論文

査読有り 最終著者 責任著者
2012年10月

Early Regulation of Axolotl Limb Regeneration

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
  • Aki Makanae
  • ,
  • Akira Satoh

295
10
開始ページ
1566
終了ページ
1574
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/ar.22529
出版者・発行元
WILEY-BLACKWELL

Amphibian limb regeneration has been studied for a long time. In amphibian limb regeneration, an undifferentiated blastema is formed around the region damaged by amputation. The induction process of blastema formation has remained largely unknown because it is difficult to study the induction of limb regeneration. The recently developed accessory limb model (ALM) allows the investigation of limb induction and reveals early events of amphibian limb regeneration. The interaction between nerves and wound epidermis/epithelium is an important aspect of limb regeneration. During early limb regeneration, neurotrophic factors act on wound epithelium, leading to development of a functional epidermis/epithelium called the apical epithelial cap (AEC). AEC and nerves create a specific environment that inhibits wound healing and induces regeneration through blastema formation. It is suggested that FGF-signaling and MMP activities participate in creating a regenerative environment. To understand why urodele amphibians can create such a regenerative environment and humans cannot, it is necessary to identify the similarities and differences between regenerative and nonregenerative animals. Here we focus on ALM to consider limb regeneration from a new perspective and we also reported that focal adhesion kinase (FAK)Src signaling controlled fibroblasts migration in axolotl limb regeneration. Anat Rec, 2012. (c) 2012 Wiley Periodicals, Inc.

リンク情報
DOI
https://doi.org/10.1002/ar.22529
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/22933482
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000308638600006&DestApp=WOS_CPL
ID情報
  • DOI : 10.1002/ar.22529
  • ISSN : 1932-8486
  • eISSN : 1932-8494
  • PubMed ID : 22933482
  • Web of Science ID : WOS:000308638600006

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