久米広大 (Kodai Kume) - マイポータル

基本情報

所属: 広島大学原爆放射線医科学研究所分子疫学研究分野准教授

学位: 博士（医学）(香川大学)

研究者番号: 20592314
ORCID ID: https://orcid.org/0000-0001-9266-2543
J-GLOBAL ID: 201901017336268830
researchmap会員ID: B000369123

外部リンク: https://epidem.hiroshima-u.ac.jp/

研究テーマ：神経変性疾患の原因遺伝子の同定、病態の解明

ResearchGate

研究キーワード

研究分野

経歴

2021年4月 - 現在

広島大学原爆放射線医科学研究所, 分子疫学研究分野, 准教授
2020年4月 - 2021年3月

香川大学医学部自治体病院支援・推進医学講座, 客員准教授
2019年4月 - 2020年3月

広島大学原爆放射線医科学研究所, 分子疫学研究分野, 助教
2018年4月 - 2019年3月

広島大学原爆放射線医科学研究所, 分子疫学研究分野, 研究員
2014年6月 - 2018年3月

香川大学医学部, 総合内科, 病院助教
2010年4月 - 2014年5月

香川大学医学部, 消化器神経内科, 医員
2008年4月 - 2010年3月

香川大学医学部附属病院, 卒後臨床研修センター

学歴

2012年4月 - 2017年6月

香川大学, 大学院, 医学研究科
2002年4月 - 2008年3月

香川大学, 医学部, 医学科

主要な論文

C9orf72 repeat expansions in Wakayama: One potential cause of amyotrophic lateral sclerosis in the Kii Peninsula, Japan.

Seiji Emori, Kodai Kume, Yoshiaki Nakayama, Hidefumi Ito, Hideshi Kawakami

Journal of the neurological sciences 466 123209-123209 2024年9月1日責任著者
‘Raisin bread sign’ feature of pontine autosomal dominant microangiopathy and leukoencephalopathy

Mai Kikumoto, Takashi Kurashige, Tomohiko Ohshita, Kodai Kume, Osamu Kikumoto, Tomohisa Nezu, Shiro Aoki, Kazuhide Ochi, Hiroyuki Morino, Eiichi Nomura …

Brain Communications 2023年11月1日査読有り
CGG repeat expansion in LRP12 in amyotrophic lateral sclerosis.

Kodai Kume, Takashi Kurashige, Keiko Muguruma, Hiroyuki Morino, Yui Tada, Mai Kikumoto, Tatsuo Miyamoto, Silvia Natsuko Akutsu, Yukiko Matsuda, Shinya Matsuura …

American journal of human genetics 110(7) 1086-1097 2023年6月9日査読有り筆頭著者
Spinocerebellar ataxia type 17-digenic TBP/STUB1 disease: neuropathologic features of an autopsied patient

Rie Saito, Yui Tada, Daisuke Oikawa, Yusuke Sato, Makiko Seto, Akira Satoh, Kodai Kume, Nozomi Ueki, Masahiro Nakashima, Shintaro Hayashi …

Acta Neuropathologica Communications 10(1) 2022年12月7日査読有り
Comparison of two families with and without ataxia harboring novel variants in PRKCG.

Yui Tada, Kodai Kume, Soma Noguchi, Tomoko Sekiya, Kazuto Nishinaka, Hiroshi Ishiguchi, Jinsoo Koh, Seiji Emori, Yoshiaki Nakayama, Takashi Kurashige …

Journal of human genetics 67(10) 595-599 2022年6月28日査読有り責任著者
Novel monoallelic variant in ERLIN2 causes spastic paraplegia converted to amyotrophic lateral sclerosis.

Kodai Kume, Masaki Kamada, Yoshimitsu Shimatani, Tadayuki Takata, Yuishin Izumi, Hideshi Kawakami

Journal of the neurological sciences 430 119984-119984 2021年11月15日査読有り筆頭著者責任著者
FXTAS is difficult to differentiate from neuronal intranuclear inclusion disease through skin biopsy: a case report.

Megumi Toko, Tomohiko Ohshita, Takashi Kurashige, Hiroyuki Morino, Kodai Kume, Hiroshi Yamashita, Gen Sobue, Yasushi Iwasaki, Jun Sone, Hideshi Kawakami …

BMC neurology 21(1) 396-396 2021年10月12日査読有り
Analysis of genetic risk factors in Japanese patients with Parkinson's disease.

Yuhei Kanaya, Kodai Kume, Hiroyuki Morino, Ryosuke Ohsawa, Takashi Kurashige, Masaki Kamada, Tsuyoshi Torii, Yuishin Izumi, Hirofumi Maruyama, Hideshi Kawakami

Journal of human genetics 66(10) 957-964 2021年3月19日査読有り
Long-term MRI findings of adult-onset neuronal intranuclear inclusion disease.

Kisaki Tachi, Tadayuki Takata, Kodai Kume, Jun Sone, Hideki Kobara, Kazushi Deguchi, Hideshi Kawakami, Tsutomu Masaki

Clinical neurology and neurosurgery 201 106456-106456 2021年2月査読有り
The first Japanese case of primary familial brain calcification caused by an MYORG variant.

