論文

国際誌
2020年9月18日

Species-specific segmentation clock periods are due to differential biochemical reaction speeds.

Science (New York, N.Y.)
  • Mitsuhiro Matsuda
  • ,
  • Hanako Hayashi
  • ,
  • Jordi Garcia-Ojalvo
  • ,
  • Kumiko Yoshioka-Kobayashi
  • ,
  • Ryoichiro Kageyama
  • ,
  • Yoshihiro Yamanaka
  • ,
  • Makoto Ikeya
  • ,
  • Junya Toguchida
  • ,
  • Cantas Alev
  • ,
  • Miki Ebisuya

369
6510
開始ページ
1450
終了ページ
1455
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1126/science.aba7668

Although mechanisms of embryonic development are similar between mice and humans, the time scale is generally slower in humans. To investigate these interspecies differences in development, we recapitulate murine and human segmentation clocks that display 2- to 3-hour and 5- to 6-hour oscillation periods, respectively. Our interspecies genome-swapping analyses indicate that the period difference is not due to sequence differences in the HES7 locus, the core gene of the segmentation clock. Instead, we demonstrate that multiple biochemical reactions of HES7, including the degradation and expression delays, are slower in human cells than they are in mouse cells. With the measured biochemical parameters, our mathematical model accounts for the two- to threefold period difference between the species. We propose that cell-autonomous differences in biochemical reaction speeds underlie temporal differences in development between species.

リンク情報
DOI
https://doi.org/10.1126/science.aba7668
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32943519
ID情報
  • DOI : 10.1126/science.aba7668
  • PubMed ID : 32943519

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