Kazuya Shimada

Profile Information

Affiliation: Jikei University

Degree: Ph.D.(Osaka University)

J-GLOBAL ID: 201801000513420348
researchmap Member ID: B000305945

Research Interests

Research Areas

Life sciences / Virology /

Papers

Identification of a strong genetic risk factor for major depressive disorder in the human virome.

Nobuyuki Kobayashi, Kazuya Shimada, Azusa Ishii, Rui Osaka, Toshiko Nishiyama, Masahiro Shigeta, Hiroyuki Yanagisawa, Naomi Oka, Kazuhiro Kondo

iScience, 27(3) 109203-109203, Mar 15, 2024 Peer-reviewed
SARS-CoV-2 S1 protein causes brain inflammation by reducing intracerebral acetylcholine production

Naomi Oka, Kazuya Shimada, Azusa Ishii, Nobuyuki Kobayashi, Kazuhiro Kondo

iScience, 26(6) 106954-106954, May, 2023 Peer-reviewed
VP26, a herpes simplex virus type 1 capsid protein, increases DNA methylation in COASY promoter region.

Rui Osaka, Nobuyuki Kobayashi, Kazuya Shimada, Azusa Ishii, Naomi Oka, Kazuhiro Kondo

Brain, behavior, & immunity - health, 26 100545-100545, Dec, 2022 Peer-reviewed
SARS-CoV-2 causes brain inflammation via impaired neuro-immune interactions

Naomi Oka, Kazuya Shimada, Azusa Ishii, Nobuyuki Kobayashi, Kazuhiro Kondo

Jul 15, 2022
嗅球に潜伏感染したヒトヘルペスウイルス6の炎症誘導作用

岡直美, 小林伸行, 嶋田和也, 石井梓, 近藤一博

東京慈恵会医科大学雑誌, 136(6) 128-129, Nov, 2021
Blood DNA Methylation Levels in the WNT5A Gene Promoter Region: A Potential Biomarker for Agitation in Subjects with Dementia.

Nobuyuki Kobayashi, Shunichiro Shinagawa, Tomoyuki Nagata, Kenji Tagai, Kazuya Shimada, Azusa Ishii, Naomi Oka, Masahiro Shigeta, Kazuhiro Kondo

Journal of Alzheimer's disease : JAD, 81(4) 1601-1611, 2021 Peer-reviewed
Increased blood COASY DNA methylation levels a potential biomarker for early pathology of Alzheimer’s disease

Nobuyuki Kobayashi, Shunichiro Shinagawa, Hidehito Niimura, Hisashi Kida, Tomoyuki Nagata, Kenji Tagai, Kazuya Shimada, Naomi Oka, Ryo Shikimoto, Yoshihiro Noda …

Scientific Reports, 10(1), Dec, 2020 Peer-reviewed
アルツハイマー病におけるDNAメチル化量の変化

小林伸行, 品川俊一郎, 永田智行, 互健二, 嶋田和也, 石井梓, 岡直美, 繁田雅弘, 近藤一博

東京慈恵会医科大学雑誌, 135(1-6) 30-31, Nov, 2020
Cooperative activation of the human herpesvirus 6B U79/80 early gene promoter by immediate‐early proteins IE1B and IE2B

Kazuya Shimada, Nobuyuki Kobayashi, Naomi Oka, Mayumi Takahashi, Kazuhiro Kondo

Microbiology and Immunology, 64(11) 747-761, Nov, 2020 Peer-reviewedLead authorCorresponding author
血液中COASY DNAメチル化量の上昇はアルツハイマー病の初期バイオマーカーとなる

小林伸行, 品川俊一郎, 新村秀人, 喜田恒, 永田智行, 互健二, 嶋田和也, 岡直美, 色本涼, 野田賀大 …

Dementia Japan, 34(4) 500-500, Oct, 2020
Human Herpesvirus 6B Greatly Increases Risk of Depression by Activating Hypothalamic-Pituitary -Adrenal Axis during Latent Phase of Infection.

Nobuyuki Kobayashi, Naomi Oka, Mayumi Takahashi, Kazuya Shimada, Azusa Ishii, Yoshitaka Tatebayashi, Masahiro Shigeta, Hiroyuki Yanagisawa, Kazuhiro Kondo

iScience, 23(6) 101187-101187, Jun 26, 2020 Peer-reviewed
Attenuation of human herpesvirus 6B reactivation by aging.

