Kenji Sugata - My portal

Profile Information

Affiliation: Joint Research Center for Human Retrovirus Infection, Kumamoto University

Degree: PhD(Kyoto University)

Researcher number: 10650616
J-GLOBAL ID: 202101001598990018
researchmap Member ID: R000030584

Research Areas

Research History

Apr, 2023 - Present

Kumamoto University
Apr, 2022 - Mar, 2023

Kumamoto University
Apr, 2020 - Mar, 2022

Kumamoto University
Apr, 2016 - Mar, 2020

Research fellow, プリンセスマーガレットがんセンター
Apr, 2013 - Mar, 2016

特別研究員（PD）, 日本学術振興会
Apr, 2012 - Mar, 2013

Kyoto University

Awards

Papers

HIV-Tocky system to visualize proviral expression dynamics

Omnia Reda, Kazuaki Monde, Kenji Sugata, Akhinur Rahman, Wajihah Sakhor, Samiul Alam Rajib, Sharmin Nahar Sithi, Benjy Jek Yang Tan, Koki Niimura, Chihiro Motozono …

Communications Biology, 7(1), Mar 20, 2024
Association of Clostridium butyricum Therapy Using the Live Bacterial Product CBM588 with the Survival of Patients with Lung Cancer Receiving Chemoimmunotherapy Combinations.

Yusuke Tomita, Shinya Sakata, Kosuke Imamura, Shinji Iyama, Takayuki Jodai, Koichi Saruwatari, Shohei Hamada, Kimitaka Akaike, Moriyasu Anai, Kazuaki Fukusima …

Cancers, 16(1), Dec 21, 2023
Understanding the Immunopathology of HTLV-1-Associated Adult T-Cell Leukemia/Lymphoma: A Comprehensive Review.

Shingo Nakahata, Daniel Enriquez-Vera, M Ishrat Jahan, Kenji Sugata, Yorifumi Satou

Biomolecules, 13(10), Oct 19, 2023
Clone Dynamics and Its Application for the Diagnosis of Enzootic Bovine Leukosis.

Md Belal Hossain, Tomoko Kobayashi, Sakurako Makimoto, Misaki Matsuo, Kohei Nishikaku, Benjy Jek Yang Tan, Akhinur Rahman, Samiul Alam Rajib, Kenji Sugata, Nagaki Ohnuki …

Journal of virology, 97(1) e0154222, Jan 31, 2023
Modification of the HLA-A*24:02 Peptide Binding Pocket Enhances Cognate Peptide-Binding Capacity and Antigen-Specific T Cell Activation.

Kenji Murata, Dalam Ly, Hiroshi Saijo, Yukiko Matsunaga, Kenji Sugata, Fumie Ihara, Daisuke Oryoji, Yota Ohashi, Kayoko Saso, Chung-Hsi Wang …

Journal of immunology (Baltimore, Md. : 1950), 209(8) 1481-1491, Sep 9, 2022
Identification and characterization of a novel enhancer in the HTLV-1 proviral genome.

Misaki Matsuo, Takaharu Ueno, Kazuaki Monde, Kenji Sugata, Benjy Jek Yang Tan, Akhinur Rahman, Paola Miyazato, Kyosuke Uchiyama, Saiful Islam, Hiroo Katsuya …

Nature communications, 13(1) 2405-2405, May 3, 2022
HTLV-1 persistence and leukemogenesis: A game of hide-and-seek with the host immune system.

Benjy J Y Tan, Kenji Sugata, Masahiro Ono, Yorifumi Satou

Frontiers in immunology, 13 991928-991928, 2022
A widely distributed HIV-1 provirus elimination assay to evaluate latency-reversing agents in vitro.

Kouki Matsuda, Saiful Islam, Toru Takada, Kiyoto Tsuchiya, Benjy Jek Yang Tan, Shin-Ichiro Hattori, Hiroo Katsuya, Kosaku Kitagawa, Kwang Su Kim, Misaki Matsuo …

Cell reports methods, 1(8) 100122-100122, Dec 20, 2021
HTLV-1 infection promotes excessive T cell activation and transformation into adult T cell leukemia/lymphoma.

Benjy Jy Tan, Kenji Sugata, Omnia Reda, Misaki Matsuo, Kyosuke Uchiyama, Paola Miyazato, Vincent Hahaut, Makoto Yamagishi, Kaoru Uchimaru, Yutaka Suzuki …

The Journal of clinical investigation, 131(24), Dec 15, 2021
Affinity-matured HLA class II dimers for robust staining of antigen-specific CD4+ T cells.

Kenji Sugata, Yukiko Matsunaga, Yuki Yamashita, Munehide Nakatsugawa, Tingxi Guo, Levon Halabelian, Yota Ohashi, Kayoko Saso, Muhammed A Rahman, Mark Anczurowski …

Nature biotechnology, 39(8) 958-967, Aug, 2021
In vivo dynamics and adaptation of HTLV-1-infected clones under different clinical conditions.