Kodai Kume, Tadayuki Takata, Hiroyuki Morino, Yukiko Matsuda, Ryosuke Ohsawa, Yui Tada, Takashi Kurashige, Hideshi Kawakami

Journal of human genetics 65(10) 917-920 2020年10月査読有り筆頭著者責任著者
Aggressive periodontitis and NOD2 variants.

Noriyoshi Mizuno, Kodai Kume, Yukiko Nagatani, Shinji Matsuda, Tomoyuki Iwata, Kazuhisa Ouhara, Mikihito Kajiya, Katsuhiro Takeda, Yukiko Matsuda, Yui Tada …

Journal of human genetics 65(10) 841-846 2020年10月査読有り
Optineurin regulates osteoblastogenesis through STAT1.

Noriyoshi Mizuno, Tomoyuki Iwata, Ryosuke Ohsawa, Kazuhisa Ouhara, Shinji Matsuda, Mikihito Kajiya, Yukiko Matsuda, Kodai Kume, Yui Tada, Hiroyuki Morino …

Biochemical and biophysical research communications 525(4) 889-894 2020年5月14日査読有り
Genetic screening for potassium channel mutations in Japanese autosomal dominant spinocerebellar ataxia.

Yui Tada, Kodai Kume, Yukiko Matsuda, Takashi Kurashige, Yuhei Kanaya, Ryosuke Ohsawa, Hiroyuki Morino, Hayato Tabu, Satoshi Kaneko, Toshihiko Suenaga …

Journal of human genetics 65(4) 363-369 2020年4月査読有り
Middle-age-onset cerebellar ataxia caused by a homozygous TWNK variant: a case report.

Kodai Kume, Hiroyuki Morino, Ryosuke Miyamoto, Yukiko Matsuda, Ryosuke Ohsawa, Yuhei Kanaya, Yui Tada, Takashi Kurashige, Hideshi Kawakami

BMC medical genetics 21(1) 68-68 2020年3月31日査読有り筆頭著者
Biallelic mutation of HSD17B4 induces middle age-onset spinocerebellar ataxia.

Yukiko Matsuda, Hiroyuki Morino, Ryosuke Miyamoto, Takashi Kurashige, Kodai Kume, Noriyoshi Mizuno, Yuhei Kanaya, Yui Tada, Ryosuke Ohsawa, Kazunori Yokota …

Neurology. Genetics 6(1) e396 2020年2月査読有り
Retinitis pigmentosa prior to familial ALS caused by a homozygous cilia and flagella-associated protein 410 mutation.

Takashi Kurashige, Hiroyuki Morino, Yukiko Matsuda, Tomoya Mukai, Tomomi Murao, Megumi Toko, Kodai Kume, Ryosuke Ohsawa, Tsuyoshi Torii, Hiroshi Tokinobu …

Journal of neurology, neurosurgery, and psychiatry 91(2) 220-222 2020年2月査読有り
Co-morbidity of progressive supranuclear palsy and amyotrophic lateral sclerosis: a clinical-pathological case report

Koji Fujita, Tomoyasu Matsubara, Ryosuke Miyamoto, Hiroyuki Sumikura, Toshiaki Takeuchi, Keiko Maruyama Saladini, Toshitaka Kawarai, Hiroyuki Nodera, Fukashi Udaka, Kodai Kume …

BMC Neurology 19(1) 168 2019年12月査読有り
C-terminal mutations in SYNE1 are associated with motor neuron disease in patients with SCAR8.

Kodai Kume, Hiroyuki Morino, Osamu Komure, Yukiko Matsuda, Ryosuke Ohsawa, Takashi Kurashige, Yuhei Kanaya, Yui Tada, Hideshi Kawakami

Journal of the neurological sciences 402 118-120 2019年7月15日査読有り筆頭著者
Three cases of non-carryover fingolimod-PML: Is the risk in Japan increased?

Jin Nakahara, Laura Tomaske, Kodai Kume, Tadayuki Takata, Masaki Kamada, Kazushi Deguchi, Kenji Kufukihara, Ruth Schneider, Ralf Gold, Ilya Ayzenberg

Neurology(R) neuroimmunology & neuroinflammation 6(3) e559 2019年5月査読有り筆頭著者
Clinical significance of assaying anti-MOG antibody in cerebrospinal fluid in MOG-antibody-associated diseases: A case report.

Shingo Aoe, Kodai Kume, Tadayuki Takata, Tetsuo Touge, Kimihiko Kaneko, Ichiro Nakashima, Kazushi Deguchi, Tsutomu Masaki

Multiple sclerosis and related disorders 28 165-166 2019年2月査読有り
Subacute Sensorimotor Neuropathy Accompanied by Anti-ganglioside GM1 Antibody in a Patient with Lung Cancer.

Kanaji N, Kume K, Mizoguchi H, Inoue T, Watanabe N, Nishiyama N, Kadowaki N, Ishii T

Internal medicine (Tokyo, Japan) 57(22) 3289-3292 2018年11月査読有り
Serum microRNA expression profiling in patients with multiple system atrophy.