Nobuyuki Kobayashi, Toshiko Nishiyama, Takashi Yamauchi, Kazuya Shimada, Machi Suka, Kazuhiro Kondo, Hiroyuki Yanagisawa

Journal of medical virology, 91(7) 1335-1341, 2019 Peer-reviewed
Increased interleukin-1 beta and basic fibroblast growth factor levels in the cerebrospinal fluid during human herpesvirus-6B (HHV-6B) encephalitis

Masato Tamai, Nobuyuki Kobayashi, Kazuya Shimada, Naomi Oka, Mayumi Takahashi, Akiko Tanuma, Tomohiro Tanemoto, Hiroyuki Namba, Yoshihiro Saito, Yasuyuki Wada …

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 486(3) 706-711, May, 2017 Peer-reviewed
Usefulness of DNA Methylation Levels in COASY and SPINT1 Gene Promoter Regions as Biomarkers in Diagnosis of Alzheimer's Disease and Amnestic Mild Cognitive Impairment

Nobuyuki Kobayashi, Shunichiro Shinagawa, Tomoyuki Nagata, Kazuya Shimada, Nobuto Shibata, Tohru Ohnuma, Koji Kasanuki, Heii Arai, Hisashi Yamada, Kazuhiko Nakayama …

PLoS One, 11(12) e0168816, Dec, 2016 Peer-reviewed
Human herpesvirus 6 and 7 are biomarkers for fatigue, which distinguish between physiological fatigue and pathological fatigue

Ryo Aoki, Nobuyuki Kobayashi, Go Suzuki, Hirohiko Kuratsune, Kazuya Shimada, Naomi Oka, Mayumi Takahashi, Wataru Yamadera, Masayuki Iwashita, Shinichi Tokuno …

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 478(1) 424-430, Sep, 2016 Peer-reviewed
Development of Biomarkers Based on DNA Methylation in the NCAPH2/LMF2 Promoter Region for Diagnosis of Alzheimer's Disease and Amnesic Mild Cognitive Impairment

Nobuyuki Kobayashi, Shunichiro Shinagawa, Tomoyuki Nagata, Kazuya Shimada, Nobuto Shibata, Tohru Ohnuma, Koji Kasanuki, Heii Arai, Hisashi Yamada, Kazuhiko Nakayama …

PLOS ONE, 11(1) e0146449, Jan, 2016 Peer-reviewed
Erratum: Increase in the IgG avidity index due to herpes simplex virus type 1 reactivation and its relationship with cognitive function in amnestic mild cognitive impairment and Alzheimer's disease (Biochemical and Biophysical Research Communications (2013) 430 (907-911))

Nobuyuki Kobayashi, Tomoyuki Nagata, Shunichiro Shinagawa, Naomi Oka, Kazuya Shimada, Akihiro Shimizu, Yoshitaka Tatebayashi, Hisashi Yamada, Kazuhiko Nakayama, Kazuhiro Kondo

Biochemical and Biophysical Research Communications, 450(1) 925, Jul 18, 2014 Peer-reviewed
Novel Gene Therapy Viral Vector Using Non-Oncogenic Lymphotropic Herpesvirus

Akihiro Shimizu, Nobuyuki Kobayashi, Kazuya Shimada, Kuniaki Oura, Tadao Tanaka, Aikou Okamoto, Kazuhiro Kondo

PLoS ONE, 8(2) e56027, Feb 11, 2013 Peer-reviewed
Increase in the IgG avidity index due to herpes simplex virus type 1 reactivation and its relationship with cognitive function in amnestic mild cognitive impairment and Alzheimer's disease

Nobuyuki Kobayashi, Tomoyuki Nagata, Shunichiro Shinagawa, Naomi Oka, Kazuya Shimada, Akihiro Shimizu, Yoshitaka Tatebayashi, Hisashi Yamada, Kazuhiko Nakayama, Kazuhiro Kondo

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 430(3) 907-911, Jan, 2013 Peer-reviewed
Human herpesvirus 6 immediate-early 2 protein interacts with heterogeneous ribonucleoprotein K and casein kinase 2

K Shimada, K Kondo, K Yamanishi

MICROBIOLOGY AND IMMUNOLOGY, 48(3) 205-210, 2004 Peer-reviewedLead author

Misc.

