SHIEN KAZUHIKO

Last updated: Jul 20, 2019 at 15:13

Name	SHIEN KAZUHIKO
Affiliation	Okayama University

Research Interests

Thoracic Surgery(112) , Lung Cancer(171) , Mesothelioma(11)

Research Areas

Genome science / Medical genome science /
Oncology / Tumor biology /
Clinical surgery / Respiratory surgery /

Published Papers

Plain Text

Newly developed anti-S100A8/A9 monoclonal antibody efficiently prevents lung tropic cancer metastasis.

Kinoshita R, Sato H, Yamauchi A, Takahashi Y, Inoue Y, Sumardika IW, Chen Y, Tomonobu N, Araki K, Shien K, Tomida S, Torigoe H, Namba K, Kurihara E, Ogoshi Y, Murata H, Yamamoto KI, Futami J, Putranto EW, Ruma IMW, Yamamoto H, Soh J, Hibino T, Nishibori M, Kondo E, Toyooka S, Sakaguchi M

International journal of cancer 145(2) 569-575 Nov 2018 [Refereed]

Clinical outcome of patients with recurrent non-small cell lung cancer after trimodality therapy.

Suzawa K, Soh J, Takahashi Y, Sato H, Shien K, Yamamoto H, Kanazawa S, Kiura K, Miyoshi S, Toyooka S

Surgery today 49(7) 601-609 Jul 2019 [Refereed]

Comparative mutational evaluation of multiple lung cancers by multiplex oncogene mutation analysis.

Takahashi Y, Shien K, Tomida S, Oda S, Matsubara T, Sato H, Suzawa K, Kurihara E, Ogoshi Y, Namba K, Yoshioka T, Torigoe H, Yamamoto H, Soh J, Toyooka S

Cancer science 109(11) 3634-3642 Nov 2018 [Refereed]

Critical role of the MCAM-ETV4 axis triggered by extracellular S100A8/A9 in breast cancer aggressiveness.

Chen Y, Sumardika IW, Tomonobu N, Kinoshita R, Inoue Y, Iioka H, Mitsui Y, Saito K, Ruma IMW, Sato H, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Futami J, Kubo M, Putranto EW, Murakami T, Liu M, Hibino T, Nishibori M, Kondo E, Toyooka S, Sakaguchi M

Neoplasia (New York, N.Y.) 21(7) 627-640 Jul 2019 [Refereed]

exSSSRs (extracellular S100 Soil Sensor Receptors)-Fc fusion proteins work as prominent decoys to S100A8/A9-induced lung tropic cancer metastasis.

Kinoshita R, Sato H, Yamauchi A, Takahashi Y, Inoue Y, Sumardika IW, Chen Y, Tomonobu N, Araki K, Shien K, Tomida S, Torigoe H, Namba K, Kurihara E, Ogoshi Y, Murata H, Yamamoto KI, Futami J, Putranto EW, Winarsa Ruma IM, Yamamoto H, Soh J, Hibino T, Nishibori M, Kondo E, Toyooka S, Sakaguchi M

International journal of cancer 144(12) 3138-3145 Oct 2018 [Refereed]

Neuroplastin-β mediates S100A8/A9-induced lung cancer disseminative progression.

Sumardika IW, Chen Y, Tomonobu N, Kinoshita R, Ruma IMW, Sato H, Kondo E, Inoue Y, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Futami J, Putranto EW, Hibino T, Nishibori M, Toyooka S, Sakaguchi M

Molecular carcinogenesis 58(6) 980-995 Jun 2019 [Refereed]

Combined inhibition of MEK and PI3K pathways overcomes acquired resistance to EGFR-TKIs in non-small cell lung cancer.

Sato H, Yamamoto H, Sakaguchi M, Shien K, Tomida S, Shien T, Ikeda H, Hatono M, Torigoe H, Namba K, Yoshioka T, Kurihara E, Ogoshi Y, Takahashi Y, Soh J, Toyooka S

Cancer science 109(10) 3183-3196 Oct 2018 [Refereed]

Melanoma cell adhesion molecule is the driving force behind the dissemination of melanoma upon S100A8/A9 binding in the original skin lesion.

