嶋田和也 (Kazuya Shimada) - マイポータル

基本情報

所属: 東京慈恵会医科大学ウイルス学講座

学位: 医学博士(大阪大学)

J-GLOBAL ID: 201801000513420348
researchmap会員ID: B000305945

研究キーワード

研究分野

ライフサイエンス / ウイルス学 /

論文

Identification of a strong genetic risk factor for major depressive disorder in the human virome.

Nobuyuki Kobayashi, Kazuya Shimada, Azusa Ishii, Rui Osaka, Toshiko Nishiyama, Masahiro Shigeta, Hiroyuki Yanagisawa, Naomi Oka, Kazuhiro Kondo

iScience 27(3) 109203-109203 2024年3月15日査読有り
SARS-CoV-2 S1 protein causes brain inflammation by reducing intracerebral acetylcholine production

Naomi Oka, Kazuya Shimada, Azusa Ishii, Nobuyuki Kobayashi, Kazuhiro Kondo

iScience 26(6) 106954-106954 2023年5月査読有り
VP26, a herpes simplex virus type 1 capsid protein, increases DNA methylation in COASY promoter region.

Rui Osaka, Nobuyuki Kobayashi, Kazuya Shimada, Azusa Ishii, Naomi Oka, Kazuhiro Kondo

Brain, behavior, & immunity - health 26 100545-100545 2022年12月査読有り
SARS-CoV-2 causes brain inflammation via impaired neuro-immune interactions

Naomi Oka, Kazuya Shimada, Azusa Ishii, Nobuyuki Kobayashi, Kazuhiro Kondo

2022年7月15日
嗅球に潜伏感染したヒトヘルペスウイルス6の炎症誘導作用

岡直美, 小林伸行, 嶋田和也, 石井梓, 近藤一博

東京慈恵会医科大学雑誌 136(6) 128-129 2021年11月
Blood DNA Methylation Levels in the WNT5A Gene Promoter Region: A Potential Biomarker for Agitation in Subjects with Dementia.

Nobuyuki Kobayashi, Shunichiro Shinagawa, Tomoyuki Nagata, Kenji Tagai, Kazuya Shimada, Azusa Ishii, Naomi Oka, Masahiro Shigeta, Kazuhiro Kondo

Journal of Alzheimer's disease : JAD 81(4) 1601-1611 2021年査読有り
Increased blood COASY DNA methylation levels a potential biomarker for early pathology of Alzheimer’s disease

Nobuyuki Kobayashi, Shunichiro Shinagawa, Hidehito Niimura, Hisashi Kida, Tomoyuki Nagata, Kenji Tagai, Kazuya Shimada, Naomi Oka, Ryo Shikimoto, Yoshihiro Noda …

Scientific Reports 10(1) 2020年12月査読有り
アルツハイマー病におけるDNAメチル化量の変化

小林伸行, 品川俊一郎, 永田智行, 互健二, 嶋田和也, 石井梓, 岡直美, 繁田雅弘, 近藤一博

東京慈恵会医科大学雑誌 135(1-6) 30-31 2020年11月
Cooperative activation of the human herpesvirus 6B U79/80 early gene promoter by immediate‐early proteins IE1B and IE2B

Kazuya Shimada, Nobuyuki Kobayashi, Naomi Oka, Mayumi Takahashi, Kazuhiro Kondo

Microbiology and Immunology 64(11) 747-761 2020年11月査読有り筆頭著者責任著者
血液中COASY DNAメチル化量の上昇はアルツハイマー病の初期バイオマーカーとなる

小林伸行, 品川俊一郎, 新村秀人, 喜田恒, 永田智行, 互健二, 嶋田和也, 岡直美, 色本涼, 野田賀大 …

Dementia Japan 34(4) 500-500 2020年10月
Human Herpesvirus 6B Greatly Increases Risk of Depression by Activating Hypothalamic-Pituitary -Adrenal Axis during Latent Phase of Infection.

