澤田光平 (Kohei Sawada) - マイポータル

基本情報

所属: 一般社団法人日本薬理評価機構チーフサイエンティックアドバイザー

学位: 博士(東京大学大学院)

J-GLOBAL ID: 201801020679996613
researchmap会員ID: B000327775

研究キーワード

研究分野

ライフサイエンス / 薬系衛生、生物化学 / 薬理

経歴

2017年4月 - 現在

一般社団法人日本薬理評価機構, チーフサイエンティックアドバイザー
2018年10月 - 2021年10月

東京大学大学院薬学系研究科, 化学物質安全性評価システム構築社会連携講座, 客員教授
2018年3月 - 2018年9月

東京大学大学院薬学系研究科, ヒト細胞創薬学寄付講座, 客員教授
2017年9月 - 2018年3月

東京大学大学院薬学系研究科, ヒト細胞創薬学寄付講座, 特任教授
1983年4月 - 2017年9月

エーザイ（株）
2009年4月 - 2017年3月

筑波大学大学院人間総合科学研究科連携大学院, 分子創薬学, 教授
2004年4月 - 2009年3月

筑波大学大学院人間総合科学研究科連携大学院, 分子創薬学, 準教授
1984年4月 - 1992年3月

東京医科歯科大学難治疾患研究所, 循環器病部門

委員歴

2017年4月 - 現在

日本安全性薬理研究会, 理事
2012年4月 - 2017年3月

日本安全性薬理研究会, 会長

論文

Chloroquine and hydroxychloroquine provoke arrhythmias at concentrations higher than those clinically used to treat COVID-19: A simulation study.

Jun-Ichi Okada, Takashi Yoshinaga, Takumi Washio, Kohei Sawada, Seiryo Sugiura, Toshiaki Hisada

Clinical and translational science 14(3) 1092-1100 2021年5月
Machine-learning-based quality control of contractility of cultured human-induced pluripotent stem-cell-derived cardiomyocytes.

Ken Orita, Kohei Sawada, Nobuyoshi Matsumoto, Yuji Ikegaya

Biochemical and Biophysical Research Communications 2020年4月4日査読有り
Development of torsadogenic risk assessment using human induced pluripotent stem cell-derived cardiomyocytes: Japan iPS Cardiac Safety Assessment (JiCSA) update.

Kanda Y, Yamazaki D, Osada T, Yoshinaga T, Sawada K

Journal of pharmacological sciences 138(4) 233-239 2018年12月査読有り
Arrhythmic hazard map for a 3D whole-ventricle model under multiple ion channel block.

Jun-Ichi Okada, Takashi Yoshinaga, Junko Kurokawa, Takumi Washio, Tetsushi Furukawa, Kohei Sawada, Seiryo Sugiura, Toshiaki Hisada

British journal of pharmacology 175(17) 3435-3452 2018年9月査読有り
International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment.

Blinova K, Dang Q, Millard D, Smith G, Pierson J, Guo L, Brock M, Lu HR, Kraushaar U, Zeng H …

Cell reports 24(13) 3582-3592 2018年9月査読有り
Hsp90 inhibitor geldanamycin attenuates the cytotoxicity of sunitinib in cardiomyocytes via inhibition of the autophagy pathway

Takayuki Kimura, Mai Uesugi, Kazuma Takase, Norimasa Miyamoto, Kohei Sawada

TOXICOLOGY AND APPLIED PHARMACOLOGY 329 282-292 2017年8月査読有り
A new paradigm for drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytes

Hiroyuki Ando, Takashi Yoshinaga, Wataru Yamamotoa, Keiichi Asakura, Takaaki Uda, Tomohiko Taniguchi, Atsuko Ojima, Raku Shinkyo, Kiyomi Kikuchi, Tomoharu Osada …

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 84 111-127 2017年3月査読有り
Functional Characterization of Acetylcholine Receptors Expressed in Human Neurons Differentiated from Hippocampal Neural Stem/Progenitor Cells

