バードリアム (Liam Baird) - マイポータル

基本情報

所属: 東北大学

研究者番号: 90724914
J-GLOBAL ID: 201801007153946941
researchmap会員ID: B000308861

研究分野

ライフサイエンス / 分子生物学 /

論文

NRF2 Activation by CDDO-Im Regulates Inflammatory and Autophagy Pathways in Human Microglial Cells

Ching-Tung Chu, Akira Uruno, Takafumi Suzuki, Keiko Taguchi, Liam Baird, Fumiki Katsuoka, Masayuki Yamamoto

Free Radical Biology and Medicine 2025年11月
Systemic activation of NRF2 contributes to the therapeutic efficacy of clinically-approved KRAS-G12C anti-cancer drugs.

Liam Baird, Lin Zhang, Takanori Hidaka, Lyu Xi, Ke Wang, Keiko Tateno, Tatsuro Iso, Takafumi Suzuki, Kazuki Kumada, Fumiki Katsuoka …

British journal of cancer 133(9) 1377-1390 2025年11月
The clinical-grade CBP/ p300 inhibitor CCS1477 represses the global NRF2-dependent cytoprotective transcription program and re-sensitizes cancer cells to chemotherapeutic drugs.

Ke Wang, Liam Baird, Masayuki Yamamoto

Free radical biology & medicine 233 102-117 2025年6月
Anticancer Effect of C19-Position Substituted Geldanamycin Derivatives Targeting NRF2-NQO1-activated Esophageal Squamous Cell Carcinoma.

Hiroyuki Oshikiri, Keiko Taguchi, Wataru Hirose, Yusuke Taniyama, Takashi Kamei, David Siegel, David Ross, Russell R A Kitson, Liam Baird, Masayuki Yamamoto

Molecular and cellular biology 45(2) 79-97 2025年
Sensor systems of KEAP1 uniquely detecting oxidative and electrophilic stresses separately In vivo

Miu Sato, Nahoko Yaguchi, Takuya Iijima, Aki Muramatsu, Liam Baird, Takafumi Suzuki, Masayuki Yamamoto

Redox Biology 2024年11月査読有り
Whole blood transcriptome analysis for age- and gender-specific gene expression profiling in Japanese individuals.

Yu-Ichi Aoki, Keiko Taguchi, Hayato Anzawa, Junko Kawashima, Noriko Ishida, Akihito Otuki, Atsushi Hasegawa, Liam Baird, Takafumi Suzuki, Ikuko N Motoike …

Journal of biochemistry 2024年1月24日
Immunoediting of KEAP1-NRF2 mutant tumours is required to circumvent NRF2-mediated immune surveillance

Liam Baird, Masayuki Yamamoto

Redox Biology 67 102904-102904 2023年11月
A NRF2-induced secretory phenotype activates immune surveillance to remove irreparably damaged cells

Liam Baird, Keiko Taguchi, Anqi Zhang, Yushi Takahashi, Takafumi Suzuki, Thomas W. Kensler, Masayuki Yamamoto

Redox Biology 66 102845-102845 2023年10月
Novel NRF2-activated cancer treatments utilizing synthetic lethality.

Liam Baird, Thomas W Kensler, Masayuki Yamamoto

IUBMB life 2022年10月5日
Halofuginone micelle nanoparticles eradicate Nrf2-activated lung adenocarcinoma without systemic toxicity.

Harit Panda, Mikiko Suzuki, Mitsuru Naito, Ritsumi Saito, Huaichun Wen, Liam Baird, Akira Uruno, Kanjiro Miyata, Masayuki Yamamoto

Free radical biology & medicine 187 92-104 2022年7月
NRF2-dependent bioactivation of mitomycin C as a novel strategy to target KEAP1-NRF2 pathway activation in human cancer.

Liam Baird, Masayuki Yamamoto

Molecular and cellular biology 41(2) 2020年11月2日
Geldanamycin-Derived HSP90 Inhibitors Are Synthetic Lethal with NRF2.

Liam Baird, Takafumi Suzuki, Yushi Takahashi, Eiji Hishinuma, Daisuke Saigusa, Masayuki Yamamoto

Molecular and cellular biology 40(22) 2020年10月26日
The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway.

Liam Baird, Masayuki Yamamoto

Molecular and cellular biology 40(13) 2020年6月15日
Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1.

Suzuki T, Muramatsu A, Saito R, Iso T, Shibata T, Kuwata K, Kawaguchi SI, Iwawaki T, Adachi S, Suda H …

Cell reports 28(3) 746-758 2019年7月16日査読有り
The Keap1-Nrf2 pathway: From mechanism to medical applications

Liam Baird, Masayuki Yamamoto

Oxidative Stress: Eustress and Distress 125-147 2019年1月1日
A Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis through Transcriptional Integration of Proteostatic Stress Response Pathways

Liam Baird, Tadayuki Tsujita, Eri H. Kobayashi, Ryo Funayama, Takeshi Nagashima, Keiko Nakayama, Masayuki Yamamoto

MOLECULAR AND CELLULAR BIOLOGY 37(4) E00651-U199 2017年2月査読有り
Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus

Takafumi Suzuki, Shiori Seki, Keiichiro Hiramoto, Eriko Naganuma, Eri H. Kobayashi, Ayaka Yamaoka, Liam Baird, Nobuyuki Takahashi, Hiroshi Sato, Masayuki Yamamoto

NATURE COMMUNICATIONS 8 14577 2017年2月査読有り
Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells

Tatsuro Iso, Takafumi Suzuki, Liam Baird, Masayuki Yamamoto

MOLECULAR AND CELLULAR BIOLOGY 36(24) 3100-3112 2016年12月査読有り
NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth

Hironori Satoh, Takashi Moriguchi, Daisuke Saigusa, Liam Baird, Lei Yu, Hirofumi Rokutan, Keiko Igarashi, Masahito Ebina, Tatsuhiro Shibata, Masayuki Yamamoto

CANCER RESEARCH 76(10) 3088-3096 2016年5月査読有り
Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response

Saito R, Suzuki T, Hiramoto K, Asami S, Naganuma E, Suda H, Iso T, Yamamoto H, Morita M, Baird L …

Mol Cell Biol 36(2) 271-284 2016年1月査読有り

もっとみる

共同研究・競争的資金等の研究課題

Keap1-Nrf2系によるストレス感知機構

日本学術振興会科学研究費助成事業若手研究(B) 2017年4月 - 2019年3月

鈴木隆史, 山本雅之, 磯達朗, 村松亜紀, 齋藤良太, 須田博美, 守田匡伸
An investigation into the mechanism regulating the oxidative stress-dependent activation of the Keap1-Nrf2 pathway

日本学術振興会科学研究費助成事業若手研究(B) 2016年4月 - 2019年3月

Baird Liam, 山本雅之, 鈴木隆史

バードリアム

基本情報

研究分野

論文

共同研究・競争的資金等の研究課題

メニュー

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