MISC

2017年

Adipocyte death and chronic inflammation in obesity

Journal of Medical Investigation
  • Masashi Kuroda
  • ,
  • Hiroshi Sakaue

64
3-4
開始ページ
193
終了ページ
196
記述言語
英語
掲載種別
書評論文,書評,文献紹介等
DOI
10.2152/jmi.64.193
出版者・発行元
University of Tokushima

Cell death is closely linked to many diseases including cancer, neurodegenerative diseases, autoimmune diseases, and metabolic disorders. Increased adipocyte death has been reported during the development of obesity. Adipocyte death may be caused by excessive stress during obesity-related adipose tissue remodeling. Adipose tissue macrophages are key players in obesity-related inflammation and systemic insulin resistance. Accumulating evidence suggests that adipocyte death is involved in immune cell function and initiates inflammation through an interaction with macrophages
however, the precise mechanisms remain largely unknown. This review focuses on the contribution of dead cells (particularly dead adipocytes in adipose tissue) to the pathophysiological conditions associated with obesity.

リンク情報
DOI
https://doi.org/10.2152/jmi.64.193
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28954980
ID情報
  • DOI : 10.2152/jmi.64.193
  • ISSN : 1349-6867
  • ISSN : 1343-1420
  • PubMed ID : 28954980
  • SCOPUS ID : 85030235876

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