Hirofumi Kunitomo

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Affiliation: Graduate School of Science, The University of Tokyo

J-GLOBAL ID: 200901032844949186
researchmap Member ID: 1000292123

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Research Interests

Research Areas

Papers

Different modes of stimuli delivery elicit changes in glutamate driven, experience-dependent interneuron response in C. elegans.

Llian Mabardi, Hirofumi Sato, Yu Toyoshima, Yuichi Iino, Hirofumi Kunitomo

Neuroscience research, Oct 14, 2022
Simultaneous recording of behavioral and neural responses of free-moving nematodes C. elegans.

Hirofumi Sato, Hirofumi Kunitomo, Xianfeng Fei, Koichi Hashimoto, Yuichi Iino

STAR protocols, 2(4) 101011-101011, Dec 17, 2021
Glutamate signaling from a single sensory neuron mediates experience-dependent bidirectional behavior in Caenorhabditis elegans.

Hirofumi Sato, Hirofumi Kunitomo, Xianfeng Fei, Koichi Hashimoto, Yuichi Iino

Cell reports, 35(8) 109177-109177, May 25, 2021 Peer-reviewed
Roles of the ClC chloride channel CLH-1 in food-associated salt chemotaxis behavior of C. elegans.

Chanhyun Park, Yuki Sakurai, Hirofumi Sato, Shinji Kanda, Yuichi Iino, Hirofumi Kunitomo

eLife, 10, Jan 25, 2021 Peer-reviewedLast authorCorresponding author
Caenorhabditis Elegans Exhibits Morphine Addiction-like Behavior via the Opioid-like Receptor NPR-17.

Soichiro Ide, Hirofumi Kunitomo, Yuichi Iino, Kazutaka Ikeda

Frontiers in pharmacology, 12 802701-802701, 2021
Caenorhabditis elegans che-5 is allelic to gcy-22

Kunitomo, Hirofumi, Iino, Yuichi

microPublication Biology, 2020, Oct 8, 2020
Multiple sensory neurons mediate starvation-dependent aversive navigation in Caenorhabditis elegans.

Jang MS, Toyoshima Y, Tomioka M, Kunitomo H, Iino Y

Proceedings of the National Academy of Sciences of the United States of America, 116(37) 18673-18683, Aug, 2019 Peer-reviewedCorresponding author
線虫C.elegansのDAG/PKC経路による学習制御機構の解析

廣木進吾, 田村成宏, 富岡征大, 國友博文, 飯野雄一

生命科学系学会合同年次大会, 2017年度 [2LBA-111], Dec, 2017
A Gustatory Neural Circuit of Caenorhabditis elegans Generates Memory-Dependent Behaviors in Na+ Chemotaxis

Lifang Wang, Hirofumi Sato, Yohsuke Satoh, Masahiro Tomioka, Hirofumi Kunitomo, Yuichi Iino

JOURNAL OF NEUROSCIENCE, 37(8) 2097-2111, Feb, 2017 Peer-reviewed
Structural basis for Na+ transport mechanism by a light-driven Na+ pump

Hideaki E. Kato, Keiichi Inoue, Rei Abe-Yoshizumi, Yoshitaka Kato, Hikaru Ono, Masae Konno, Shoko Hososhima, Toru Ishizuka, Mohammad Razuanul Hoque, Hirofumi Kunitomo …

NATURE, 521(7550) 48-U347, May, 2015 Peer-reviewed
Regulation of Experience-Dependent Bidirectional Chemotaxis by a Neural Circuit Switch in Caenorhabditis elegans

Yohsuke Satoh, Hirofumi Sato, Hirofumi Kunitomo, Xianfeng Fei, Koichi Hashimoto, Yuichi Iino

JOURNAL OF NEUROSCIENCE, 34(47) 15631-15637, Nov, 2014 Peer-reviewed
Role of synaptic phosphatidylinositol 3-kinase in a behavioral learning response in C. elegans

Hayao Ohno, Shinya Kato, Yasuki Naito, Hirofumi Kunitomo, Masahiro Tomioka, Yuichi Iino

SCIENCE, 345(6194) 313-317, Jul, 2014 Peer-reviewed
Concentration memory-dependent synaptic plasticity of a taste circuit regulates salt concentration chemotaxis in Caenorhabditis elegans

Hirofumi Kunitomo, Hirofumi Sato, Ryo Iwata, Yohsuke Satoh, Hayao Ohno, Koji Yamada, Yuichi Iino

