Papers

Peer-reviewed International journal
Sep, 2018

HSP-enriched properties of extracellular vesicles involve survival of metastatic oral cancer cells.

Journal of cellular biochemistry
  • Kisho Ono
  • ,
  • Takanori Eguchi
  • ,
  • Chiharu Sogawa
  • ,
  • Stuart K Calderwood
  • ,
  • Junya Futagawa
  • ,
  • Tomonari Kasai
  • ,
  • Masaharu Seno
  • ,
  • Kuniaki Okamoto
  • ,
  • Akira Sasaki
  • ,
  • Ken-Ichi Kozaki

Volume
119
Number
9
First page
7350
Last page
7362
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1002/jcb.27039

Cancer cells often secrete extracellular vesicles (EVs) that carry heat shock proteins (HSPs) with roles in tumor progression. Oral squamous cell carcinoma (OSCC) belongs to head and neck cancers (HNC) whose lymph-node-metastases often lead to poor prognosis. We have examined the EV proteome of OSCC cells and found abundant secretion of HSP90-enriched EVs in lymph-node-metastatic OSCC cells. Double knockdown of HSP90α and HSP90β, using small interfering RNA significantly reduced the survival of the metastatic OSCC cells, although single knockdown of each HSP90 was ineffective. Elevated expression of these HSP90 family members was found to correlate with poor prognosis of HNC cases. Thus, elevated HSP90 levels in secreted vesicles are potential prognostic biomarkers and therapeutic targets in metastatic OSCC.

Link information
DOI
https://doi.org/10.1002/jcb.27039
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29768689
ID information
  • DOI : 10.1002/jcb.27039
  • Pubmed ID : 29768689

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