2013年9月
Evaluation of Oxidized-Low-Density Lipoproteins Using Kelvin Force Microscopy
IEEE SENSORS JOURNAL
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- 巻
- 13
- 号
- 9
- 開始ページ
- 3449
- 終了ページ
- 3453
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1109/JSEN.2013.2265014
- 出版者・発行元
- IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
Oxidized-low-density lipoprotein (ox-LDL), which is generated by LDL oxidation, is a risk factor of cardiovascular disease development. LDL has positive charges on the surface attributable to amino groups of lysine moieties on Apo B-100. Its positive charge is decreased by oxidation. For this paper, the topography and surface potential of LDL and ox-LDL are measured using atomic force microscopy and Kelvin probe force microscopy (KPFM). Although it is difficult to ascertain a difference between topographic images of LDL and ox-LDL, the KPFM images of ox-LDL differ from those obtained using LDL. The averaged potential of the surface decreases concomitantly with increasing oxidation time of the LDL. We demonstrate a method to evaluate the oxidation level of LDL using KPFM.
- リンク情報
- ID情報
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- DOI : 10.1109/JSEN.2013.2265014
- ISSN : 1530-437X
- J-Global ID : 201302253718455600
- Web of Science ID : WOS:000323217400017