論文

国際誌
2020年5月6日

Methylation deficiency disrupts biological rhythms from bacteria to humans.

Communications biology
  • Jean-Michel Fustin
  • Shiqi Ye
  • Christin Rakers
  • Kensuke Kaneko
  • Kazuki Fukumoto
  • Mayu Yamano
  • Marijke Versteven
  • Ellen Grünewald
  • Samantha J Cargill
  • T Katherine Tamai
  • Yao Xu
  • Maria Luísa Jabbur
  • Rika Kojima
  • Melisa L Lamberti
  • Kumiko Yoshioka-Kobayashi
  • David Whitmore
  • Stephanie Tammam
  • P Lynne Howell
  • Ryoichiro Kageyama
  • Takuya Matsuo
  • Ralf Stanewsky
  • Diego A Golombek
  • Carl Hirschie Johnson
  • Hideaki Kakeya
  • Gerben van Ooijen
  • Hitoshi Okamura
  • 全て表示

3
1
開始ページ
211
終了ページ
211
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s42003-020-0942-0

The methyl cycle is a universal metabolic pathway providing methyl groups for the methylation of nuclei acids and proteins, regulating all aspects of cellular physiology. We have previously shown that methyl cycle inhibition in mammals strongly affects circadian rhythms. Since the methyl cycle and circadian clocks have evolved early during evolution and operate in organisms across the tree of life, we sought to determine whether the link between the two is also conserved. Here, we show that methyl cycle inhibition affects biological rhythms in species ranging from unicellular algae to humans, separated by more than 1 billion years of evolution. In contrast, the cyanobacterial clock is resistant to methyl cycle inhibition, although we demonstrate that methylations themselves regulate circadian rhythms in this organism. Mammalian cells with a rewired bacteria-like methyl cycle are protected, like cyanobacteria, from methyl cycle inhibition, providing interesting new possibilities for the treatment of methylation deficiencies.

リンク情報
DOI
https://doi.org/10.1038/s42003-020-0942-0
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32376902
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203018
ID情報
  • DOI : 10.1038/s42003-020-0942-0
  • PubMed ID : 32376902
  • PubMed Central 記事ID : PMC7203018

エクスポート
BibTeX RIS