2015年7月
Comparative Analysis of Cartilage Marker Gene Expression Patterns during Axolotl and Xenopus Limb Regeneration
PLOS ONE
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- ,
- ,
- 巻
- 10
- 号
- 7
- 開始ページ
- e0133375
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1371/journal.pone.0133375
- 出版者・発行元
- PUBLIC LIBRARY SCIENCE
Axolotls (Ambystoma mexicanum) can completely regenerate lost limbs, whereas Xenopus laevis frogs cannot. During limb regeneration, a blastema is first formed at the amputation plane. It is thought that this regeneration blastema forms a limb by mechanisms similar to those of a developing embryonic limb bud. Furthermore, Xenopus laevis frogs can form a blastema after amputation; however, the blastema results in a terminal cone-shaped cartilaginous structure called a "spike." The causes of this patterning defect in Xenopus frog limb regeneration were explored. We hypothesized that differences in chondrogenesis may underlie the patterning defect. Thus, we focused on chondrogenesis. Chondrogenesis marker genes, type I and type II collagen, were compared in regenerative and nonregenerative environments. There were marked differences between axolotls and Xenopus in the expression pattern of these chondrogenesis-associated genes. The relative deficit in the chondrogenic capacity of Xenopus blastema cells may account for the absence of total limb regenerative capacity.
- リンク情報
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- DOI
- https://doi.org/10.1371/journal.pone.0133375
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201702204313536792
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/26186213
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000358198700130&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1371/journal.pone.0133375
- ISSN : 1932-6203
- J-Global ID : 201702204313536792
- PubMed ID : 26186213
- Web of Science ID : WOS:000358198700130