Mikiko Izaki, Jun-Ichirou Yasunaga, Kisato Nosaka, Kenji Sugata, Hayato Utsunomiya, Youko Suehiro, Takafumi Shichijo, Asami Yamada, Yasuhiko Sugawara, Taizo Hibi …

PLoS pathogens, 17(2) e1009271, Feb, 2021
Genetic Ablation of HLA Class I, Class II, and the T-cell Receptor Enables Allogeneic T Cells to Be Used for Adoptive T-cell Therapy.

Yuki Kagoya, Tingxi Guo, Brian Yeung, Kayoko Saso, Mark Anczurowski, Chung-Hsi Wang, Kenji Murata, Kenji Sugata, Hiroshi Saijo, Yukiko Matsunaga …

Cancer immunology research, 8(7) 926-936, Jul, 2020
Landscape mapping of shared antigenic epitopes and their cognate TCRs of tumor-infiltrating T lymphocytes in melanoma.

Kenji Murata, Munehide Nakatsugawa, Muhammed A Rahman, Linh T Nguyen, Douglas G Millar, David T Mulder, Kenji Sugata, Hiroshi Saijo, Yukiko Matsunaga, Yuki Kagoya …

eLife, 9, Apr 21, 2020
Chaperones of the class I peptide-loading complex facilitate the constitutive presentation of endogenous antigens on HLA-DP84GGPM87.

Mark Anczurowski, Kenji Sugata, Yukiko Matsunaga, Yuki Yamashita, Chung-Hsi Wang, Tingxi Guo, Kenji Murata, Hiroshi Saijo, Yuki Kagoya, Kayoko Saso …

Journal of autoimmunity, 102 114-125, Aug, 2019
Arginine methylation of FOXP3 is crucial for the suppressive function of regulatory T cells.

Yuki Kagoya, Hiroshi Saijo, Yukiko Matsunaga, Tingxi Guo, Kayoko Saso, Mark Anczurowski, Chung-Hsi Wang, Kenji Sugata, Kenji Murata, Marcus O Butler …

Journal of autoimmunity, 97 10-21, Feb, 2019
Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo.

Rie Furuta, Jun-Ichirou Yasunaga, Michi Miura, Kenji Sugata, Akatsuki Saito, Hirofumi Akari, Takaharu Ueno, Norihiro Takenouchi, Jun-Ichi Fujisawa, Ki-Ryang Koh …

PLoS pathogens, 13(11) e1006722, Nov, 2017
HTLV-1 Viral Factor HBZ Induces CCR4 to Promote T-cell Migration and Proliferation.

Kenji Sugata, Jun-Ichirou Yasunaga, Haruka Kinosada, Yuichi Mitobe, Rie Furuta, Mohamed Mahgoub, Chiho Onishi, Kazutaka Nakashima, Koichi Ohshima, Masao Matsuoka

Cancer research, 76(17) 5068-79, Sep 1, 2016
Impact of the SCF signaling pathway on leukemia stem cell-mediated ATL initiation and progression in an HBZ transgenic mouse model.

Wakako Kuribayashi, Kazuya Takizawa, Kenji Sugata, Madoka Kuramitsu, Haruka Momose, Eita Sasaki, Yuki Hiradate, Keiko Furuhata, Yoshihisa Asada, Atsushi Iwama …

Oncotarget, 7(32) 51027-51043, Aug 9, 2016
Enhancement of anti-STLV-1/HTLV-1 immune responses through multimodal effects of anti-CCR4 antibody.

Kenji Sugata, Jun-Ichirou Yasunaga, Michi Miura, Hirofumi Akari, Atae Utsunomiya, Kisato Nosaka, Yuko Watanabe, Hitoshi Suzushima, Ki-Ryang Koh, Masanori Nakagawa …

Scientific reports, 6 27150-27150, Jun 2, 2016
HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT).

Keiko Yasuma, Jun-ichirou Yasunaga, Keiko Takemoto, Kenji Sugata, Yuichi Mitobe, Norihiro Takenouchi, Masanori Nakagawa, Yutaka Suzuki, Masao Matsuoka

PLoS pathogens, 12(1) e1005372, Jan, 2016

Misc.

HTLV-1による成人T細胞白血病・リンパ腫の発症機構

菅田謙治, 佐藤賢文

日本臨牀 81 (増刊号3) 7-12, 2023., 2023
【リンパ腫学-最新の研究動向-】リンパ腫の疫学と危険因子 HTLV-1感染の疫学と病原性発現機構

菅田謙治, 松岡雅雄

日本臨床, 73(増刊8 リンパ腫学) 49-54, Oct, 2015

Professional Memberships

2021 - Present

日本HTLV-1学会
2020 - Present

日本がん免疫学会
2008 - Present

日本ウイルス学会

Research Projects

Characterization of HTLV-1 specific CTLs detected in HAM patients

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
Comprehensive detection of high affinity TCRs specific for HTLV-1

Grants-in-Aid for Scientific Research, Grant-in-Aid for Research Activity Start-up, Japan Society for the Promotion of Science, Sep, 2020 - Mar, 2022

Sugata Kenji
Characterization of HBZ specific T cells for new anti-HTLV-1 therapy

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

SUGATA Kenji
組換えワクシニアウイルスを用いた抗ＨＴＬＶ－１ワクチンの開発

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, Apr, 2013 - Mar, 2016

菅田謙治