Chen Y, Sumardika IW, Tomonobu N, Winarsa Ruma IM, Kinoshita R, Kondo E, Inoue Y, Sato H, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Liu M, Futami J, Sasai K, Katayama H, Kubo M, Putranto EW, Hibino T, Sun B, Nishibori M, Toyooka S, Sakaguchi M

Cancer letters 452 178-190 Jun 2019 [Refereed]

Concomitant targeting of the mTOR/MAPK pathways: novel therapeutic strategy in subsets of RICTOR/KRAS-altered non-small cell lung cancer.

Ruder D, Papadimitrakopoulou V, Shien K, Behrens C, Kalhor N, Chen H, Shen L, Lee JJ, Hong WK, Tang X, Girard L, Minna JD, Diao L, Wang J, Mino B, Villalobos P, Rodriguez-Canales J, Hanson NE, Sun J, Miller V, Greenbowe J, Frampton G, Herbst RS, Baladandayuthapani V, Wistuba II, Izzo JG

Oncotarget 9(74) 33995-34008 Sep 2018 [Refereed]

Droplet digital PCR as a novel system for the detection of microRNA‑34b/c methylation in circulating DNA in malignant pleural mesothelioma.

Sato H, Soh J, Aoe K, Fujimoto N, Tanaka S, Namba K, Torigoe H, Shien K, Yamamoto H, Tomida S, Tao H, Okabe K, Kishimoto T, Toyooka S

International journal of oncology 54(6) 2139-2148 Jun 2019 [Refereed]

Myoepithelioma occurring in the posterior mediastinum harboring EWSR1 rearrangement: a case report.

Habu T, Soh J, Toji T, Shien K, Niman E, Namba K, Sato H, Yamamoto H, Sugimoto S, Yamane M, Toyooka S

Japanese journal of clinical oncology 48(9) 851-854 Sep 2018 [Refereed]

Acquired resistance mechanisms to afatinib in HER2-amplified gastric cancer cells.

Yoshioka T, Shien K, Takeda T, Takahashi Y, Kurihara E, Ogoshi Y, Namba K, Torigoe H, Sato H, Tomida S, Yamamoto H, Soh J, Fujiwara T, Toyooka S

Cancer science Jun 2019 [Refereed]

[Induction Chemoradiotherapy for Locally Advanced Non-small Cell Lung Cancer].

Miura A, Soh J, Shien K, Yamamoto H, Toyooka S

Kyobu geka. The Japanese journal of thoracic surgery 71(4) 270-277 Apr 2018 [Refereed]

Ganetespib in Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor-resistant Non-small Cell Lung Cancer.

Kurihara E, Shien K, Torigoe H, Takeda T, Takahashi Y, Ogoshi Y, Yoshioka T, Namba K, Sato H, Suzawa K, Yamamoto H, Soh J, Okazaki M, Shien T, Tomida S, Toyooka S

Anticancer research 39(4) 1767-1775 Apr 2019 [Refereed]

Tumor-suppressive effect of LRIG1, a negative regulator of ErbB, in non-small cell lung cancer harboring mutant EGFR.

Torigoe H, Yamamoto H, Sakaguchi M, Youyi C, Namba K, Sato H, Shien K, Soh J, Suzawa K, Tomida S, Tsukuda K, Miyoshi S, Toyooka S

Carcinogenesis 39(5) 719-727 Mar 2018 [Refereed]

Anti-tumor effect of neratinib against lung cancer cells harboring HER2 oncogene alterations.

Ogoshi Y, Shien K, Yoshioka T, Torigoe H, Sato H, Sakaguchi M, Tomida S, Namba K, Kurihara E, Takahashi Y, Suzawa K, Yamamoto H, Soh J, Toyooka S

Oncology letters 17(3) 2729-2736 Mar 2019 [Refereed]

Therapeutic strategies for afatinib-resistant lung cancer harboring HER2 alterations.

