論文

2022年12月

Associations between salivary testosterone levels and cognitive function among 70‐year‐old Japanese elderly: A cross‐sectional analysis of the <scp>SONIC</scp> study

Geriatrics &amp; Gerontology International
  • Kumi Hirokawa
  • Ayaka Kasuga
  • Kiyoaki Matsumoto
  • Yasuko Omori
  • Yukie Masui
  • Takeshi Nakagawa
  • Madoka Ogawa
  • Yoshiko Ishioka
  • Hiroki Inagaki
  • Kazunori Ikebe
  • Yasumichi Arai
  • Tatsuro Ishizaki
  • Kei Kamide
  • Yasuyuki Gondo
  • 全て表示

22
12
開始ページ
1040
終了ページ
1046
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/ggi.14504
出版者・発行元
Wiley

Aim

This cross‐sectional study aimed to investigate the associations between salivary testosterone concentrations and cognitive function in 70‐year‐old Japanese elderly people without dementia and stroke.

Methods

Participants were 197 Japanese community‐dwelling people aged 69–71 years. Their salivary samples were collected, and their cognitive function was assessed using the Japanese version of the Montreal Cognitive Assessment (MoCA‐J). Participants were also administered a 10‐item recall and a 24‐item recognition test. The data for 179 (106 men and 73 women) individuals were analyzed, excluding individuals with a past history of stroke and dementia. Multivariate logistic regression analyses were performed after adjusting for lifestyle factors and analyzing data separately for men and women.

Results

MoCA‐J scores showed that men with low testosterone concentrations had a significantly greater risk of low cognitive performance than those with high testosterone concentrations (adjusted odds ratio: 4.72, 95% confidence interval: 1.06–21.00), while no significant association was found in women. The 10‐item recall test scores showed that higher testosterone concentrations were significantly associated with greater recall in the second trial in women (standardized beta = 0.24, P = 0.040), whereas no significant association was found in men. Salivary testosterone concentrations were positively associated with better cognitive performance in older men and women.

Conclusions

The associations between salivary testosterone concentrations and cognitive function were shown by different tasks for men and women. Geriatr Gerontol Int 2022; 22: 1040–1046.

リンク情報
DOI
https://doi.org/10.1111/ggi.14504
URL
https://onlinelibrary.wiley.com/doi/pdf/10.1111/ggi.14504
URL
https://onlinelibrary.wiley.com/doi/full-xml/10.1111/ggi.14504
ID情報
  • DOI : 10.1111/ggi.14504
  • ISSN : 1444-1586
  • eISSN : 1447-0594

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