Kazuyuki Fukushima, Kazuto Yamazaki, Norimasa Miyamoto, Kohei Sawada

JOURNAL OF BIOMOLECULAR SCREENING 21(10) 1065-1074 2016年12月査読有り
Electrophysiological Characteristics of Human iPSC-Derived Cardiomyocytes for the Assessment of Drug-Induced Proarrhythmic Potential

Wataru Yamamoto, Keiichi Asakura, Hiroyuki Ando, Tomohiko Taniguchi, Atsuko Ojima, Takaaki Uda, Tomoharu Osada, Seiji Hayashi, Chieko Kasai, Norimasa Miyamoto …

PLOS ONE 11(12) e0167348 2016年12月査読有り
ヒトiPS細胞由来分化心筋細胞及び多点平面電極法を用いたTdPリスク分類法の開発

安藤博之, 吉永貴志, 山本渉, 朝倉圭一, 谷口智彦, 宇田宗晃, 小島敦子, 長田智治, 林誠治, 葛西智恵子 …

日本毒性学会学術年会 43 P-141 2016年
薬剤誘発性不整脈のリスク評価に関するヒトiPS細胞由来分化心筋細胞の薬理学的検討：I_Kr阻害剤の逆頻度依存的なfield potential duration延長作用と催不整脈マーカーの探索

山本渉, 朝倉圭一, 安藤博之, 谷口智彦, 小島敦子, 宇田宗晃, 長田智治, 林誠治, 葛西智恵子, 宮本憲優 …

日本毒性学会学術年会 43 P-154 2016年
A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm

Bernard Fermini, Jules C. Hancox, Najah Abi-Gerges, Matthew Bridgland-Taylor, Khuram W. Chaudhary, Thomas Colatsky, Krystle Correll, William Crumb, Bruce Damiano, Gul Erdemli …

JOURNAL OF BIOMOLECULAR SCREENING 21(1) 1-11 2016年1月査読有り
Establishment of a Human Neuronal Network Assessment System by Using a Human Neuron/Astrocyte Co-Culture Derived from Fetal Neural Stem/Progenitor Cells

Kazuyuki Fukushima, Yuji Miura, Kohei Sawada, Kazuto Yamazaki, Masashi Ito

JOURNAL OF BIOMOLECULAR SCREENING 21(1) 54-64 2016年1月査読有り
The synthesis and BK channel-opening activity of N-acylaminoalkyloxime derivatives of dehydroabietic acid

Yong-Mei Cui, Xin-Lan Liu, Wen-Ming Zhang, Hai-Xia Lin, Tomohiko Ohwada, Katsutoshi Ido, Kohei Sawada

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26(2) 283-287 2016年1月査読有り
Improvement of acquisition and analysis methods in multi-electrode array experiments with iPS cell-derived cardiomyocytes

Keiichi Asakura, Seiji Hayashi, Atsuko Ojima, Tomohiko Taniguchi, Norimasa Miyamoto, Chiaki Nakamori, Chiho Nagasawa, Tetsuo Kitamura, Tomoharu Osada, Yayoi Honda …

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 75 17-26 2015年9月査読有り
Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator

Jun-ichi Okada, Takashi Yoshinaga, Junko Kurokawa, Takumi Washio, Tetsushi Furukawa, Kohei Sawada, Seiryo Sugiura, Toshiaki Hisada

SCIENCE ADVANCES 1(4) e1400142 2015年5月査読有り
Oscillatory potentials in electroretinogram as an early marker of visual abnormalities in vitamin A deficiency

Dai Kakiuchi, Taisuke Uehara, Motohiro Shiotani, Kyoko Nakano-T, Akiyoshi Suganuma, Toyohiko Aoki, Kazuo Tsukidate, Kohei Sawada

MOLECULAR MEDICINE REPORTS 11(2) 995-1003 2015年2月査読有り
Involvement of the strychnine-sensitive glycine receptor in the anxiolytic effects of GlyT1 inhibitors on maternal separation-induced ultrasonic vocalization in rat pups

Hiroko Komatsu, Yoshiaki Furuya, Kohei Sawada, Takashi Asada

EUROPEAN JOURNAL OF PHARMACOLOGY 746 252-257 2015年1月査読有り
Characterization of Human Hippocampal Neural Stem/Progenitor Cells and Their Application to Physiologically Relevant Assays for Multiple Ionotropic Glutamate Receptors