Kodai Kume, Hisakazu Iwama, Kazushi Deguchi, Kazuyo Ikeda, Tadayuki Takata, Yohei Kokudo, Masaki Kamada, Keiko Fujikawa, Kayo Hirose, Hisashi Masugata …

Molecular medicine reports 17(1) 852-860 2018年1月査読有り筆頭著者
Effects of transcranial magnetic brain stimulation with the maximum voluntary muscle contraction (TMS with MVC) on cognitive and motor function in normal subjects

Kodai Kume

Journal of the Neurological Sciences 2017年
Acute Intermittent Porphyria Presenting with Posterior Reversible Encephalopathy Syndrome, Accompanied by Prolonged Vasoconstriction.

Tadayuki Takata, Kodai Kume, Yohei Kokudo, Kazuyo Ikeda, Masaki Kamada, Tetsuo Touge, Kazushi Deguchi, Tsutomu Masaki

Internal medicine (Tokyo, Japan) 56(6) 713-717 2017年査読有り
Dialysis-induced Subdural Hematoma in an Arachnoid Cyst Associated with Autosomal Dominant Polycystic Kidney Disease.

Tadayuki Takata, Yohei Kokudo, Kodai Kume, Kazuyo Ikeda, Masaki Kamada, Tetsuo Touge, Kazushi Deguchi, Tsutomu Masaki

Internal medicine (Tokyo, Japan) 55(15) 2065-7 2016年査読有り
Neuromyelitis optica spectrum disorder presenting with repeated hypersomnia due to involvement of the hypothalamus and hypothalamus-amygdala linkage.

Kodai Kume, Kazushi Deguchi, Kazuyo Ikeda, Tadayuki Takata, Yohei Kokudo, Masaki Kamada, Tetsuo Touge, Toshiyuki Takahashi, Takashi Kanbayashi, Tsutomu Masaki

Multiple sclerosis (Houndmills, Basingstoke, England) 21(7) 960-2 2015年6月査読有り筆頭著者
Significance of the hot-cross bun sign on T2*-weighted MRI for the diagnosis of multiple system atrophy.

Kazushi Deguchi, Kazuyo Ikeda, Kodai Kume, Tadayuki Takata, Yohei Kokudo, Masaki Kamada, Tetsuo Touge, Naomi Honjo, Tsutomu Masaki

Journal of neurology 262(6) 1433-9 2015年6月査読有り
Unilateral mydriatic tonic pupil as an early isolated symptom of neurosyphilis.

Tadayuki Takata, Masaki Kamada, Kazuyo Ikeda, Kodai Kume, Yohei Kokudo, Tetsuo Touge, Kazushi Deguchi, Tsutomu Masaki

Journal of the neurological sciences 344(1-2) 219-20 2014年9月15日査読有り
Usefulness of the modified F-ratio for assessments of proximal conduction in chronic inflammatory demyelinating polyneuropathy superimposed on Charcot Marie-Tooth disease type 1A.

Kodai Kume, Kazushi Deguchi, Kazuyo Ikeda, Tadayuki Takata, Yohei Kokudo, Masaki Kamada, Masago Tsukaguchi, Tetsuo Touge, Tsutomu Masaki

Journal of the neurological sciences 343(1-2) 237-9 2014年8月15日査読有り筆頭著者
Advantage of C-11-methionine positron emission tomography for assessing IgG4-related central nervous system lesions

Kodai Kume, Kazuyo Ikeda, Kazushi Deguchi, Masaki Kamada, Masaki Okada, Takashi Tamiya, Tetsuo Touge, Tsutomu Masaki

JOURNAL OF NEUROLOGY 261(3) 625-627 2014年3月査読有り筆頭著者
Nitric oxide-mediated modulation of calcium/calmodulin-dependent protein kinase II.

Tao Song, Naoya Hatano, Toshie Kambe, Yoshiaki Miyamoto, Hideshi Ihara, Hideyuki Yamamoto, Katsuyoshi Sugimoto, Kodai Kume, Fuminori Yamaguchi, Masaaki Tokuda …

The Biochemical journal 412(2) 223-31 2008年6月1日査読有り
p90 RSK-1 associates with and inhibits neuronal nitric oxide synthase.

Tao Song, Katsuyoshi Sugimoto, Hideshi Ihara, Akihiro Mizutani, Naoya Hatano, Kodai Kume, Toshie Kambe, Fuminori Yamaguchi, Masaaki Tokuda, Yasuo Watanabe

The Biochemical journal 401(2) 391-8 2007年1月15日査読有り
Inhibition of neuronal nitric-oxide synthase by phosphorylation at Threonine1296 in NG108-15 neuronal cells.

Tao Song, Naoya Hatano, Kodai Kume, Katsuyoshi Sugimoto, Fuminori Yamaguchi, Masaaki Tokuda, Yasuo Watanabe

FEBS letters 579(25) 5658-62 2005年10月24日査読有り