Toshihide Kurihara

J-GLOBAL         Last updated: May 14, 2019 at 17:52
Toshihide Kurihara
Keio University
School of Medicine
Job title
Associate Professor
MD(University of Tsukuba), PhD(Keio University)
Other affiliation
The Scripps Research Institute


Toshihide Kurihara is an Associate Professor of Ophthalmology and a Principal Investigator for the Laboratory of Photobiologyat at Keio University, Tokyo, Japan. He received his M.D. degree from the Faculty of Medicine, University of Tsukuba, Ibaraki, Japan, in 2001. He completed his ophthalmology residency at Keio University Hospital in 2005, and obtained his Ph.D. degree under the supervision of Professor Kazuo Tsubota from Keio University Graduate School of Medicine in 2009. Dr. Kurihara did his postdoctoral training under the mentorship of Professor Martin Friedlander at the Scripps Research Institute in La Jolla, California, USA. His research interest is hypoxia responses in development, physiology, and pathophysiology of the retina. Currently, he also conducts research focusing on visual restoration utilizing optogenetics technology and molecular mechanism of myopia development and progression.

Editorial Board Member: BioMed Research International, Journal of Ophthalmology, and Case Reports in Ophthalmological Medicine

Research Areas


Academic & Professional Experience

Apr 2017
Project Associate Professor, School of Medicine, Keio University
Apr 2015
Mar 2017
Project Assistant Professor, Keio University School of Medicine
Apr 2015
Principal Investigator, Keio University, Center for Integrated Medical Research
Jul 2013
Jun 2014
Adjunct Assistant Professor, The Scripps Research Institute
Jul 2013
Mar 2015
Assistant Professor, Keio University School of Medicine
Apr 2012
Jun 2013
Adjunct Assistant Professor, Keio University School of Medicine
Dec 2009
Jun 2013
Research Associate, The Scripps Research Institute
Jul 2009
Nov 2009
Postdoctral fellow, University of California San Diego
Apr 2009
Mar 2012
Lecturer, Keio University School of Medicine
Apr 2005
Mar 2009
Research Asistant, Keio University School of Medicine


Apr 2005
Mar 2009
Graduate School of Medicine, Keio University
Apr 1995
Mar 2001
School of Medicine, University of Tsukuba

Awards & Honors

Jun 2016
Roles of hypoxia response in the retinal development and pathophysiology, Kitasato Award, Keio University School of Medicine
85th Kitasato Memorial Ceremony
Dec 2015
The 8th Tano Young Investigator's Award, Japanese Retina and Vitreous Society
Sep 2015
An association of serum vitamin D level with myopia initiation by UV exposure in chick, IMC International Travel Grant, International Myopia Conference
The 15th International Myopia Conference (IMC)
Jun 2015
Physiological function of vascular endothelial growth factor (VEGF) in the retina, Sanshikai Young Investigator Award, Keio University School of Medicine Alumni Association (Sanshikai)
May 2014
Neuronal VHL Deletion Induces Strong Suppression of Retinal Vascular Formation, ARVO/Alcon Early Career Clinician-Scientist Research Award, ARVO/Alcon Foundation
ARVO Annual Meeting 2014
Oct 2012
Age-related macular degeneration (AMD) induced by dysregulation of protein degradation and energy homeostasis via VHL-HIF axis, Future of Science Fund Scholarship, Keystone Symposia
Keystone Symposia Aging and Diseases of Aging 2012
Sep 2012
CRL2-VHL E3 ligase complex and age-related macular degeneration, 2nd Place Oral Presentation in Cell & Molecular Biology, Society of Fellows (SoF)
TSRI SoF Research Symposium 2012
Jul 2012
The role of von Hippel-Lindau tumor suppressor (VHL)-hypoxia-inducible factor (HIF) system in age-related macular degeneration, Young Investigator Travel Award, Fritz Tobler Foundation
XV International Symposium on Retinal Degeneration RD2012
Oct 2010
von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina, The 6th Young Investigator's Award 2010 of Alumni association of Keio University Department of Ophthalmology, Alumni association of Keio University Department of Ophthalmology
Annual meeting of Alumni association of Keio University Department of Ophthalmology 2010
Mar 2009
Physiological downregulation of HIF-1alpha is required for proper retinal vascular formation, Young Investigator's Award 2009 for Regenerative Medicine, Japanese Society for Regenerative Medicine
The 8th Congress of Japanese Society for Regenerative Medicine

