2022年
Neural synchronization analysis of electroencephalography coherence in patients with Parkinson's disease-related mild cognitive impairment.
Clinical parkinsonism & related disorders
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- 巻
- 6
- 号
- 開始ページ
- 100140
- 終了ページ
- 100140
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.prdoa.2022.100140
Introduction: The underlying pathophysiology of slight cognitive dysfunction in Parkinson's disease-related mild cognitive impairment (PD-MCI) is yet to be elucidated. Our study aimed to evaluate the association between cognitive function and brain functional connectivity (FC) in patients with PD-MCI. Methods: Twenty patients with sporadic PD-MCI were evaluated for FC in the brain network. Further, electroencephalography (EEG) coherence analysis in the whole-brain and quantified regional coherence using phase coupling were performed for each frequency, and motor and cognitive function were assessed in the whole-brain. Results: The degree of cognitive impairment was related to a decrease in the coherence in the alpha ranges. The regional coherence in the left frontal-left parietal region rather than the right frontal-right parietal region showed a higher correlation with the cognitive function scores. Conclusion: The differences in EEG coherence across different types of cognitive dysfunction reflect a compensatory response to the heterogeneous and complex clinical presentation of PD-MCI. Our findings indicate decreased brain efficiency and impaired neural synchronization in PD-MCI; these results may be crucial in elucidating the pathological exacerbation of PD-MCI.
- リンク情報
- ID情報
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- DOI : 10.1016/j.prdoa.2022.100140
- PubMed ID : 35308256
- PubMed Central 記事ID : PMC8928128