2009年6月
Expression of canine Kdap in normal, hyperplastic and neoplastic epidermis.
Veterinary journal (London, England : 1997)
- 巻
- 180
- 号
- 3
- 開始ページ
- 348
- 終了ページ
- 55
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.tvjl.2008.01.006
- 出版者・発行元
- ELSEVIER SCI LTD
Keratinocyte differentiation-associated protein, Kdap, is a recently identified small secretory protein that may act as a soluble regulator for the cornification and/or desquamation of keratinocytes. To clarify the role of Kdap in the terminal differentiation of keratinocytes, detailed in situ localisation of Kdap was studied using canine skin with normal, hyperplastic and neoplastic epidermis. In normal canine trunk skin, Kdap was expressed by granular keratinocytes, with polarity to the apical side of the cells, suggesting that canine Kdap is present in lamellar granules, as in humans. Expression of Kdap was widespread in the spinous layers in hyperplastic epidermis, but was undetectable in squamous cell carcinomas. These findings suggest that Kdap is closely related to the delay of terminal differentiation and/or release of cells in hyperplastic epidermis.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.tvjl.2008.01.006
- ISSN : 1090-0233
- PubMed ID : 18691918
- Web of Science ID : WOS:000264897700012