2017年2月
Mblk-1 Transcription Factor Family: Its Roles in Various Animals and Regulation by NOL4 Splice Variants in Mammals
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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- 巻
- 18
- 号
- 2
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.3390/ijms18020246
- 出版者・発行元
- MDPI AG
Transcription factors play critical roles in regulation of neural development and functions. A transcription factor Mblk-1 was previously reported from a screen for factors possibly important for the higher brain functions of the honeybee. This review first summarizes how Mblk-1 was identified, and then provides an overview of the studies of Mblk-1 and their homologs. Mblk-1 family proteins are found broadly in animals and are shown to affect transcription activities. Studies have revealed that the mammalian homologs can interact with several cofactors and together regulate transcription. Interestingly, a recent study using the mouse homologs, Mlr1 and Mlr2, showed that one of their cofactor proteins, NOL4, have several splice variants with different effects on the transactivation activities of Mlr proteins. These findings suggest that there is an additional layer of the regulation of Mblk-1 family proteins by cofactor splice variants and provide novel insights into our current understanding of the roles of the conserved transcription factor family.
- リンク情報
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- DOI
- https://doi.org/10.3390/ijms18020246
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000395457700016&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-85011022881&partnerID=MN8TOARS
- URL
- http://orcid.org/0000-0002-6256-1335
- ID情報
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- DOI : 10.3390/ijms18020246
- ISSN : 1422-0067
- eISSN : 1422-0067
- ORCIDのPut Code : 34033672
- SCOPUS ID : 85011022881
- Web of Science ID : WOS:000395457700016