Published Papers

Miwa Y, Hoshino Y, Shoda C, Jiang X, Tsubota K, Kurihara T
Neurochemistry International      Mar 2019   [Refereed]
Iyama C, Shigeno Y, Hirano E, Kamoshita M, Nagai N, Suzuki M, Minami S, Kurihara T, Sonobe H, Watanabe K, Shinoda H, Tsubota K, Ozawa Y
Scientific reports   9(1) 1010   Jan 2019   [Refereed]
Mori K, Kurihara T, Miyauchi M, Ishida A, Jiang X, Ikeda SI, Torii H, Tsubota K
Scientific Reports   9(1) 295   Jan 2019   [Refereed]
Jiang X, Kurihara T, Ikeda SI, Kunimi H, Mori K, Torii H, Tsubota K
Journal of Visualized Experiments   (143) e58822   Jan 2019   [Refereed]
Jiang X, Kurihara T, Torii H, Tsubota K
Eye & Contact Lens   44(5) 273-278   Sep 2018   [Refereed]
Morita Y, Miwa Y, Jounai K, Fujiwara D, Kurihara T, Kanauchi O
Nutrients   10(12) pii: E1991   Dec 2018   [Refereed]
Katada Y, Kobayashi K, Tsubota K, Kurihara T
PeerJ   7 e6317   Jan 2019   [Refereed]
Jiang X, Kurihara T, Kunimi H, Miyauchi M, Ikeda SI, Mori K, Tsubota K, Torii H, Tsubota K
Scientific Reports   8(1) 2026   Feb 2018   [Refereed]
Minami S, Nagai N, Suzuki M, Kurihara T, Sonobe H, Kamoshita M, Uchida A, Shinoda H, Takagi H, Sonoda S, Sakamoto T, Tsubota K, Ozawa Y
Scientific Reports   8(1) 58   Jan 2018   [Refereed]
Aketa N, Yamaguchi T, Asato T, Yagi-Yaguchi Y, Suzuki T, Higa K, Kurihara T, Satake Y, Tsubota K, Shimazaki J
American Journal of Ophthalmology   184 42-51   Dec 2017   [Refereed]


Toshihide Kurihara
Retina Medicine   4(2) 160-164   Oct 2015   [Invited]
Toshihide Kurihara
Ganka-Ophthalmology   57(8) 1027-1036   Jul 2015
Toshihide Kurihara
Ganka-Ophthalmology   57(2) 127-132   Feb 2015   [Invited]
Toshihide Kurihara
Ganka -Ophthalmology-   55(7) 787-793   Jul 2013   [Invited]
The Scripps Research Institute
News & Views   12(34)    Oct 2012   [Invited]
Toshihide Kurihara
The JSPS San Francisco Newsletter   (25)    Mar 2012   [Invited]
栗原 俊英, 石田 晋
Anti-aging medicine   3(4) 426-430   Nov 2007
KURIHARA Toshihide, NODA Kousuke, NODA Mika, NAGAI Norihiro, INOUE Makoto
眼科手術 = Journal of ophthalmic surgery   20(3) 379-381   Jul 2007

