2017年1月
Distant Bystander Effect of REIC/DKK3 Gene Therapy Through Immune System Stimulation in Thoracic Malignancies.
Anticancer research
- 巻
- 37
- 号
- 1
- 開始ページ
- 301
- 終了ページ
- 307
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.21873/anticanres.11321
- 出版者・発行元
- INT INST ANTICANCER RESEARCH
BACKGROUND: Reduced expression in immortalized cell (REIC)/Dickkoph-3 (DKK3) is a tumor-suppressor gene, and its overexpression by adenovirus vector (Ad-REIC) exhibits a remarkable therapeutic effect on various human cancer types through a mechanism triggered by endoplasmic reticulum stress. MATERIALS AND METHODS: We examined the direct anti-tumor effect of Ad-REIC gene therapy on lung cancer and malignant mesothelioma cell lines in vitro, and the distant bystander effect using immunocompetent mouse allograft models with bilateral flank tumors. RESULTS: Ad-REIC treatment showed antitumor effect in many lung cancer and malignant mesothelioma cell lines in vitro. In an in vivo model, Ad-REIC treatment inhibited the growth not only of directly treated tumors but also of distant untreated tumors. By immunohistochemical analysis, infiltration of T-cells and natural killer (NK) cells and expression of the major histocompatibility complex (MHC) class I molecules were observed in bilateral tumors. CONCLUSION: Ad-REIC treatment not only had a direct antitumor effect but also an indirect bystander effect through stimulation of the immune system.
- リンク情報
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- DOI
- https://doi.org/10.21873/anticanres.11321
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/28011506
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000391958800040&DestApp=WOS_CPL
- URL
- http://europepmc.org/abstract/med/28011506
- ID情報
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- DOI : 10.21873/anticanres.11321
- ISSN : 0250-7005
- eISSN : 1791-7530
- ORCIDのPut Code : 38241025
- PubMed ID : 28011506
- Web of Science ID : WOS:000391958800040