2014年4月1日
Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice.
Scientific reports
- 巻
- 4
- 号
- 開始ページ
- 4548
- 終了ページ
- 4548
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/srep04548
Prevention of quality of life (QOL) deterioration is associated with the inhibition of geriatric diseases and the regulation of brain function. However, no substance is known that prevents the aging of both body and brain. It is known that polyamine concentrations in somatic tissues (including the brain) decrease with increasing age, and polyamine-rich foods enhance longevity in yeast, worms, flies, and mice, and protect flies from age-induced memory impairment. A main source of exogenous polyamines is the intestinal lumen, where they are produced by intestinal bacteria. We found that arginine intake increased the concentration of putrescine in the colon and increased levels of spermidine and spermine in the blood. Mice orally administered with arginine in combination with the probiotic bifidobacteria LKM512 long-term showed suppressed inflammation, improved longevity, and protection from age-induced memory impairment. This study shows that intake of arginine and LKM512 may prevent aging-dependent declines in QOL via the upregulation of polyamines.
- リンク情報
-
- DOI
- https://doi.org/10.1038/srep04548
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/24686447
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070089
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000333555300013&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.1038/srep04548
- ISSN : 2045-2322
- PubMed ID : 24686447
- PubMed Central 記事ID : PMC4070089
- Web of Science ID : WOS:000333555300013