammatory markers in both patients. High intensity of the lower leg muscles detected by MRI also improved. These cases demonstrate that CRMO should be included in the differential diagnosis of adult patients with bone pain, inflammation, and high intensity of the muscles detected by MRI. TCZ may therefore be an effective therapy for muscle inflammation of CRMO.
- リンク情報
- ID情報
-
- DOI : 10.2169/internalmedicine.8473-16
- ISSN : 0918-2918
- eISSN : 1349-7235
- PubMed ID : 28794369
- Web of Science ID : WOS:000411760900021