Kazuyuki Fukushima, Yoshikuni Tabata, Yoichi Imaizumi, Naohiro Kohmura, Michiko Sugawara, Kohei Sawada, Kazuto Yamazaki, Masashi Ito

JOURNAL OF BIOMOLECULAR SCREENING 19(8) 1174-1184 2014年9月査読有り
Novel ATP-Competitive MEK Inhibitor E6201 Is Effective against Vemurafenib-Resistant Melanoma Harboring the MEK1-C121S Mutation in a Preclinical Model

Yusuke Narita, Kiyoshi Okamoto, Megumi Ikemori Kawada, Kazuma Takase, Yukinori Minoshima, Kotaro Kodama, Masao Iwata, Norimasa Miyamoto, Kohei Sawada

MOLECULAR CANCER THERAPEUTICS 13(4) 823-832 2014年4月査読有り

もっとみる

MISC

Drug-Induced Torsadogenic Risk Prediction Using Human iPS Cell-Derived Cardiomyocytes and MEA System (II)

Takashi Yoshinaga, Hiroyuki Ando, Tomohiko Taniguchi, Takaaki Uda, Wataru Yamamoto, Keiichi Asakura, Atsuko Ojima, Raku Shinkyo, Kiyomi Kikuchi, Tomoharu Osada …

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 88 190-190 2017年11月
Electrophysiological and Pharmacological Characterization of Human iPS Cell-Derived Cardiomyocytes As a Model for Predicting the Drug-Induced Arrhythmic Events in Human Hearts

Wataru Yamamoto, Keiichi Asakura, Hiroyuki Ando, Tomohiko Taniguchi, Atsuko Ojima, Takaaki Uda, Tomoharu Osada, Seiji Hayashi, Chieko Kasai, Norimasa Miyamoto …

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 88 189-190 2017年11月
Simultaneous Comparison of Optical Action Potential and Field Potential in Human iPS Cell-Derived Cardiomyocytes

Tomohiko Taniguchi, Kohei Sawada

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 88 189-189 2017年11月
Trial for Drug-Induced Epileptogenic Phenotype Classification in Primary Rodent Neurons and Human Induced Pluripotent Stem Cell-Derived Neuron

Norimasa Miyamoto, Tadashi Kadowaki, Kohei Sawada

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 88 188-188 2017年11月
Drug-Induced Torsadogenic Risk Prediction Using Human iPS Cell-Derived Cardiomyocytes and MEA System (I)

Hiroyuki Ando, Takashi Yoshinaga, Wataru Yamamoto, Keiichi Asakura, Tomohiko Taniguchi, Atsuko Ojima, Takaaki Uda, Raku Shinkyo, Kiyomi Kikuchi, Tomoharu Osada …

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 88 186-186 2017年11月
Humoral factor from rodent astrocytes promoted the synaptic transmission and augmented synchronized population bursts in human induced pluripotent stem cell-derived neurons

Norimasa Miyamoto, Kohei Sawada

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 81 386-386 2016年9月
The unbound concentration of multimodal drugs in the assay medium used in the multi-electrode array system for cardiac risk assessment with iPS cell-derived cardiomyocytes

Takashi Yoshinaga, Raku Shinkyo, Kiyomi Kikuchi, Tomohiko Taniguchi, Yuko Sekino, Kohei Sawada

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 81 388-389 2016年9月
Cardiac safety assessment of drugs using three-dimensional heart simulator

Jun-ichi Okada, Takashi Yoshinaga, Junko Kurokawa, Takumi Washio, Tetsushi Furukawa, Kohei Sawada, Seiryo Sugiura, Toshiaki Hisada

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 81 351-351 2016年9月
Challenges in detection of premonitory electroencephalographic (EEG) changes of drug-induced seizure using a non-human primate EEG telemetry model

Motohiro Shiotani, Norihiro Nagano, Akiyoshi Ishikawa, Keita Sakai, Takashi Yoshinaga, Hiroshi Kato, Tetsuyuki Teramoto, Yoshiaki Furuya, Kohei Sawada