Conference Activities & Talks

Omega-3 polyunsaturated fatty acids suppressed experimental myopia progression in mice
Kiwako Mori, Toshihide Kurihara, Xiaoyan Jiang, Shin-ichi Ikeda, Makoto Arita, Hidemasa Torii,Kazuo Tsubota
ARVO 2019 Annual Meeting   2 May 2019   
Oral lactoferrin administration suppresses lens-induced myopia in mice
Shin-ichi Ikeda, Toshihide Kurihara, Xiaoyan Jiang, Masataro Toda, Kazuo Tsubota
ARVO 2019 Annual Meeting   2 May 2019   
Internal limiting membrane peeling may cause post-operative visual field defects in epiretinal membrane patients
Tomoki Kurihara, Kazuhiro Watanabe, Hideki Sonobe, Toshihide Kurihara, Norihiro Nagai, Hajime Shinoda, Kazuo Tsubota, Yoko Ozawa
ARVO 2019 Annual Meeting   2 May 2019   
Protective effect of a novel HIF inhibitor halofuginone in a murine model of retinal ischemia-reperfusion
Hiromitsu Kunim, Yukihiro Miwa, Yusaku Katada, Kazuo Tsubota, Toshihide Kurihara
ARVO 2019 Annual Meeting   1 May 2019   
Wavelength Specificity of Violet Light on Suppressing Refractive Change and Axial Elongation in A Murine Model of Lens-induced Myopia
Xiaoyan Jiang, Toshihide Kurihara, Kiwako Mori, Shin-ichi Ikeda Hidemasa Torii, Kazuo Tsubota
ARVO 2019 Annual Meeting   30 Apr 2019   
Detection of slight changes in the visual function using EvokeDx® system in healthy adults
Sakiko Minami, Norihiro Nagai, Misa Suzuki, Toshihide Kurihara, Mamoru Kamoshita, Hideki Sonobe, Kazuhiro Watanabe, Hajime Shinoda, Kazuo Tsubota, Yoko Ozawa
ARVO 2019 Annual Meeting   29 Apr 2019   
Efficacy of the newly invented Eyelid Clamper in ultra-wide-field fundus imaging
Nobuhiro Ozawa, Kiwako Mori, Yusaku Katada, Kazuo Tsubota, Toshihide Kurihara
ARVO 2019 Annual Meeting   29 Apr 2019   
Garcinia extract inhibiting HIF suppresses laser-induced CNV in mice
Mari Ibuki, Chiho Shoda, Yukihiro Miwa, Kazuo Tsubot, Toshihide Kurihara
ARVO 2019 Annual Meeting   28 Apr 2019   
HIF inhibitor topotecan suppresses choroidal neovascularization and fibroproliferation in mice
Chiho Shoda, Yukihiro Miwa, Ayako Ishida, Satoru Yamagami, Kazuo Tsubota, Toshihide Kurihara
ARVO 2019 Annual Meeting   28 Apr 2019   
Function of VEGF in development, physiology, and pathophysiology of the retina [Invited]
Toshihide Kurihara
The 123rd Annual Meeting of JOS   20 Apr 2019   

Research Grants & Projects

Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research (基盤研究(C)) ¥4,810,000-
Project Year: Apr 2015 - Mar 2018    Investigator(s): Toshihide Kurihara
Charitable Trust Fund for Ophthalmic Research in Commemoration of Santen Pharmaceutical’s Founder: Grant-in-aid for Scientific Research ¥2,000,000-
Project Year: 2015 - 2016    Investigator(s): Toshihide Kurihara
Visual Regeneration by Optogenetics
Takeda Science Foundation: Visionary Research in Medical Field ¥2,000,000-
Project Year: 2013 - 2015    Investigator(s): Toshihide Kurihara
Uehara Memorial Foundation: Grants-in-Aid for Scientific Research ¥2,000,000-
Project Year: 2013 - 2015    Investigator(s): Toshihide Kurihara
Japan Society for the Promotion of Science (JSPS): Postdoctral Fellowship for Research Abroad
Project Year: Jul 2011 - Jun 2013    Investigator(s): Toshihide Kurihara
The role of HIF in diabetic retinopathy
Kowa Life Science Foundation: Grant-in-aid for international exchange
Project Year: Jul 2009 - Jun 2011    Investigator(s): Toshihide Kurihara
The role of hypoxia-inducible factors (HIF) in diabetic retinopathy
Manpei Suzuki Diabetes Foundation: Postdoctoral fellowship for research abroad 2009
Project Year: Jul 2009 - Jun 2011    Investigator(s): Toshihide Kurihara
Involvement of a transcriptional factor HIF-1 in corneal transparency
Japan Eye Bank Association: Grant-in-Aid for Scientific Research Abroad
Project Year: Jul 2009 - Jun 2010    Investigator(s): Toshihide Kurihara
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research (若手研究(B))
Project Year: 2009 - 2010    Investigator(s): Toshihide Kurihara
Alumni Association of Keio University Department of Ophthalmology: Grant-in-Aid for Research Abroad
Project Year: 2010       Investigator(s): Toshihide Kurihara