Molecular pathological studies on Alzheimer’s disease and human herpesvirus infections

小林伸行, 小坂瑠衣, 嶋田和也, 石井梓, 岡直美, 村山繁雄, 齊藤祐子, 近藤一博

日本ウイルス学会学術集会プログラム・予稿集(Web), 70th, 2023
Changes in blood DNA methylation in Alzheimer’s disease.

小林伸行, 品川俊一郎, 永田智行, 互健二, 嶋田和也, 石井梓, 岡直美, 繁田雅弘, 近藤一博

東京慈恵会医科大学雑誌, 135(1/6), 2020
Activating transcription factor 3 (ATF3) as a perspective biomarker of Crohn’s disease

Kobayashi Nobuyuki, Arihiro Seiji, Shimada Kazuya, Hoshino Atsushi, Saijo Hiroki, Oka Naomi, Saruta Masayuki, Kondo Kazuhiro

European Journal of Inflammation, 18, 2020
ヒトヘルペスウイルス6B(HHV-6B)前初期遺伝子IE2とスプライシング関連因子SART3によるie1/ie2遺伝子の転写後調節

嶋田和也, 小林伸行, 岡直美, 高橋麻弓, 近藤一博

日本ウイルス学会学術集会プログラム・予稿集(Web), 67th, 2019
Posttranscriptional regulation of human herpesvirus 6 immediate-early 1 and 2 genes by immediate-early 2 and splicing factor squamous cell carcinoma antigen recognized by T cells 3.

嶋田和也, 小林伸行, 岡直美, 高橋麻弓, 近藤一博

東京慈恵会医科大学雑誌, 134(6), 2019
乳酸が疲労の発生および疲労回復に与える影響の解析

岡直美, 小林伸行, 高橋麻弓, 嶋田和也, 近藤一博

日本疲労学会誌, 14(1) 43-43, May, 2018
運動負荷及びうつ病患者における疲労の分子機構eIF2αリン酸化関連シグナルの検討

小林伸行, 岡直美, 高橋麻弓, 嶋田和也, 近藤一博

日本疲労学会誌, 14(1) 44-44, May, 2018
脳に潜伏するHHV-6はストレスを増幅してうつ病のリスクを上昇させる

岡直美, 小林伸行, 高橋麻弓, 嶋田和也, 近藤一博

東京慈恵会医科大学雑誌, 133(6), 2018
疲労を引き起こす分子メカニズムの解明

小林伸行, 岡直美, 高橋麻弓, 嶋田和也, 近藤一博

東京慈恵会医科大学雑誌, 132(6) 142-143, Nov, 2017
さまざまな変性性認知症疾患におけるDNAメチル化変化とその臨床的意義の検討

小林伸行, 品川俊一郎, 永田智行, 嶋田和也, 柴田展人, 大沼徹, 笠貫浩史, 新井平伊, 繁田雅弘, 近藤一博

Dementia Japan, 31(4) 628-628, Oct, 2017
疲労によって誘導されるウイルス因子が関与するうつ病発症メカニズムの解明

岡直美, 小林伸行, 高橋麻弓, 嶋田和也, 近藤一博

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, 39回・47回 166-166, Sep, 2017
唾液中に分泌されたHHV-6がうつ病を発症させるメカニズムの解明

岡直美, 小林伸行, 高橋麻弓, 嶋田和也, 近藤一博

日本疲労学会誌, 13(1) 65-65, May, 2017
分子機構から明らかにする疲労とストレスとの相違に関する検討

小林伸行, 岡直美, 高橋麻弓, 玉井将人, 嶋田和也, 近藤一博

日本疲労学会誌, 13(1) 88-88, May, 2017
Interleukin 1β and basic fibroblast growth factor promote viral proliferation in human herpesvirus 6B encephalitis

131(6) 156-157, Nov 15, 2016
HHV-6B脳炎において、interleukin-1βとbasic fibroblast growth factorはウイルスの増殖因子となる

玉井将人, 小林伸行, 嶋田和也, 岡直美, 高橋麻弓, 齋藤義弘, 和田靖之, 岡本愛光, 井田博幸, 近藤一博

東京慈恵会医科大学雑誌, 131(6) 156-157, Nov, 2016
血液中DNAメチル化変化を利用したアルツハイマー病と軽度認知機能障害の新規診断法に関する検討