Nature Communications, 4 2210, 2013 Peer-reviewed
Roles for class IIA phosphatidylinositol transfer protein in neurotransmission and behavioral plasticity at the sensory neuron synapses of Caenorhabditis elegans

Ryo Iwata, Shigekazu Oda, Hirofumi Kunitomo, Yuichi Iino

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(18) 7589-7594, May, 2011 Peer-reviewed
Reversal of Salt Preference Is Directed by the Insulin/PI3K and G(q)/PKC Signaling in Caenorhabditis elegans

Takeshi Adachi, Hirofumi Kunitomo, Masahiro Tomioka, Hayao Ohno, Yoshifumi Okochi, Ikue Mori, Yuichi Iino

GENETICS, 186(4) 1309-U383, Dec, 2010 Peer-reviewed
Olfactory Plasticity Is Regulated by Pheromonal Signaling in Caenorhabditis elegans

Koji Yamada, Takaaki Hirotsu, Masahiro Matsuki, Rebecca A. Butcher, Masahiro Tomioka, Takeshi Ishihara, Jon Clardy, Hirofumi Kunitomo, Yuichi Iino

SCIENCE, 329(5999) 1647-1650, Sep, 2010 Peer-reviewed
Identification of Tubulin Deglutamylase among Caenorhabditis elegans and Mammalian Cytosolic Carboxypeptidases (CCPs)

Yoshishige Kimura, Nobuya Kurabe, Koji Ikegami, Koji Tsutsumi, Yoshiyuki Konishi, Oktay Ismail Kaplan, Hirofumi Kunitomo, Yuichi Iino, Oliver E. Blacque, Mitsutoshi Setou

JOURNAL OF BIOLOGICAL CHEMISTRY, 285(30) 22934-22939, Jul, 2010 Peer-reviewed
A reporter assay for G-protein-coupled receptors using a B-cell line suitable for stable episomal expression

Satoshi Saeki, Hirofumi Kunitomo, Yoshiyasu Narita, Hideki Mimura, Tatsunari Nishi, Katsutoshi Sasaki

ANALYTICAL BIOCHEMISTRY, 400(2) 163-172, May, 2010 Peer-reviewed
Single-cell transcriptional analysis of taste sensory neuron pair in Caenorhabditis elegans

Jun Takayama, Serge Faumont, Hirofumi Kunitomo, Shawn R. Lockery, Yuichi Iino

NUCLEIC ACIDS RESEARCH, 38(1) 131-142, Jan, 2010 Peer-reviewed
A trophic role for Wnt-Ror kinase signaling during developmental pruning in Caenorhabditis elegans

Yu Hayashi, Takaaki Hirotsu, Ryo Iwata, Eriko Kage-Nakadai, Hirofumi Kunitomo, Takeshi Ishihara, Yuichi Iino, Takeo Kubo

NATURE NEUROSCIENCE, 12(8) 981-U43, Aug, 2009 Peer-reviewed

Research History

2008

The University of Tokyo
2006 - 2007

Molecular Genetics Research Laboratory, The University of Tokyo
2007

助教, 遺伝子実験施設
2007

The University of Tokyo
1999 - 2006

Molecular Genetics Research Laboratory, The University of Tokyo

Misc.

線虫C.elegansのCLC型クロライドチャネルCLH-1の塩濃度走性における機能の解明

Park Chanhyun, 櫻井裕樹, 飯野雄一, 國友博文

生命科学系学会合同年次大会, 2017年度 [2P-1176], Dec, 2017
線虫C.elegansのDAG/PKC経路による学習制御機構の解析

廣木進吾, 田村成宏, 富岡征大, 國友博文, 飯野雄一

生命科学系学会合同年次大会, 2017年度 [2LBA-111], Dec, 2017
A neural circuit for memory-dependent Na+ Chemotaxis dissected in Caenorhabditis elegans

Lifang Wang, Hirofumi Sato, Yohsuke Satoh, Masahiro Tomioka, Hirofumi Kunitomo, Yuichi Iino

CHEMICAL SENSES, 41(9) E270-E270, Nov, 2016
線虫C.elegansのCIC型クロライドチャネルclh-1の塩走性学習における機能の解明