Torigoe H, Shien K, Takeda T, Yoshioka T, Namba K, Sato H, Suzawa K, Yamamoto H, Soh J, Sakaguchi M, Tomida S, Tsukuda K, Miyoshi S, Toyooka S

Cancer science 109(5) 1493-1502 Mar 2018 [Refereed]

Pulmonary resection in a prone position for lung cancer invading the spine.

Miyauchi S, Soh J, Shien K, Tanaka M, Yamamoto H, Ozaki T, Toyooka S

General thoracic and cardiovascular surgery Mar 2019 [Refereed]

Activation of AXL as a Preclinical Acquired Resistance Mechanism Against Osimertinib Treatment in EGFR-Mutant Non-Small Cell Lung Cancer Cells.

Namba K, Shien K, Takahashi Y, Torigoe H, Sato H, Yoshioka T, Takeda T, Kurihara E, Ogoshi Y, Yamamoto H, Soh J, Tomida S, Toyooka S

Molecular cancer research : MCR 17(2) 499-507 Feb 2019 [Refereed]

β-1,3-Galactosyl-O-Glycosyl-Glycoprotein β-1,6-N-Acetylglucosaminyltransferase 3 Increases MCAM Stability, Which Enhances S100A8/A9-Mediated Cancer Motility.

Sumardika IW, Youyi C, Kondo E, Inoue Y, Ruma IMW, Murata H, Kinoshita R, Yamamoto KI, Tomida S, Shien K, Sato H, Yamauchi A, Futami J, Putranto EW, Hibino T, Toyooka S, Nishibori M, Sakaguchi M

Oncology research 26(3) 431-444 Apr 2018 [Refereed]

Antitumor activity of pan-HER inhibitors in HER2-positive gastric cancer.

Yoshioka T, Shien K, Namba K, Torigoe H, Sato H, Tomida S, Yamamoto H, Asano H, Soh J, Tsukuda K, Nagasaka T, Fujiwara T, Toyooka S

Cancer science 109(4) 1166-1176 Feb 2018 [Refereed]

Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naïve lung adenocarcinoma.

Namba K, Tomida S, Matsubara T, Takahashi Y, Kurihara E, Ogoshi Y, Yoshioka T, Takeda T, Torigoe H, Sato H, Shien K, Yamamoto H, Soh J, Tsukuda K, Toyooka S

BMC cancer 19(1) 175 Feb 2019 [Refereed]

Therapeutic potential of targeting S100A11 in malignant pleural mesothelioma.

Sato H, Sakaguchi M, Yamamoto H, Tomida S, Aoe K, Shien K, Yoshioka T, Namba K, Torigoe H, Soh J, Tsukuda K, Tao H, Okabe K, Miyoshi S, Pass HI, Toyooka S

Oncogenesis 7(1) 11 Jan 2018 [Refereed]

Advantage of Induction Chemoradiotherapy for Lung Cancer in Securing Cancer-Free Bronchial Margin.

Sato H, Toyooka S, Soh J, Hotta K, Katsui K, Shien K, Yamamoto H, Oto T, Kanazawa S, Kiura K, Miyoshi S

The Annals of thoracic surgery 104(3) 971-978 Sep 2017 [Refereed]

JAK1/STAT3 Activation through a Proinflammatory Cytokine Pathway Leads to Resistance to Molecularly Targeted Therapy in Non-Small Cell Lung Cancer.

Shien K, Papadimitrakopoulou VA, Ruder D, Behrens C, Shen L, Kalhor N, Song J, Lee JJ, Wang J, Tang X, Herbst RS, Toyooka S, Girard L, Minna JD, Kurie JM, Wistuba II, Izzo JG

Molecular cancer therapeutics 16(10) 2234-2245 Oct 2017 [Refereed]

Elacridar, a third-generation ABCB1 inhibitor, overcomes resistance to docetaxel in non-small cell lung cancer.

Chen H, Shien K, Suzawa K, Tsukuda K, Tomida S, Sato H, Torigoe H, Watanabe M, Namba K, Yamamoto H, Soh J, Asano H, Miyoshi S, Toyooka S

Oncology letters 14(4) 4349-4354 Oct 2017 [Refereed]

Distant Bystander Effect of REIC/DKK3 Gene Therapy Through Immune System Stimulation in Thoracic Malignancies.

