We have been investigated the underlying mechanisms of adaptative sweat production to habitual exercise training. Our results briefly indicate that noradrenergic sympathetic nerve, alpha adrenergic stimulation, and L-type voltage gated Ca2+ channels could contribute to a high sweat production in habitually trained individuals. We also demonstrated that beta-adrenergic sweating is potentiated by an exposure to heat stress in which the response mediated by the co-activation of muscarinic acetylcholine receptors. Sex difference modulates adrenergic sweating. Collectively, these results developed some of the mechanisms of a high sweat production observed in habitually trained men.