Park ChanHyun, 桜井裕樹, 飯野雄一, 國友博文

日本神経精神薬理学会年会プログラム・抄録集, 46回 240-240, Jul, 2016
【記憶ふたたび】線虫の微小神経回路による学習と記憶

國友博文, 飯野雄一

生体の科学, 67(1) 17-21, Feb, 2016
Learning and memory by the miniature neural circuit of C. elegans

國友博文, 飯野雄一

生体の科学, 67(1) 17-21, Jan, 2016
線虫の経験塩濃度依存的な行動を制御する神経回路の解明

SATO HIROFUMI, KUNITOMO HIROFUMI, FEI XIANFENG, HASHIMOTO KOICHI, IINO YUICHI

日本分子生物学会年会プログラム・要旨集(Web), 37th 1P-0685 (WEB ONLY), 2014
線虫C.elegansの塩濃度学習におけるモノアミン神経伝達物質の働き

KAWASAKI MIZUKI, KUNITOMO HIROFUMI, IINO YUICHI

日本分子生物学会年会プログラム・要旨集(Web), 37th 1P-0687 (WEB ONLY), 2014
線虫C.elegansを用いた塩走性学習の長期記憶形成

UEMURA MAI, IINO YUICHI, KUNITOMO HIROFUMI

日本分子生物学会年会プログラム・要旨集(Web), 37th 1P-0690 (WEB ONLY), 2014
線虫の化学走性の可塑性の分子神経機構

IINO YUICHI, ONO HAYAO, SATO HIROFUMI, SATO YOSUKE, TOMIOKA MASAHIRO, KUNITOMO HIROFUMI

日本動物学会大会予稿集, 84th 50, Aug 12, 2013
線虫C.elegansの塩濃度学習におけるモノアミン神経伝達物質の働き

KAWASAKI MIZUKI, KUNITOMO HIROFUMI, IINO YUICHI

日本分子生物学会年会プログラム・要旨集(Web), 36th 2P-0717 (WEB ONLY), 2013
線虫C.エレガンスの化学濃度勾配検出機構の光遺伝学的解析

SATO YOSUKE, KUNITOMO HIROFUMI, IINO YUICHI

日本分子生物学会年会プログラム・要旨集(Web), 35th 1P-0581 (WEB ONLY), 2012
A screen for Mutants with Reduced Number of Cilia in Caenorhabditis elegans

Adachi Takeshi, Nagahama Keigo, Kunitomo Hirofumi, Izumi Susumu

Science journal of Kanagawa University, 23 75-78, 2012
Axonal transport of a novel isoform of the Insulin/IGF receptor governs associative learning in Caenorhabditis elegans

Hayao Ohno, Masahiro Tomioka, Shinya Kato, Yasuki Naito, Hirofumi Kunitomo, Yuichi Iino

NEUROSCIENCE RESEARCH, 71 E279-E279, 2011
Molecular and neural mechanisms of behavioral plasticity based on salt taste memory in C. elegans

Hirofumi Kunitomo, Hirofumi Sato, Ryo Iwata, Takeshi Adachi, Hayao Ohno, Yuichi Iino

NEUROSCIENCE RESEARCH, 71 E40-E40, 2011
Ciliated sensory neurons of C. elegans are regulated by tubulin polyglutamylation in response to the environmental stresses

Yoshishige Kimura, Oktay Kaplan, Saira Hameed, Hirofumi Kunitomo, Yuichi Iino, Oliver Blacque, Mitsutoshi Setou

NEUROSCIENCE RESEARCH, 71 E47-E47, 2011
線虫C.elegansの塩濃度記憶に依存した神経応答の解析

SATO HIROFUMI, KUNITOMO HIROFUMI, ODA SHIGEKAZU, IINO YUICHI

日本分子生物学会年会プログラム・要旨集(Web), 34th 1P-0557 (WEB ONLY), 2011
線虫の塩濃度学習における情報統合の分子機構の解明

SAKAI NAOKO, TOMIOKA MASAHIRO, ADACHI TAKESHI, KUNITOMO HIROFUMI, IINO YUICHI

日本分子生物学会年会プログラム・要旨集(Web), 34th 1P-0556 (WEB ONLY), 2011
C.エレガンスの塩濃度走性の遺伝学的解析

SAKURAI YUKI, KUNITOMO HIROFUMI, IINO YUICHI

日本分子生物学会年会プログラム・要旨集(Web), 34th 1P-0555 (WEB ONLY), 2011
プロテインキナーゼCによる線虫の塩濃度学習の制御機構の解析

