論文

査読有り
2017年

Adult-onset Chronic Recurrent Multifocal Osteomyelitis with High Intensity of Muscles Detected by Magnetic Resonance Imaging, Successfully Controlled with Tocilizumab

INTERNAL MEDICINE
  • Hiroe Sato
  • Yoko Wada
  • Eriko Hasegawa
  • Yukiko Nozawa
  • Takeshi Nakatsue
  • Tomoyuki Ito
  • Takeshi Kuroda
  • Takako Saeki
  • Hajime Umezu
  • Yoshiki Suzuki
  • Masaaki Nakano
  • Ichiei Narita
  • 全て表示

56
17
開始ページ
2353
終了ページ
2360
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2169/internalmedicine.8473-16
出版者・発行元
JAPAN SOC INTERNAL MEDICINE

Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disorder that generally occurs in children and predominantly affects the long bones with marginal sclerosis. We herein report two cases of adult-onset CRMO involving the tibial diaphysis bilaterally, accompanied by polyarthritis. Magnetic resonance imaging (MRI) showed both tibial osteomyelitis and high intensity of the extensive lower leg muscles. Anti-interleukin-6 therapy with tocilizumab (TCZ) effectively controlled symptoms and inflammatory markers in both patients. High intensity of the lower leg muscles detected by MRI also improved. These cases demonstrate that CRMO should be included in the differential diagnosis of adult patients with bone pain, inflammation, and high intensity of the muscles detected by MRI. TCZ may therefore be an effective therapy for muscle inflammation of CRMO.

リンク情報
DOI
https://doi.org/10.2169/internalmedicine.8473-16
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28794369
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000411760900021&DestApp=WOS_CPL
ID情報
  • DOI : 10.2169/internalmedicine.8473-16
  • ISSN : 0918-2918
  • eISSN : 1349-7235
  • PubMed ID : 28794369
  • Web of Science ID : WOS:000411760900021

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