Suzawa K, Shien K, Peng H, Sakaguchi M, Watanabe M, Hashida S, Maki Y, Yamamoto H, Tomida S, Soh J, Asano H, Tsukuda K, Nasu Y, Kumon H, Miyoshi S, Toyooka S

Anticancer research 37(1) 301-307 Jan 2017 [Refereed]

Is tumor location an independent prognostic factor in locally advanced non-small cell lung cancer treated with trimodality therapy?

Shien K, Toyooka S, Soh J, Yamamoto H, Miyoshi S

Journal of thoracic disease 9(5) E489-E491 May 2017 [Refereed]

Targeting the miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features.

Sato H, Shien K, Tomida S, Okayasu K, Suzawa K, Hashida S, Torigoe H, Watanabe M, Yamamoto H, Soh J, Asano H, Tsukuda K, Miyoshi S, Toyooka S

Scientific reports 7 40847 Jan 2017 [Refereed]

Induction chemoradiotherapy using docetaxel and cisplatin with definitive-dose radiation followed by surgery for locally advanced non-small cell lung cancer.

Torigoe H, Soh J, Tomida S, Namba K, Sato H, Katsui K, Hotta K, Shien K, Yamamoto H, Yamane M, Kanazawa S, Kiura K, Miyoshi S, Toyooka S

Journal of thoracic disease 9(9) 3076-3086 Sep 2017 [Refereed]

Interaction of cytokeratin 19 head domain and HER2 in the cytoplasm leads to activation of HER2-Erk pathway.

Ohtsuka T, Sakaguchi M, Yamamoto H, Tomida S, Takata K, Shien K, Hashida S, Miyata-Takata T, Watanabe M, Suzawa K, Soh J, Youyi C, Sato H, Namba K, Torigoe H, Tsukuda K, Yoshino T, Miyoshi S, Toyooka S

Scientific reports 6 39557 Dec 2016 [Refereed]

Yes1 signaling mediates the resistance to Trastuzumab/Lap atinib in breast cancer.

Takeda T, Yamamoto H, Kanzaki H, Suzawa K, Yoshioka T, Tomida S, Cui X, Murali R, Namba K, Sato H, Torigoe H, Watanabe M, Shien K, Soh J, Asano H, Tsukuda K, Kitamura Y, Miyoshi S, Sendo T, Toyooka S

PloS one 12(2) e0171356 2017 [Refereed]

Role of surgery in N2 NSCLC: pros.

Shien K, Toyooka S, Japanese journal of clinical oncology

Japanese journal of clinical oncology 46(12) 1168-1173 Sep 2016 [Refereed]

Shien K, Toyooka S, Japanese journal of clinical oncology, 2016, 2016

Predictive biomarkers of response to PD-1/PD-L1 immune checkpoint inhibitors in non-small cell lung cancer.

Shien K, Papadimitrakopoulou VA, Wistuba II, Lung cancer, Amsterdam, Netherlands), vol. 99, pp. 79-87

Lung cancer (Amsterdam, Netherlands) 99 79-87 Sep 2016 [Refereed]

Shien K, Papadimitrakopoulou VA, Wistuba II, Lung cancer (Amsterdam, Netherlands), 2016, vol. 99, pp. 79-87, 2016

The proliferative effects of asbestos-exposed peripheral blood mononuclear cells on mesothelial cells.

Maki Y, Nishimura Y, Toyooka S, Soh J, Tsukuda K, Shien K, Furukawa M, Muraoka T, Ueno T, Tanaka N, Yamamoto H, Asano H, Maeda M, Kumagai-Takei N, Lee S, Matsuzaki H, Otsuki T, Miyoshi S, Oncology letters, vol. 11, no. 5, pp. 3308-3316

Oncology letters 11(5) 3308-3316 May 2016 [Refereed]

Study about the Efficacy of Metformin to Immune Function in Cancer Patients.