TAMURA SHIGEHIRO, TOMIOKA MASAHIRO, KUNITOMO HIROFUMI, IINO YUICHI

日本分子生物学会年会プログラム・要旨集(Web), 34th 1P-0559 (WEB ONLY), 2011

Books and Other Publications

線虫の神経可塑性におけるRas-MAPK経路及びインシュリン経路の機能の解明

飯野雄一, 國友博文

飯野雄一, 2005
神経系におけるRas-MAPキナーゼシグナル伝達経路の機能の解明

飯野雄一, 國友博文

飯野雄一, 2003

Research Projects

Mechanisms by which physiological stress modulates learning and memory

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
Comprehensive understanding of avoidance behavior caused by environmental sensing

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
Mechanisms of memory formation and generation of adaptive behavior

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2023
Molecular and neural mechanisms for a memory of sensory stimulus and behavioral choice

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2018

KUNITOMO Hirofumi, IINO Yuichi, SATO Hirofumi, PARK ChanH
Molecular neural mechanisms for behavioral modulation by inter-individual communication

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2018

IINO YUICHI, KUNITOMO Hirofumi, TOMIOKA Masahiro, TOYOSHIMA Yu, TSUCHIYA Jun-ichi, TORIYABE Hiroshi, YANAGI Shuichi
Discovery of new molecules involved in learning and memory and study of their mode of action

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jun, 2013 - Mar, 2018

IINO YUICHI, KUNITOMO Hirofumi, TOMIOKA Masahiro, TOYOSHIMA Yu, OHNO Hayao, Sato Hirofumi, WANG Lifang, MORI Keita, YANAGI Shuichi, SAKAI Naoko
神経回路の活動と行動の対応付けに基づく連合学習の神経機構の解明

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Jun, 2013 - Mar, 2015

國友博文
A study on the molecular and neural mechanisms of chemotaxis and associative learning

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, 2008 - 2012

IINO Yuichi, KUNITOMO Hirodfumi, TOMIOKA Masahiro
Functional genomics of the chemosensory neurons of C.elegans

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2007 - 2008

KUNITOMO Hirofumi, IINO Yuichi, TAKAYAMA Jun
A Study on the Function of Insulin Signaling Pathway in Associative Learning

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2007 - 2008

LINO Yuichi
行動スクリーニング系の開発

科学研究費助成事業, 萌芽研究, 日本学術振興会, 2006 - 2008

飯野雄一, 國友博文
線虫の化学走性学習に関わる分子パスウェイの機能解析

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2006 - 2007

飯野雄一, 國友博文
機能ゲノミクスによる感覚受容と神経機能に関わる遺伝子ネットワークの解明

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2006 - 2007

飯野雄一, 國友博文
神経可塑性を制御するシグナル伝達経路の機能解析

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2005 - 2005

飯野雄一, 國友博文
機能ゲノミクスと遺伝学的に手法による線虫の化学走性学習の分子機構の解明

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2005 - 2005

飯野雄一, 國友博文
神経細胞の個性を作り出す細胞種特異的遺伝子発現のゲノムレベルでの解析

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2004 - 2004

飯野雄一, 國友博文
Study of the functions of the Ras-MAPK pathway and the insulin pathway in neural plasticity of C. elegans

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2003 - 2004

IINO Yuichi, KUNITOMO Hirofumi
線虫の化学走性の可塑性に関わる神経回路と機能分子の同定

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2003 - 2004

飯野雄一, 國友博文
多細胞生物における細胞個性の解析のための研究手法の開発

科学研究費助成事業, 萌芽研究, 日本学術振興会, 2003 - 2003

飯野雄一, 國友博文
神経系における細胞個性の理解に向けての方法の開発とリソースの整備

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2003 - 2003

飯野雄一, 國友博文

Industrial Property Rights

特許第4294497号内分泌系細胞株とその利用法

佐々木克敏, 三浦和美, 佐伯智, 吉澤美佐子, 岸本和也, 國友博文, 西達也, 帯刀益夫
WO2003-087366 内分泌系細胞株とその利用法

佐々木克敏, 三浦和美, 佐伯智, 吉澤美佐子, 岸本和也, 國友博文, 西達也, 帯刀益夫
特開2003-038178 mRNA回収方法およびシステム

飯野雄一, 國友博文

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Research Interests

Research Areas

Papers

Research History

Misc.

Books and Other Publications

Research Projects

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