2012年6月
Apparent diffusion coefficient correlation with oesophageal tumour stroma and angiogenesis
EUROPEAN RADIOLOGY
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- 巻
- 22
- 号
- 6
- 開始ページ
- 1172
- 終了ページ
- 1177
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s00330-011-2359-0
- 出版者・発行元
- SPRINGER
Objective Because diffusion-weighted imaging (DWI) can predict the prognosis of patients with oesophageal squamous cell carcinoma (ESCC), we hypothesised that apparent diffusion coefficient (ADC) values might be correlated with the collagen content and tumour angiogenesis. The purpose of this study was to determine the correlation between ADC values of ESCC before treatment and oesophageal tumour stroma and angiogenesis.
Methods Seventeen patients with ESCC were enrolled. The ADC values were calculated from the DWI score. Seventeen patients who had undergone oesophagectomy were analysed for tumour stroma, vascular endothelial growth factor (VEGF) and CD34. Tissue collagen was stained with azocarmine and aniline blue to quantitatively analyse the extracellular matrix in cancer stroma. Tissues were stained with VEGF and CD34 to analyse the angiogenesis.
Results The ADC values decreased with stromal collagen growth. We found a negative correlation between the tumour ADC and the amount of stromal collagen ( = -0.729, = 0.001), i.e. the ADC values decreased with growth of VEGF. We also found a negative correlation between the ADC of the tumours and the amount of VEGF (r = 0.538, = 0.026).
Conclusion Our results indicated that the ADC value may be a novel prognostic factor and contribute to the treatment of oesophageal cancer.
Key Points
Magnetic resonance apparent diffusion coefficient values inversely indicate tumour stromal collagen
There is also negative correlation between ADCs and vascular endothelial growth factor
ADC values may contribute to the treatment of oesophageal cancer.
Methods Seventeen patients with ESCC were enrolled. The ADC values were calculated from the DWI score. Seventeen patients who had undergone oesophagectomy were analysed for tumour stroma, vascular endothelial growth factor (VEGF) and CD34. Tissue collagen was stained with azocarmine and aniline blue to quantitatively analyse the extracellular matrix in cancer stroma. Tissues were stained with VEGF and CD34 to analyse the angiogenesis.
Results The ADC values decreased with stromal collagen growth. We found a negative correlation between the tumour ADC and the amount of stromal collagen ( = -0.729, = 0.001), i.e. the ADC values decreased with growth of VEGF. We also found a negative correlation between the ADC of the tumours and the amount of VEGF (r = 0.538, = 0.026).
Conclusion Our results indicated that the ADC value may be a novel prognostic factor and contribute to the treatment of oesophageal cancer.
Key Points
Magnetic resonance apparent diffusion coefficient values inversely indicate tumour stromal collagen
There is also negative correlation between ADCs and vascular endothelial growth factor
ADC values may contribute to the treatment of oesophageal cancer.
- リンク情報
- ID情報
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- DOI : 10.1007/s00330-011-2359-0
- ISSN : 0938-7994
- PubMed ID : 22258519
- Web of Science ID : WOS:000303876100004