Watanabe M, Yamamoto H, Eikawa S, Shien K, Shien T, Soh J, Hotta K, Wada J, Hinotsu S, Fujiwara T, Kiura K, Doihara H, Miyoshi S, Udono H, Toyooka S, Acta medica Okayama, vol. 70, no. 4, pp. 327-330

Acta medica Okayama 70(4) 327-330 Aug 2016 [Refereed]

Watanabe M, Yamamoto H, Eikawa S, Shien K, Shien T, Soh J, Hotta K, Wada J, Hinotsu S, Fujiwara T, Kiura K, Doihara H, Miyoshi S, Udono H, Toyooka S, Acta medica Okayama, 2016, vol. 70, no. 4, pp. 327-330, 2016

Genetic alterations in lung adenocarcinoma with a micropapillary component.

Furukawa M, Toyooka S, Ichimura K, Yamamoto H, Soh J, Hashida S, Ouchida M, Shien K, Asano H, Tsukuda K, Miyoshi S, Molecular, clinical oncology, vol. 4, no. 2, pp. 195-200

Molecular and clinical oncology 4(2) 195-200 Feb 2016 [Refereed]

Furukawa M, Toyooka S, Ichimura K, Yamamoto H, Soh J, Hashida S, Ouchida M, Shien K, Asano H, Tsukuda K, Miyoshi S, Molecular and clinical oncology, 2016, vol. 4, no. 2, pp. 195-200, 2016

Establishment and molecular characterization of cell lines from Japanese patients with malignant pleural mesothelioma.

Suzawa K, Yamamoto H, Murakami T, Katayama H, Furukawa M, Shien K, Hashida S, Okabe K, Aoe K, Soh J, Asano H, Tsukuda K, Mimura Y, Toyooka S, Miyoshi S, Oncology letters, vol. 11, no. 1, pp. 705-712

Oncology letters 11(1) 705-712 Jan 2016 [Refereed]

Suzawa K, Yamamoto H, Murakami T, Katayama H, Furukawa M, Shien K, Hashida S, Okabe K, Aoe K, Soh J, Asano H, Tsukuda K, Mimura Y, Toyooka S, Miyoshi S, Oncology letters, 2016, vol. 11, no. 1, pp. 705-712, 2016

DNA copy number gains in malignant pleural mesothelioma.

Furukawa M, Toyooka S, Hayashi T, Yamamoto H, Fujimoto N, Soh J, Hashida S, Shien K, Asano H, Aoe K, Okabe K, Pass HI, Tsukuda K, Kishimoto T, Miyoshi S, Oncology letters, vol. 10, no. 5, pp. 3274-3278

Oncology letters 10(5) 3274-3278 Nov 2015 [Refereed]

Furukawa M, Toyooka S, Hayashi T, Yamamoto H, Fujimoto N, Soh J, Hashida S, Shien K, Asano H, Aoe K, Okabe K, Pass HI, Tsukuda K, Kishimoto T, Miyoshi S, Oncology letters, 2015, vol. 10, no. 5, pp. 3274-3278, 2015

ß-1,3-galactosyl-O-glycosyl-glycoprotein ß-1,6-N-acetylglucosaminyltransferase 3 Increases MCAM Stability, Which Enhances S100A8/A9-Mediated Cancer Motility.

Oncology research Sep 2017 [Refereed]

Acquisition of cancer stem cell-like properties in non-small cell lung cancer with acquired resistance to afatinib

Hashida S, Yamamoto H, Shien K, Miyoshi Y, Ohtsuka T, Suzawa K, Watanabe M, Maki Y, Soh J, Asano H, Tsukuda K, Miyoshi S, Toyooka S.

Cancer Sci 106(10) 1377-84 Oct 2015 [Refereed]

Clinicopathological characteristics and lymph node metastasis pathway of non-small-cell lung cancer located in the left lingular division

Shien K, Toyooka S, Soh J, Okami J, Higashiyama M, Kadota Y, Maeda H, Hayama M, Chida M, Funaki S, Okumura M, Miyoshi S.

Interact Cardiovasc Thorac Surg 20(6) 791-6 Jun 2015 [Refereed]

Extended sleeve lobectomy after induction chemoradiotherapy for non-small cell lung cancer

Toyooka S, Soh J, Yamamoto H, Yamane M, Hattori S, Shien K, Miyoshi K, Sugimoto S, Oto T, Miyoshi S.

