論文

査読有り
2012年6月

Apparent diffusion coefficient correlation with oesophageal tumour stroma and angiogenesis

EUROPEAN RADIOLOGY
  • Tomoyoshi Aoyagi
  • ,
  • Kiyohiko Shuto
  • ,
  • Shinichi Okazumi
  • ,
  • Kohichi Hayano
  • ,
  • Asami Satoh
  • ,
  • Hiroshige Saitoh
  • ,
  • Hideaki Shimada
  • ,
  • Yoshihiro Nabeya
  • ,
  • Toshiki Kazama
  • ,
  • Hisahiro Matsubara

22
6
開始ページ
1172
終了ページ
1177
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00330-011-2359-0
出版者・発行元
SPRINGER

Objective Because diffusion-weighted imaging (DWI) can predict the prognosis of patients with oesophageal squamous cell carcinoma (ESCC), we hypothesised that apparent diffusion coefficient (ADC) values might be correlated with the collagen content and tumour angiogenesis. The purpose of this study was to determine the correlation between ADC values of ESCC before treatment and oesophageal tumour stroma and angiogenesis.
Methods Seventeen patients with ESCC were enrolled. The ADC values were calculated from the DWI score. Seventeen patients who had undergone oesophagectomy were analysed for tumour stroma, vascular endothelial growth factor (VEGF) and CD34. Tissue collagen was stained with azocarmine and aniline blue to quantitatively analyse the extracellular matrix in cancer stroma. Tissues were stained with VEGF and CD34 to analyse the angiogenesis.
Results The ADC values decreased with stromal collagen growth. We found a negative correlation between the tumour ADC and the amount of stromal collagen ( = -0.729, = 0.001), i.e. the ADC values decreased with growth of VEGF. We also found a negative correlation between the ADC of the tumours and the amount of VEGF (r = 0.538, = 0.026).
Conclusion Our results indicated that the ADC value may be a novel prognostic factor and contribute to the treatment of oesophageal cancer.
Key Points
Magnetic resonance apparent diffusion coefficient values inversely indicate tumour stromal collagen
There is also negative correlation between ADCs and vascular endothelial growth factor
ADC values may contribute to the treatment of oesophageal cancer.

リンク情報
DOI
https://doi.org/10.1007/s00330-011-2359-0
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/22258519
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000303876100004&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s00330-011-2359-0
  • ISSN : 0938-7994
  • PubMed ID : 22258519
  • Web of Science ID : WOS:000303876100004

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