桜井光一 (Koichi Sakurai) - マイポータル

基本情報

所属: 北海道科学大学薬学部生命科学分野教授
: (兼任)大学院薬学研究科生物薬学専攻教授

学位: 博士(薬学)(北海道薬科大学)

J-GLOBAL ID: 200901058470659005
researchmap会員ID: 1000060135

研究キーワード

研究分野

経歴

1997年 - 2002年

北海道薬科大学講師
1997年 - 2002年

Assitant professor, Faculty of Pharmacy,
1996年 - 1997年

マウントサイナイ医科大学、リサーチアソシエート(USA)
1996年 - 1997年

Research associate, Faculty of Medicine,
1982年 - 1997年

北海道薬科大学薬学部助手
1982年 - 1997年

Assistant, Faculty of Pharmacy, Hokkaido College
Hokkaido College of Phrmacy
Mount Sinai School of Medicine
of Pharmacy

学歴

- 1982年

北海道薬科大学, 薬学部, 生物薬学科
- 1982年

北海道薬科大学

委員歴

2021年3月 - 2022年2月

日本薬学会北海道支部, 支部長

受賞

論文

Catalase is required for peroxisome maintenance during adipogenesis.

Yuuki Nitta, Sanae Muraoka-Hirayama, Koichi Sakurai

Biochimica et biophysica acta. Molecular and cell biology of lipids 1865(8) 158726-158726 2020年8月
Loss of Mitochondrial DNA by Gemcitabine Triggers Mitophagy and Cell Death.

Akihiro Inamura, Sanae Muraoka-Hirayama, Koichi Sakurai

Biological & pharmaceutical bulletin 42(12) 1977-1987 2019年
[Linezolid-induced Apoptosis through Mitochondrial Damage and Role of Superoxide Dismutase-1 in Human Monocytic Cell Line U937].

Satoshi Fujii, Sanae Muraoka, Atsushi Miyamoto, Koichi Sakurai

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 138(1) 73-81 2018年
Increase of Anti-oxidative Capacity during Differentiation of 3T3-L1 Preadipocytes into Adipocytes.

Sanae Muraoka, Yuuki Nitta, Taiki Yamada, Yuusuke Sakuma, Aoi Ichimura, Koichi Sakurai

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 137(9) 1137-1145 2017年
Hemin Protects U937 Cells from Oxidative Stress via Glutathione Synthesis

Yoshimi Satoh, Kyohei Oyama, Koichi Sakurai

Journal of Biophysical Chemistry 05(02) 13-23 2014年
Involvement of phosphatidylinositol 3-kinase/Akt pathway in gemcitabine-induced apoptosis-like cell death in insulinoma cell line INS-1

Hironori Motoshige, Kyohei Oyama, Kiyoshi Takahashi, Koichi Sakurai

Biological and Pharmaceutical Bulletin 35(11) 1932-1940 2012年11月査読有り
Hydrogen peroxide induces cell cycle arrest in cardiomyoblast H9c2 cells, which is related to hypertrophy

Kyohei Oyama, Kiyoshi Takahashi, Koichi Sakurai

Biological and Pharmaceutical Bulletin 34(4) 501-506 2011年4月査読有り
Involvement of mitochondrial swelling in cytochrome c release from mitochondria treated with calcium and Alloxan

Takuya Ichimura, Mika Ito, Kiyoshi Takahashi, Kyohei Oyama, Koichi Sakurai

Journal of Biophysical Chemistry 02(01) 10-18 2011年
Antioxidative action of N-a-tosyl-L-lysine chloromethyl ketone prevents death of glutathione-depleted cardiomyocytes induced by hydrogen peroxide

Kiyoshi Takahashi, Kyohei Oyama, Hironori Motoshige, Koichi Sakurai

Journal of Biophysical Chemistry 01(03) 164-171 2010年
Cardiomyocyte H9c2 cells exhibit differential sensitivity to intracellular reactive oxygen species generation with regard to their hypertrophic vs death responses to exogenously added hydrogen peroxide

Kyohei Oyama, Kiyoshi Takahashi, Koichi Sakurai

Journal of Clinical Biochemistry and Nutrition 45(3) 361-369 2009年11月
Alloxan radical-induced generation of reactive oxygen species in the reaction system of alloxan with ascorbate

M Katoh, K Sakurai, Y Fujimoto

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 122(10) 831-839 2002年10月査読有り
STUDIES ON BIOLOGICAL DAMAGE BY ACTIVE OXYGENS .3. GENERATION OF HYDROXYL RADICAL AND INHIBITION OF INSULIN RELEASE IN HYPOXANTHINE XANTHINE-OXIDASE SYSTEM IN THE PRESENCE OF PANCREATIC-ISLET CELLS

K SAKURAI, T OGISO

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 109(2) 102-106 1989年2月査読有り
STUDIES ON BIOLOGICAL DAMAGE BY ACTIVE OXYGENS .2. INHIBITION OF INSULIN RELEASE FROM ISOLATED PANCREATIC-ISLETS BY EXPOSURE TO O-2-GENERATING SYSTEM OF HYPOXANTHINE XANTHINE-OXIDASE

K SAKURAI, Y OGAWA, T MIURA, T OGISO

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 108(2) 150-155 1988年2月査読有り
STUDIES ON BIOLOGICAL DAMAGE BY ACTIVE OXYGEN .1. PROTECTIVE EFFECT OF VARIOUS HYDROXYL RADICAL SCAVENGERS AGAINST ALLOXAN-INDUCED DIABETES