Surg Today 45(9) 1121-6 Sep 2015 [Refereed]

Hsp90 inhibitor NVP-AUY922 enhances the radiation sensitivity of lung cancer cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors

Hashida S, Yamamoto H, Shien K, Ohtsuka T, Suzawa K, Maki Y, Furukawa M, Soh J, Asano H, Tsukuda K, Miyoshi S, Kanazawa S, Toyooka S.

Oncol Rep 33(3) 1499-504 Mar 2015 [Refereed]

Lower lobe origin is a poor prognostic factor in locally advanced non-small-cell lung cancer patients treated with induction chemoradiotherapy

Shien K, Toyooka S, Soh J, Hotta K, Katsui K, Oto T, Kanazawa S, Kiura K, Date H, Miyoshi S.

Mol Clin Oncol 3(3) 706-712 May 2015 [Refereed]

Preclinical evaluation of microRNA-34b/c delivery for malignant pleural mesothelioma.

Ueno T, Toyooka S, Fukazawa T, Kubo T, Soh J, Asano H, Muraoka T, Tanaka N, Maki Y, Shien K, Furukawa M, Sakaguchi M, Yamamoto H, Tsukuda K, Miyoshi S

Acta medica Okayama 68(1) 23-26 Feb 2014 [Refereed]

Density of Tumor-Infiltrating FOXP3+ T Cells as a Response Marker for Induction Chemoradiotherapy and a Potential Prognostic Factor in Patients Treated with Trimodality Therapy for Locally Advanced Non-Small Cell Lung Cancer.

Tao H, Shien K, Soh J, Matsuda E, Toyooka S, Okabe K, Miyoshi S

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 20(6) 980-6 Feb 2014 [Refereed]

Novel germline mutation in the transmembrane domain of HER2 in familial lung adenocarcinomas.

Yamamoto H, Higasa K, Sakaguchi M, Shien K, Soh J, Ichimura K, Furukawa M, Hashida S, Tsukuda K, Takigawa N, Matsuo K, Kiura K, Miyoshi S, Matsuda F, Toyooka S

Journal of the National Cancer Institute 106(1) djt338 Jan 2014 [Refereed]

Anti-cancer effects of REIC/Dkk-3-encoding adenoviral vector for the treatment of non-small cell lung cancer.

Shien K, Tanaka N, Watanabe M, Soh J, Sakaguchi M, Matsuo K, Yamamoto H, Furukawa M, Asano H, Tsukuda K, Nasu Y, Huh NH, Miyoshi S, Kumon H, Toyooka S

PloS one 9(2) e87900 2014 [Refereed]

Drug resistance to EGFR tyrosine kinase inhibitors for non-small cell lung cancer

Shien K, Yamamoto H, Soh J, Miyoshi S, Toyooka S.

Acta Med Okayama 68(4) 191-200 2014 [Refereed]

Presence of the minor EGFR T790M mutation is associated with drug-sensitive EGFR mutations in lung adenocarcinoma patients

Hashida S, Soh J, Toyooka S, Tanaka T, Furukawa M, Shien K, Yamamoto H, Asano H, Tsukuda K, Hagiwara K, Miyoshi S.

Oncol Rep 32(1) 145-52 Jul 2014 [Refereed]

The degree of microRNA-34b/c methylation in serum-circulating DNA is associated with malignant pleural mesothelioma.

Muraoka T, Soh J, Toyooka S, Aoe K, Fujimoto N, Hashida S, Maki Y, Tanaka N, Shien K, Furukawa M, Yamamoto H, Asano H, Tsukuda K, Kishimoto T, Otsuki T, Miyoshi S

Lung cancer (Amsterdam, Netherlands) 82(3) 485-490 Dec 2013 [Refereed]

Validity of using lobe-specific regional lymph node stations to assist navigation during lymph node dissection in early stage non-small cell lung cancer patients.