小林伸行, 品川俊一郎, 永田智行, 嶋田和也, 柴田展人, 大沼徹, 笠貫浩史, 新井平伊, 山田尚, 中山和彦 …

老年精神医学雑誌, 27(増刊II) 179-179, Jun, 2016
唾液中ヒトヘルペスウイルス(HHV-)6及びHHV-7量による病的疲労と生理的疲労との鑑別に関する検討

小林伸行, 青木亮, 岡直美, 佐藤麻弓, 嶋田和也, 玉井将人, 玉井将人, 山寺亘, 岩下正幸, 倉恒弘彦 …

日本疲労学会誌, 12(1), 2016
ヒトサイトメガロウイルス(HCMV)潜伏感染タンパク質ORF152が神経機能に与える影響

嶋田和也, 小林伸行, 岡直美, 玉井将人, 近藤一博

東京慈恵会医科大学雑誌, 130(6) 159-159, Nov, 2015
唾液中に分泌されたヒトヘルペスウイルス(HHV)-6がうつ病を発症させるメカニズムの解明

岡直美, 小林伸行, 嶋田和也, 近藤一博

東京慈恵会医科大学雑誌, 129(6) 202-203, Nov, 2014
Increase in the IgG avidity index due to herpes simplex virus type 1 reactivation and its relationship with cognitive function in amnestic mild cognitive impairment and Alzheimer's disease (vol 430, pg 907, 2013)

Nobuyuki Kobayashi, Tomoyuki Nagata, Shunichiro Shinagawa, Naomi Oka, Kazuya Shimada, Akihiro Shimizu, Yoshitaka Tatebayashi, Hisashi Yamada, Kazuhiko Nakayama, Kazuhiro Kondo

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 450(1) 925-925, Jul, 2014

Presentations

ORF152は先天性CMV感染症において神経病原性を誘導する

嶋田和也, 小林伸行, 岡直美, 石井梓, 近藤一博

第69回日本ウイルス学会学術総会, Nov, 2022
CMV潜伏感染関連タンパク質ORF152による先天性CMV感染症発症機序の解明

嶋田和也, 小林伸行, 岡直美, 石井梓, 近藤一博

第68回日本ウイルス学会学術総会, Nov, 2021
Post-transcriptional Regulation of human herpesvirus 6 immediate-early 1 and 2 genes by Immediate-Early 2 and splicing factor SART3

Kazuya Shimada, Nobuyuki Kobayashi, Naomi Oka, Mayumi Takahashi, Kazuhiro Kondo

The 67th Annual Meeting of the Japanese Society for Virology(Tokyo), Oct, 2019
Post-transcriptional regulation of human herpesvirus 6 immediate-early 1 and 2 genes by Immediate-Early 2 and splicing factor SART3

嶋田和也, 小林伸行, 岡直美, 髙橋麻弓, 近藤一博

第33回ヘルペスウイルス研究会(那覇), Jun, 2019
Human Cytomegalovirus (HCMV) Latency-Associated Protein ORF152 Induces Neuropathogenesis of Congenital CMV Infection

Kazuya Shimada, Nobuyuki Kobayashi, Naomi Oka, Mayumi Takahashi, Kazuhiro Kondo

The 66th Annual Meeting of the Japanese Society for Virology(Kyoto), Oct, 2018
CMV潜伏感染タンパク質ORF152による先天性CMV感染症発症機序の解明

嶋田和也, 小林伸行, 岡直美, 髙橋麻弓, 近藤一博

第32回ヘルペスウイルス研究会(福岡), Jun, 2018
Human Cytomegalovirus (HCMV) Latency-Associated Protein ORF152 Is Associated with Pathogenesis of Congenital CMV Infection

Kazuya SHIMADA, Nobuyuki KOBAYASHI, Naomi OKA, Masato TAMAI, Mayumi Takahashi, Kazuhiro KONDO

The 65th Annual Meeting of the Japanese Society for Virology(Osaka), Oct, 2017
ヒトサイトメガロウイルスの潜伏感染タンパク質ORF152が潜伏感染・再活性化と細胞分化に与える影響

嶋田和也, 大澤正亨, 小林伸行, 岡直美, 髙橋麻弓, 近藤一博

第31回ヘルペスウイルス研究会, Jun, 2017
"Human herpesvirus 6 (HHV-) and HHV-7 reactivation in fatigue, which distinguishes between physiological fatigue and pathological fatigue."