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 81 337-337 2016年9月
Cardiac toxicity Prediction of drug using Three-dimensional Heart Simulator

Jun-ichi Okada, Takashi Yoshinaga, Junko Kurokawa, Takumi Washio, Tetsushi Furukawa, Kohei Sawada, Seiryo Sugiura, Toshiaki Hisada

JOURNAL OF PHARMACOLOGICAL SCIENCES 130(3) S61-S61 2016年3月
Multi-scale heart simulator, UT-heart is useful for proarrhythmia prediction based on cardiac multi-ion channel data

Takashi Yoshinaga, Junichi Okada, Junko Kurokawa, Tomohiko Taniguchi, Tetsuya Furukawa, Seiryo Sugiura, Toshiaki Hisada, Kohei Sawada

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 75 172-172 2015年9月
心臓シミュレータを用いた薬剤の催不整脈リスク評価

岡田純一, 吉永貴志, 黒川洵子, 鷲尾巧, 深瀬広幸, 杉山篤, 古川哲史, 澤田光平, 杉浦清了, 久田俊明

日本毒性学会学術年会 42 S14-4 2015年
Force-frequency analysis of contraction using a novel laser-speckle contrast techniques in iPS-derived cardiomyocytes, Repro Cardio2 (TM)

Kohei Sawada, Atsuko Ojima, Tomohiko Taniguchi, Norimasa Miyamoto, Hidenao Iwai, Norikazu Sugiyama, Takuji Kataoka, Shunsuke Yoshida

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 70(3) 355-356 2014年11月
Optimization and pharmacological characterization of iCell cardiomyocytes for electrophysiological assessment in a multi-electrode extracellular recording system

Kohei Sawada, Tomohiko Taniguchi, Atsuko Ojima, Takkashi Yoshinaga, Norimasa Miyamoto

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 70(3) 356-356 2014年11月
Integrated risk assessment of hNav1.5 liabilities for cardiac function

Takashi Yoshinaga, Hiroshi Kato, Hiroshi Mizuno, Kohei Sawada

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 70(3) 328-328 2014年11月
Establishment of small molecule-based in silico models for prediction of hERG and Nav1.5 inhibitions for drug discovery

Megumi Ikemori Kawada, Tetsushi Dodo, Melvin Yu, Takashi Yoshinaga, Atsushi Inoue, Kohei Sawada

TOXICOLOGY LETTERS 229 S161-S161 2014年9月
Basic approach to optimize the small drug seeds with minimized CV risks on the early stage of drug discovery by using small molecule-based in silico models for prediction of hERG/Nav1.5 inhibitions

Tetsushi Dodo, Megumi Ikemori Kawada, Melvin Yu, Takashi Yoshinaga, Atsushi Inoue, Kohei Sawada

TOXICOLOGY LETTERS 229 S159-S159 2014年9月
Assessment of Testing Methods for Evaluating Drug-Induced Repolarization Delay with iPS-Derived Cardiomyocyte Sheet: Multisite Validation Study

Yuji Nakamura, Junko Matsuo, Norimasa Miyamoto, Atsuko Ojima, Kentaro Ando, Yasunari Kanda, Kohei Sawada, Atsushi Sugiayama, Yuko Sekino

JOURNAL OF PHARMACOLOGICAL SCIENCES 124 107P-107P 2014年
Analysis of mechanism of chronic probucol effects on the slow component of the delayed-rectifier potassium current in CHO cells transfected with KCNQ1 and KCNE1

Tomohiko Taniguchi, Taro Hihara, Norimasa Miyamoto, Mai Uesugi, Takashi Yoshinaga, Kohei Sawada

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 68(1) E6-E7 2013年7月
A novel method of selecting human embryonic stem cell-derived cardiomyocyte clusters for reliable QT risk assessment

Taro Hihara, Kazuto Yamazaki, Tomohiko Taniguchi, Naohiro Kohmura, Takashi Yoshinaga, Masashi Ito, Kohei Sawada

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 66(2) 166-166 2012年9月

もっとみる

澤田光平

基本情報

研究キーワード

研究分野

経歴

委員歴

論文

MISC

メニュー

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