2017年7月
A longitudinal DTI and histological study of the spinal cord reveals early pathological alterations in G93A-SOD1 mouse model of amyotrophic lateral sclerosis
EXPERIMENTAL NEUROLOGY
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- 巻
- 293
- 号
- 開始ページ
- 43
- 終了ページ
- 52
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.expneurol.2017.03.018
- 出版者・発行元
- ACADEMIC PRESS INC ELSEVIER SCIENCE
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by selective motor neuron degeneration in the motor cortex, brainstem and spinal cord. It is generally accepted that ALS is caused by death of motor neurons, however the exact temporal cascade of degenerative processes is not yet completely known. To identify the early pathological changes in spinal cord of G93A-SOD1 AIS mice we performed a comprehensive longitudinal analysis employing diffusion-tensor magnetic resonance imaging alongside histology and electron microscopy, in parallel with peripheral nerve histology. We showed the gradient of degeneration appearance in spinal cord white and gray matter, starting earliest in the ventral white matter, due to a cascade of pathological events including axon dysfunction and mitochondrial changes. Notably, we found that even the main sensory regions are affected by the neurodegenerative process at symptomatic disease phase. Overall our results attest the applicability of DTI in determining disease progression in ALS mice. These findings suggest that DTI could be potentially adapted in humans to aid the assessment of ALS progression and eventually the evaluation of treatment efficacy. (C) 2017 Elsevier Inc. All rights reserved.
Web of Science ® 被引用回数 : 14
Web of Science ® の 関連論文(Related Records®)ビュー
- リンク情報
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- DOI
- https://doi.org/10.1016/j.expneurol.2017.03.018
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000401784300004&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-85016473519&partnerID=MN8TOARS
- URL
- http://orcid.org/0000-0002-2532-1674
- ID情報
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- DOI : 10.1016/j.expneurol.2017.03.018
- ISSN : 0014-4886
- eISSN : 1090-2430
- ORCIDのPut Code : 37534809
- SCOPUS ID : 85016473519
- Web of Science ID : WOS:000401784300004