Miyoshi S, Shien K, Toyooka S, Miyoshi K, Yamamoto H, Sugimoto S, Soh J, Hayama M, Yamane M, Oto T

Surgery today 44(11) 2028-36 Oct 2013 [Refereed]

Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells.

Shien K, Toyooka S, Yamamoto H, Soh J, Jida M, Thu KL, Hashida S, Maki Y, Ichihara E, Asano H, Tsukuda K, Takigawa N, Kiura K, Gazdar AF, Lam WL, Miyoshi S

Cancer research 73(10) 3051-61 Mar 2013 [Refereed]

Downregulation of microRNA-34 induces cell proliferation and invasion of human mesothelial cells.

Tanaka N, Toyooka S, Soh J, Tsukuda K, Shien K, Furukawa M, Muraoka T, Maki Y, Ueno T, Yamamoto H, Asano H, Otsuki T, Miyoshi S

Oncology reports 29(6) 2169-2174 Mar 2013 [Refereed]

Use of a vessel sealing system versus conventional electrocautery for lung parenchymal resection: a comparison of the clinicopathological outcomes in porcine lungs.

Sugimoto S, Toyooka S, Iga N, Furukawa M, Sugimoto R, Shien K, Nishikawa H, Soh J, Yamane M, Oto T, Miyoshi S

Surgery today 44(3) 540-545 Mar 2013 [Refereed]

Sacrificing the pulmonary arterial branch to the spared lobe is a risk factor of bronchopleural fistula in sleeve lobectomy after chemoradiotherapy.

Toyooka S, Soh J, Shien K, Sugimoto S, Yamane M, Oto T, Date H, Miyoshi S

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 43(3) 568-572 Mar 2013 [Refereed]

Impact of GLUT1 and Ki-67 expression on early‑stage lung adenocarcinoma diagnosed according to a new international multidisciplinary classification.

Maki Y, Soh J, Ichimura K, Shien K, Furukawa M, Muraoka T, Tanaka N, Ueno T, Yamamoto H, Asano H, Tsukuda K, Toyooka S, Miyoshi S

Oncology reports 29(1) 133-140 Jan 2013 [Refereed]

Impact of aberrant methylation of microRNA-9 family members on non-small cell lung cancers

Muraoka T, Soh J, Toyooka S, Maki Y, Shien K, Furukawa M, Ueno T, Tanaka N, Yamamoto H, Asano H, Tsukuda K, Miyoshi S.

Mol Clin Oncol 1(1) 185-189 Jan 2013 [Refereed]

Silenced expression of NFKBIA in lung adenocarcinoma patients with a never-smoking history.

Furukawa M, Soh J, Yamamoto H, Ichimura K, Shien K, Maki Y, Muraoka T, Tanaka N, Ueno T, Asano H, Tsukuda K, Toyooka S, Miyoshi S

Acta medica Okayama 67(1) 19-24 2013 [Refereed]

Induction chemoradiotherapy is superior to induction chemotherapy for the survival of non-small-cell lung cancer patients with pathological mediastinal lymph node metastasis.

Toyooka S, Kiura K, Shien K, Katsui K, Hotta K, Kanazawa S, Date H, Miyoshi S

Interactive cardiovascular and thoracic surgery 15(6) 954-960 Dec 2012 [Refereed]

MicroRNA miR-34b/c enhances cellular radiosensitivity of malignant pleural mesothelioma cells.

Maki Y, Asano H, Toyooka S, Soh J, Kubo T, Katsui K, Ueno T, Shien K, Muraoka T, Tanaka N, Yamamoto H, Tsukuda K, Kishimoto T, Kanazawa S, Miyoshi S

Anticancer research 32(11) 4871-4875 Nov 2012 [Refereed]

Knockdown of the epidermal growth factor receptor gene to investigate its therapeutic potential for the treatment of non-small-cell lung cancers.

Shien K, Ueno T, Tsukuda K, Soh J, Suda K, Kubo T, Furukawa M, Muraoka T, Maki Y, Tanaka N, Yamamoto H, Kiura K, Mitsudomi T, Toyooka S, Miyoshi S

Clinical lung cancer 13(6) 488-493 Nov 2012 [Refereed]

Induction chemoradiotherapy followed by surgical resection for clinical T3 or T4 locally advanced non-small cell lung cancer.