K SAKURAI, T MIURA, T OGISO

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 106(11) 1034-1039 1986年11月査読有り

MISC

Protective mechanism of haemoglobin against cell damages in alloxan and GSH system

Koichi Sakurai, Toshiaki Mogi

FREE RADICAL BIOLOGY AND MEDICINE 96 S64-S64 2016年7月
Requirement of intracellular free thiols for hydrogen peroxide-induced hypertrophy in cardiomyocytes

H Tanaka, K Sakurai, K Takahashi, Y Fujimoto

JOURNAL OF CELLULAR BIOCHEMISTRY 89(5) 944-955 2003年8月
アロキサンとアスコビン酸の反応系におけるアロキサンラジカル誘導活性酸素生成

薬学雑誌 122(10) 831-839 2002年10月
糖尿病発症におけるミトコンドリア機能障害とアポトーシスの関与

道薬誌 19(8) 3-8 2002年
Apoptosis and mitochondrial damage in INS-1 cells treated with alloxan

K Sakurai, M Katoh, K Someno, Y Fujimoto

BIOLOGICAL & PHARMACEUTICAL BULLETIN 24(8) 876-882 2001年8月
Alloxan-induced mitochondrial permeability transition triggered by calcium, thiol oxidation, and matrix ATP

K Sakurai, M Katoh, Y Fujimoto

JOURNAL OF BIOLOGICAL CHEMISTRY 276(29) 26942-26946 2001年7月
Apoptosis and Mitochondrial Damages in INS-I Cells Treatecl with Alloxan

Biological & Pharmaceutical Bulletin 24(8) 876-882 2001年
Alloxan-induced Mitochondrial Permeability Transition Triggered by Calcium, Thiol Oxidation, and Matrix ATP

The Journal of Biological Chemistry 276(29) 26942-26946 2001年
Mitochondrial permeability transition induced by 1-hydroxyethyl radical

K Sakurai, DA Stoyanovsky, Y Fujimoto, AI Cederbaum

FREE RADICAL BIOLOGY AND MEDICINE 28(2) 273-280 2000年1月
Mitochondrial damage associated with apoptosis in INS-1 cells treated with alloxan

K Sakurai, M Katoh, Y Fujimoto

FREE RADICAL BIOLOGY AND MEDICINE 27 S115-S115 1999年
Oxidative stress and cytotoxicity induced by ferric-nitrilotriacetate in HepG2 cells that express cytochrome P450 2E1

K Sakurai, AI Cederbaum

MOLECULAR PHARMACOLOGY 54(6) 1024-1035 1998年12月
Inhibition of microsomal lipid peroxidation by baicalein: A possible formation of an iron-baicalein complex

DY Gao, K Sakurai, M Katoh, JM Chen, T Ogiso

BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL 39(2) 215-225 1996年5月
PROTECTION BY BAICALEIN AGAINST ASCORBIC ACID-INDUCED LIPID-PEROXIDATION OF RAT-LIVER MICROSOMES

DY GAO, K SAKURAI, JM CHEN, T OGISO

RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY 90(1) 103-114 1995年10月
EFFECT OF FERRITIN ON LAMBDA-DNA STRAND BREAKS IN THE REACTION SYSTEM OF ALLOXAN PLUS NADPH-CYTOCHROME P450 REDUCTASE - FERRITINS ROLE IN DIABETOGENIC ACTION OF ALLOXAN

K SAKURAI, T OGISO

BIOLOGICAL & PHARMACEUTICAL BULLETIN 18(2) 262-266 1995年2月
アロキサンのλDNA鎖切断作用に対するグルタチオンの影響

過酸化脂質研究 19(2) 98-102 1995年
Effect of glutathione λDNA Strand Breaks by Alloxan

Lipid peroxide Research 19(2) 98-102 1995年
GENERATION OF ALLOXAN RADICAL IN RAT ISLET CELLS - PARTICIPATION OF NADPH - CYTOCHROME-P-450 REDUCTASE

K SAKURAI, T OGISO

BIOLOGICAL & PHARMACEUTICAL BULLETIN 17(11) 1451-1455 1994年11月
A ROLE OF IRON IN LAMBDA-DNA STRAND BREAKS IN THE REACTION SYSTEM OF ALLOXAN WITH REDUCED GLUTATHIONE - IRON(III) BINDING TO THE DNA

K SAKURAI, K HAGA, T OGISO

BIOLOGICAL & PHARMACEUTICAL BULLETIN 17(2) 227-231 1994年2月
EFFECT OF GLUTATHIONE ON LAMBDA-DEOXYRIBONUCLEIC ACID STRAND BREAKS IN THE REACTION SYSTEM OF GLUTATHIONE ALLOXAN IN THE PRESENCE OF FE-3+-ETHYLENEDIAMINETETRAACETIC ACID

K SAKURAI, K HAGA, T OGISO

CHEMICAL & PHARMACEUTICAL BULLETIN 40(8) 2147-2150 1992年8月
ENZYMATIC GENERATION OF ALLOXAN RADICALS IN RAT-LIVER MICROSOMES - POSSIBLE PARTICIPATION OF REDUCED NICOTINAMIDE ADENINE-DINUCLEOTIDE PHOSPHATE (NADPH)-CYTOCHROME-P-450 REDUCTASE

K SAKURAI, K HAGA, T OGISO

CHEMICAL & PHARMACEUTICAL BULLETIN 40(2) 432-435 1992年2月

もっとみる

桜井光一

基本情報

研究キーワード

研究分野

経歴

学歴

委員歴

受賞

論文

MISC

所属学協会

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