Apr, 2003
The regulation of bone resorption in tooth formation and eruption processes in mouse alveolar crest devoid of cathepsin K
JOURNAL OF PHARMACOLOGICAL SCIENCES
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- Volume
- 91
- Number
- 4
- First page
- 285
- Last page
- 294
- Language
- English
- Publishing type
- DOI
- 10.1254/jphs.91.285
- Publisher
- JAPANESE PHARMACOLOGICAL SOC
Osteoclastic bone resorption has recently been implicated in the tooth formation and eruption in alveolar bone. Cathepsin K (CK) is a cysteine proteinase expressed predominantly in osteoclasts and is believed to play a critical role in degradation of bone matrix proteins. Here we present evidence that the alveolar bone resorption is essential for the tooth formation and that eruption proceeds normally in CK-deficient (CK-/-) mice. Radiographic and histological analyses revealed that the alveolar bone from these animals had no significant abnormalities during the tooth development between 5 and 28 days after birth. The tooth crown was normally erupted through the alveolar bone layer at 28 days after birth. The number of tartrate-resistant acid phosphatase-positive multinuclear cells in the alveolar bone around the tooth germ was apparently increased in 5-day-old CK-/- mice compared with age-matched littermates. More important, however, the immunohistochemical localization of matrix metalloproteinase-9 (MMP-9) was clearly increased in the CK-/- osteoclasts. In contrast, no significant difference in the immunoreactivity for cathepsin D was observed between the CK-/- osteoclasts and the wild-type ones. These results indicate that CK-/- osteoclasts are fully differentiated and are capable of degrading the organic phase of alveolar bone during the tooth formation and eruption, which may result from the compensatory action by MMP-9 increasingly expressed in the osteoclasts.
- Link information
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- DOI
- https://doi.org/10.1254/jphs.91.285
- CiNii Articles
- http://ci.nii.ac.jp/naid/130000073687
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/12719657
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000182602200004&DestApp=WOS_CPL
- ID information
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- DOI : 10.1254/jphs.91.285
- ISSN : 1347-8613
- CiNii Articles ID : 130000073687
- Pubmed ID : 12719657
- Web of Science ID : WOS:000182602200004