Shien K, Toyooka S, Kiura K, Matsuo K, Soh J, Yamane M, Oto T, Takemoto M, Date H, Miyoshi S

Annals of surgical oncology 19(8) 2685-2692 Aug 2012 [Refereed]

Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.

Ohashi K, Sequist LV, Arcila ME, Moran T, Chmielecki J, Lin YL, Pan Y, Wang L, de Stanchina E, Shien K, Aoe K, Toyooka S, Kiura K, Fernandez-Cuesta L, Fidias P, Yang JC, Miller VA, Riely GJ, Kris MG, Engelman JA, Vnencak-Jones CL, Dias-Santagata D, Ladanyi M, Pao W

Proceedings of the National Academy of Sciences of the United States of America 109(31) E2127-33 Jul 2012 [Refereed]

Prognostic impact of cancer stem cell-related markers in non-small cell lung cancer patients treated with induction chemoradiotherapy.

Shien K, Toyooka S, Ichimura K, Soh J, Furukawa M, Maki Y, Muraoka T, Tanaka N, Ueno T, Asano H, Tsukuda K, Yamane M, Oto T, Kiura K, Miyoshi S

Lung cancer (Amsterdam, Netherlands) 77(1) 162-167 Jul 2012 [Refereed]

Frequent methylation and oncogenic role of microRNA-34b/c in small-cell lung cancer.

Tanaka N, Toyooka S, Soh J, Kubo T, Yamamoto H, Maki Y, Muraoka T, Shien K, Furukawa M, Ueno T, Asano H, Tsukuda K, Aoe K, Miyoshi S

Lung cancer (Amsterdam, Netherlands) 76(1) 32-38 Apr 2012 [Refereed]

Strong anti-tumor effect of NVP-AUY922, a novel Hsp90 inhibitor, on non-small cell lung cancer.

Ueno T, Tsukuda K, Toyooka S, Ando M, Takaoka M, Soh J, Asano H, Maki Y, Muraoka T, Tanaka N, Shien K, Furukawa M, Yamatsuji T, Kiura K, Naomoto Y, Miyoshi S

Lung cancer (Amsterdam, Netherlands) 76(1) 26-31 Apr 2012 [Refereed]

Ectopic cervical thymoma: a case report with 18F-fluorodeoxyglucose positron emission tomography findings.

Shien K, Shien T, Soh J, Ikeda H, Nogami T, Taira N, Doihara H, Miyoshi S

Acta medica Okayama 66(4) 357-361 2012 [Refereed]

Combination treatment with fulvestrant and various cytotoxic agents (doxorubicin, paclitaxel, docetaxel, vinorelbine, and 5-fluorouracil) has a synergistic effect in estrogen receptor-positive breast cancer.

Ikeda H, Taira N, Nogami T, Shien K, Okada M, Shien T, Doihara H, Miyoshi S

Cancer science 102(11) 2038-2042 Nov 2011 [Refereed]

Primary lung cancer surgery after curative chemoradiotherapy for esophageal cancer patients.

Shien K, Yamashita M, Okazaki M, Suehisa H, Sawada S, Miyoshi S

Interactive cardiovascular and thoracic surgery 12(6) 1002-1006 Jun 2011 [Refereed]

Pulmonary mucosa-associated lymphoid tissue lymphoma with a pulmonary arteriovenous fistula.

Shien K, Yamashita M, Okazaki M, Suehisa H, Sawada S, Kurita A

General thoracic and cardiovascular surgery 59(5) 371-375 May 2011 [Refereed]

Association Memberships

THE JAPAN SOCIETY OF HUMAN GENETICS(391) , JAPAN SURGICAL ASSOCIATION(221) , JAPAN SURGICAL SOCIETY(594) , THE JAPANESE ASSOCIATION FOR THORACIC SURGERY(154) , THE JAPANESE ASSOCIATION FOR CHEST SURGERY(78) , THE JAPAN LUNG CANCER SOCIETY(217) , JAPAN SOCIETY OF CLINICAL ONCOLOGY(534)