Molecular communication is a bio-inspired communication paradigm using molecules as information carriers. In this paper, we built an example molecular communication system in aqueous media, which includes propagation of molecular capsules capable of carrying molecular information between a molecular sender and a molecular receiver and followed amplification of the information at the receiver. A gemini peptide lipid as a molecular switch embedded in the lipid bilayer membranes logically controlled propagation of molecular capsules formed with small liposomes from a sender to a receiver each composed of a giant liposome, with input signals, such as chemical, photonic, and thermal signals. In addition, the molecular switch acted as an artificial receptor at the receiver, receiving a photonic signal to communicate with an enzyme as a signal amplifier by using Cu2+ ion as a mediator between the receptor and the amplifier. © 2008 ICST 978-963-9799-35-6.