論文

国際誌
2020年10月4日

Imaging and manipulating the segmentation clock.

Cellular and molecular life sciences : CMLS
  • Kumiko Yoshioka-Kobayashi
  • ,
  • Ryoichiro Kageyama

記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00018-020-03655-z

During embryogenesis, the processes that control how cells differentiate and interact to form particular tissues and organs with precise timing and shape are of fundamental importance. One prominent example of such processes is vertebrate somitogenesis, which is governed by a molecular oscillator called the segmentation clock. The segmentation clock system is initiated in the presomitic mesoderm in which a set of genes and signaling pathways exhibit coordinated spatiotemporal dynamics to establish regularly spaced boundaries along the body axis; these boundaries provide a blueprint for the development of segment-like structures such as spines and skeletal muscles. The highly complex and dynamic nature of this in vivo event and the design principles and their regulation in both normal and abnormal embryogenesis are not fully understood. Recently, live-imaging has been used to quantitatively analyze the dynamics of selected components of the circuit, particularly in combination with well-designed experiments to perturb the system. Here, we review recent progress from studies using live imaging and manipulation, including attempts to recapitulate the segmentation clock in vitro. In combination with mathematical modeling, these techniques have become essential for disclosing novel aspects of the clock.

リンク情報
DOI
https://doi.org/10.1007/s00018-020-03655-z
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33015720
ID情報
  • DOI : 10.1007/s00018-020-03655-z
  • PubMed ID : 33015720

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