2012年5月
Bornavirus Closely Associates and Segregates with Host Chromosomes to Ensure Persistent Intranuclear Infection
CELL HOST & MICROBE
- 巻
- 11
- 号
- 5
- 開始ページ
- 492
- 終了ページ
- 503
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.chom.2012.04.009
- 出版者・発行元
- CELL PRESS
Bornaviruses are nonsegmented negative-strand RNA viruses that establish a persistent infection in the nucleus and occasionally integrate a DNA genome copy into the host chromosomal DNA. However, how these viruses achieve intranuclear infection remains unclear. We show that Borna disease virus (BDV), a mammalian bornavirus, closely associates with the cellular chromosome to ensure intranuclear infection. BDV generates viral factories within the nucleus using host chromatin as a scaffold. In addition, the viral ribonucleoprotein (RNP) interacts directly with the host chromosome throughout the cell cycle, using core histones as a docking platform. HMGB1, a host chromatin-remodeling DNA architectural protein, is required to stabilize RNP on chromosomes and for efficient BDV RNA transcription in the nucleus. During metaphase, the association of RNP with mitotic chromosomes allows the viral RNA to segregate into daughter cells and ensure persistent infection. Thus, bornaviruses likely evolved a chromosome-dependent life cycle to achieve stable intranuclear infection.
- リンク情報
-
- DOI
- https://doi.org/10.1016/j.chom.2012.04.009
- CiNii Articles
- http://ci.nii.ac.jp/naid/120004161070
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/22607802
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000304794500010&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.1016/j.chom.2012.04.009
- ISSN : 1931-3128
- CiNii Articles ID : 120004161070
- PubMed ID : 22607802
- Web of Science ID : WOS:000304794500010