2003年
5-HT7-like receptors mediate serotonergic modulation of photo-responsiveness of the medulla bilateral neurons in the cricket, Gryllus bimaculatus
Zoological Science
- ,
- 巻
- 20
- 号
- 3
- 開始ページ
- 303
- 終了ページ
- 309
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.2108/zsj.20.303
- 出版者・発行元
- ZOOLOGICAL SOC JAPAN
Serotonin (5-HT) suppresses the photo-responsiveness of medulla bilateral neurons (MBNs) that are involved in the coupling mechanism of the bilaterally paired optic lobe circadian pacemakers in the cricket, Gryllus bimaculatus. We found that forskolin, a highly specific activator of adenylate cyclase, mimicked the effects of serotonin on the MBNs. This fact suggests the involvement of cyclic 3', 5'-adenosine monophosphate (cAMP) in mediating the action of serotonin. We therefore tested the effects of various 5-HT receptor agonists and antagonists that are coupled to adenylate cyclase to specify the receptor involved. Application of 8-OH-DPAT that has affinity for both 5-HT1A and 5-HT7 receptors suppressed the photo-responsiveness, like forskolin. The inhibitory effect of 8-OH-DPAT was effectively blocked by clozapine, a high affinity 5-HT7 receptor antagonists with a very low affinity for 5-HT2. Ketanserin, a selective 5-HT2 antagonist, and NAN-190, a 5-HT1A antagonist, did not block it. These results suggest that serotonergic suppression of the photo-responsiveness of the MBNs is mediated by 5-HT7-like receptor subtypes.
- リンク情報
-
- DOI
- https://doi.org/10.2108/zsj.20.303
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000183807700003&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-0038462070&partnerID=MN8TOARS
- ID情報
-
- DOI : 10.2108/zsj.20.303
- ISSN : 0289-0003
- ORCIDのPut Code : 28249562
- SCOPUS ID : 0038462070
- Web of Science ID : WOS:000183807700003