論文

査読有り 国際誌
2017年3月26日

Serum Endocan as a Predictive Marker for Decreased Urine Volume in Peritoneal Dialysis Patients.

Medical science monitor : international medical journal of experimental and clinical research
  • Satoru Oka
  • ,
  • Yoko Obata
  • ,
  • Shuntaro Sato
  • ,
  • Kenta Torigoe
  • ,
  • Miki Sawa
  • ,
  • Shinichi Abe
  • ,
  • Kumiko Muta
  • ,
  • Yuki Ota
  • ,
  • Mineaki Kitamura
  • ,
  • Satoko Kawasaki
  • ,
  • Misaki Hirose
  • ,
  • Tadashi Uramatsu
  • ,
  • Hiroshi Mukae
  • ,
  • Tomoya Nishino

23
開始ページ
1464
終了ページ
1470
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.12659/msm.900693

BACKGROUND Endocan is expressed in vascular endothelial cells, and its expression is enhanced following endothelial injury via inflammatory cytokines. Subsequently, endocan is secreted into the circulation. Thus, serum endocan levels are considered a marker of endothelial injury. However, to the best of our knowledge, no data on the serum endocan levels in peritoneal dialysis (PD) patients are available. MATERIAL AND METHODS This study included 21 PD patients who underwent peritoneal equilibration test (PET) more than once between 2011 and 2015. Serum samples were collected from each patient, and the 24-h urine volume was measured at the time of PET. Serum endocan levels were measured using enzyme-linked immunosorbent assay (ELISA) at the time of the first PET, and their relationship with clinical data or the extent of urine volume decline (mL/year) was analyzed retrospectively. RESULTS Serum endocan levels were positively correlated with proteinuria level, serum creatinine level, serum tumor necrosis factor (TNF)-α level, β2-microglobulin level, and PD drainage volume, but not with urine volume at baseline. The extent of decline in urine volume was significantly associated with serum endocan level, proteinuria level, serum creatinine level, and serum TNF-α level at baseline in a simple linear regression analysis. Moreover, multiple linear regression analysis showed that the serum endocan level and proteinuria level at baseline were independent predictors for the extent of decline in urine volume. CONCLUSIONS The results of this study indicate that serum endocan level and proteinuria level may be useful predictive markers for decreased urine volume in PD patients.

リンク情報
DOI
https://doi.org/10.12659/msm.900693
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28343234
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380193

エクスポート
BibTeX RIS