Nobuyuki Kobayashi, Naomi Oka, Mayumi Takahashi, Kazuya Shimada, Azusa Ishii, Yoshitaka Tatebayashi, Masahiro Shigeta, Hiroyuki Yanagisawa, Kazuhiro Kondo

iScience 23(6) 101187-101187 2020年6月26日査読有り
Attenuation of human herpesvirus 6B reactivation by aging

Kobayashi N, Nishiyama T, Yamauchi T, Shimada K, Suka M, Kondo K, Yanagisawa H

Journal of Medical Virology 91(7) 1335-1341 2019年査読有り
Increased interleukin-1β and basic fibroblast growth factor levels in the cerebrospinal fluid during human herpesvirus-6B (HHV-6B) encephalitis.

Tamai M, Kobayashi N, Shimada K, Oka N, Takahashi M, Tanuma A, Tanemoto T, Namba H, Saito Y, Wada Y …

Biochemical and biophysical research communications 486(3) 706-711 2017年5月査読有り
Usefulness of DNA Methylation Levels in COASY and SPINT1 Gene Promoter Regions as Biomarkers in Diagnosis of Alzheimer's Disease and Amnestic Mild Cognitive Impairment

Nobuyuki Kobayashi, Shunichiro Shinagawa, Tomoyuki Nagata, Kazuya Shimada, Nobuto Shibata, Tohru Ohnuma, Koji Kasanuki, Heii Arai, Hisashi Yamada, Kazuhiko Nakayama …

PLoS One 11(12) e0168816 2016年12月査読有り
Human herpesvirus 6 and 7 are biomarkers for fatigue, which distinguish between physiological fatigue and pathological fatigue

Ryo Aoki, Nobuyuki Kobayashi, Go Suzuki, Hirohiko Kuratsune, Kazuya Shimada, Naomi Oka, Mayumi Takahashi, Wataru Yamadera, Masayuki Iwashita, Shinichi Tokuno …

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 478(1) 424-430 2016年9月査読有り
Development of Biomarkers Based on DNA Methylation in the NCAPH2/LMF2 Promoter Region for Diagnosis of Alzheimer's Disease and Amnesic Mild Cognitive Impairment

Nobuyuki Kobayashi, Shunichiro Shinagawa, Tomoyuki Nagata, Kazuya Shimada, Nobuto Shibata, Tohru Ohnuma, Koji Kasanuki, Heii Arai, Hisashi Yamada, Kazuhiko Nakayama …

PLOS ONE 11(1) e0146449 2016年1月査読有り
Erratum: Increase in the IgG avidity index due to herpes simplex virus type 1 reactivation and its relationship with cognitive function in amnestic mild cognitive impairment and Alzheimer's disease (Biochemical and Biophysical Research Communications (2013) 430 (907-911))

Nobuyuki Kobayashi, Tomoyuki Nagata, Shunichiro Shinagawa, Naomi Oka, Kazuya Shimada, Akihiro Shimizu, Yoshitaka Tatebayashi, Hisashi Yamada, Kazuhiko Nakayama, Kazuhiro Kondo

Biochemical and Biophysical Research Communications 450(1) 925 2014年7月18日査読有り
Novel Gene Therapy Viral Vector Using Non-Oncogenic Lymphotropic Herpesvirus

Akihiro Shimizu, Nobuyuki Kobayashi, Kazuya Shimada, Kuniaki Oura, Tadao Tanaka, Aikou Okamoto, Kazuhiro Kondo

PLoS ONE 8(2) e56027 2013年2月11日査読有り
Establishment of a human embryonic kidney cell line carrying chromosomally integrated human herpesvirus 6B (HHV-6B) using novel recombinant HHV-6B, and analysis of the integration mechanism into human genomic DNA

Akihiro Shimizu, Nobuyuki Kobayashi, Kazuya Shimada, Kazuhiro Kondo

Tokyo Jikeikai Medical Journal 128(1) 41-52 2013年1月15日
Increase in the IgG avidity index due to herpes simplex virus type 1 reactivation and its relationship with cognitive function in amnestic mild cognitive impairment and Alzheimer's disease

Nobuyuki Kobayashi, Tomoyuki Nagata, Shunichiro Shinagawa, Naomi Oka, Kazuya Shimada, Akihiro Shimizu, Yoshitaka Tatebayashi, Hisashi Yamada, Kazuhiko Nakayama, Kazuhiro Kondo

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 430(3) 907-911 2013年1月査読有り