HIROKI KURAHASHI

J-GLOBAL         Last updated: Apr 12, 2019 at 11:29
 
Avatar
Name
HIROKI KURAHASHI
Nickname
kura
E-mail
kurafujita-hu.ac.jp
Affiliation
Fujita Health University
Section
Institute for Comprehensive Medical Science
Research funding number
30243215

Published Papers

 
Inagaki H, Ota S, Nishizawa H, Miyamura H, Nakahira K, Suzuki M, Nishiyama S, Kato T, Yanagihara I, Kurahashi H
Journal of human genetics   64(5) 459-466   May 2019   [Refereed]
Hitachi K, Nakatani M, Takasaki A, Ouchi Y, Uezumi A, Ageta H, Inagaki H, Kurahashi H, Tsuchida K
EMBO reports   20(3)    Mar 2019   [Refereed]
Yokoi K, Nakajima Y, Inagaki H, Tsutsumi M, Ito T, Kurahashi H
BMC medical genetics   19(1) 210   Dec 2018   [Refereed]
Ishihara N, Inagaki H, Miyake M, Kawamura Y, Yoshikawa T, Kurahashi H
Brain & development      Nov 2018   [Refereed]
Boda H, Miyata M, Inagaki H, Shinkai Y, Kato T, Yoshikawa T, Kurahashi H
European journal of medical genetics      Nov 2018   [Refereed]
Tsuchiya H, Akiyama T, Kuhara T, Nakajima Y, Ohse M, Kurahashi H, Kato T, Maeda Y, Yoshinaga H, Kobayashi K
Brain & development      Oct 2018   [Refereed]
Miura H, Kawamura Y, Hattori F, Kozawa K, Ihira M, Ohye T, Kurahashi H, Yoshikawa T
Journal of medical virology   90(10) 1636-1642   Oct 2018   [Refereed]
Ito M, Nishizawa H, Tsutsumi M, Kato A, Sakabe Y, Noda Y, Ohwaki A, Miyazaki J, Kato T, Shiogama K, Sekiya T, Kurahashi H, Fujii T
BMC medical genetics   19(1) 166   Sep 2018   [Refereed]
Hayano S, Okuno Y, Tsutsumi M, Inagaki H, Fukasawa Y, Kurahashi H, Kojima S, Takahashi Y, Kato T
International journal of cardiology      Sep 2018   [Refereed]
Suzumori N, Inagaki H, Ohtani A, Kumagai K, Takeda E, Yoshihara H, Sawada Y, Inuzuka S, Iwagaki S, Takahashi Y, Kurahashi H, Sugiura-Ogasawara M
European journal of obstetrics, gynecology, and reproductive biology      Sep 2018   [Refereed]

Misc

 
【先天異常症候群】 ピンポイント小児医療 染色体異常の発生メカニズム
加藤 武馬, 稲垣 秀人, 堤 真紀子, 倉橋 浩樹
小児内科   47(10) 1813-1815   Oct 2015   [Invited]
<Key Points>(1)染色体異常は数的異常と構造異常に分けられる。(2)数的異常は母親由来が多く、構造異常は父親由来が多い。(3)卵子形成過程で第一減数分裂の停止期間が長いことが、数的異常は女性由来が多く、加齢により頻度が増加する原因である。(4)精子形成過程で精原細胞の分裂回数が多いことが、構造異常や遺伝子変異は父親由来が多い原因である。(著者抄録)
【神経症候群(第2版)-その他の神経疾患を含めて-】 先天異常/先天奇形 染色体異常・先天奇形症候群 11/22混合トリソミー(Emanuel症候群)
大江 瑞恵, 倉橋 浩樹
日本臨床   別冊(神経症候群IV) 370-372   Sep 2014   [Invited]
【神経症候群(第2版)-その他の神経疾患を含めて-】 先天異常/先天奇形 染色体異常・先天奇形症候群 Cat eye症候群
大江 瑞恵, 倉橋 浩樹
日本臨床   別冊(神経症候群IV) 400-403   Sep 2014   [Invited]
【遺伝子医療の現状とゲノム医療の近未来】 ゲノム医療を支える技術開発 ゲノム構造解析の変革
稲垣 秀人, 倉橋 浩樹
医学のあゆみ   250(5) 331-335   Aug 2014
ゲノム構造解析の主体は顕微鏡下での観察によるG分染法やFISH解析からマイクロアレイ解析に移行し、微細なコピー数変動が高感度に検出できるようになった。マイクロアレイ解析は、新しいゲノム疾患の同定や、構造異常の発生メカニズムの解明に貢献したが、その一方で、ゲノムコピー数の量的解析という性質上、均衡型の構造異常が検出できず、用途が限定される。次世代シーケンス(NGS)技術は定量と定性が同時に可能であるという利点があり、マイクロアレイを凌駕する可能性を秘めている。近年、染色体破砕現象のような構造...
Positive and negative aspects of genetic testing for familial cancer
TAMAE OHYE, HIROKI KURAHASHI
Nihon Geka Gakkai Zasshi   115(1) 34-38   Jan 2014   [Invited]
[Single gene disorder].
Taniguchi M, Kurahashi H
Nihon rinsho. Japanese journal of clinical medicine   63 Suppl 12 57-63   Dec 2005   [Refereed]

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2007 - 2008    Investigator(s): Tamae OHYE
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2007 - 2008    Investigator(s): Hihiroki KURAHAS
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2004 - 2005    Investigator(s): Hiroki KURAHASHI
Constitutional t(11;22) is the only known recurrent non-Robertsonian translocation in humans. The breakpoints of t(11;22) are located within palindromic AT-rich repeats (PATRRs) on 11q23 and 22q11. I proposed that the PATRR forms cruciform structu...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2002 - 2003    Investigator(s): Hiroki KURAHASHI
Constitutional t(11;22) is the only known recurrent non-Robertsonian translocation in human. In my previous study, I demonstrated that the breakpoints of t(11;22) were located within palindromic AT-rich repeats. (PATRR). I proposed that the PATRR ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1998 - 1999    Investigator(s): Kumiko KOYAMA
1. We isolated a novel gene, APCL that showed significant homology to the adenomatous polyposis coli (APC) tumor suppressor gene. This novel gene located on chromosome 19p13.3, which region is STK11/LKB1 gene that cause of Peutz-Jeghers Syndrome (...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(C), 基盤研究(C))
Project Year: 1995 - 1996    Investigator(s): Hiroki KURAHASHI
Patients with several congenital anomaly syndrome, such as DiGeorge syndrome, conotruncal anomaly face syndrome, commonly have a deletion at 22q11. The acronym CATCH22 is now used for such syndromes, for they are thought to consist a contiguous ge...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(C))
Project Year: 1993 - 1994    Investigator(s): Hiroki KURAHASHI
The microdeletion in DiGeorge syndrome(DGS) and conotruncal anomaly face syndrome has been localized at 22q11. In order to iosolate responsible gene for these syndromes, cosmid library was constructed from the somatic cell hybrid containing human ...