Nobuyuki Kobayashi, Ryo Aoki, Hirohiko Kuratsune, Naomi Oka, Mayumi Takahashi, Kazuya Shimada, Wataru Yamadera, Masayuki Iwashita, Hiroshi Ito, Kazuhiko Nakayama, Kazuhiro Kondo

"The 64th Annual Meeting of the Japanese Society for Virology(Sapporo)", Oct, 2016
"Human Cytomegalovirus (HCMV) Latency-Associated Protein ORF152 Induces Pathogenesis of Congenital CMV Infection"

Kazuya Shimada

"The 64th Annual Meeting of the Japanese Society for Virology(Sapporo)", Oct, 2016
CMV潜伏タンパク質ORF152 による先天性CMV感染症発症機序の解明

嶋田和也, 小林伸行, 岡直美, 玉井将人, 高橋麻弓, 近藤一博

第30回ヘルペスウイルス研究会(府中), Jun, 2016
"Human Cytomegalovirus (HCMV) Latency-Associated Protein ORF152 Induces Calcium Influx and Inhibits Gene Expression in Central Nervous System"

Kazuya Shimada

"The 63rd Annual Meeting of the Japanese society for virology(福岡市)", Nov, 2015
"Human Cytomegalovirus (HCMV) Latency-Associated Protein ORF152 Induces Calcium Signaling and Promotes Differentiation of Myeloid Progenitor Cells."

Kazuya Shimada

"The 39th Annual International Herpesvirus Workshop(Kobe)", Jul, 2014
"Roles of Human Herpesvirus 6 Immediate-early 2 protein and Splicing factor SART3 in Cellular Tropism"

Kazuya Shimada

"Interntional Union of Microbioligical Societies 2011 Congress(Sapporo)", Sep, 2011
"Alternative splicing regulation of human herpesvirus 6 (HHV-6) ie1/ie2 genes by immediate-early 2 (IE2) and splicing factor SART3"

Kazuya Shimada

"14th International conference on immunobiology and prophylaxis of human herpesvirus infections(神戸)", Oct, 2009
血液中DNAメチル化変化を利用したアルツハイマー病と軽度認知機能障害の新規診断法に関する検討

小林伸行, 品川俊一郎, 永田智行, 嶋, 田和也, 柴田展人, 大沼徹, 笠貫浩史, 新井平伊, 山田尚, 中山和彦, 近藤一博

第31回日本老年精神医学会(金沢)
唾液中ヒトヘルペスウイルス(HHV-)6及びHHV-7量による病的疲労と生理的疲労との鑑別に関する検討

小林伸行, 青木亮, 岡直美, 橋麻弓, 嶋田和也, 玉井将人, 山寺亘, 岩下正, 幸, 倉恒弘彦, 伊藤洋, 中山和彦, 近藤, 一博

第12回日本疲労学会 (横浜)
睡眠時無呼吸症候群を対象とした、HHV-6、HHV-7の再活性化メカニズムの検討.

小林伸行, 青木亮, 嶋田和也, 玉井将人, 山寺亘, 岩下正幸, 伊藤洋, 中山和彦, 近藤一博

第63回日本ウイルス学会(福岡)
HCMV潜伏感染タンパク質 ORF152が神経機能に与える影響.

嶋田和也, 小林伸行, 岡直美, 玉井将人, 近藤一博

第29回ヘルペスウイルス研究会(長崎市)
ヒトサイトメガロウイルスの潜伏感染タンパク質 ORF152が潜伏感染・再活性化に与える影響

嶋田和也, 小林伸行, 岡直美, 大澤正亨, 近藤一博

第62回日本ウイルス学会学術集会(横浜)

Professional Memberships

THE JAPANESE SOCIETY FOR VIROLOGY

Research Projects

先天性サイトメガロウイルス感染症発症機序の解明と長期観察モデルマウスの開発

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

嶋田和也
Elucidation of congenital CMV infection mechanisms and development of prevention

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Shimada Kazuya

Profile Information

Research Interests

Research Areas

Papers

Misc.

Presentations

Professional Memberships

Research Projects

Menu

Coauthors