2015年3月
In vivo quantitative magnetization transfer imaging correlates with histology during de- and remyelination in cuprizone-treated mice
NMR IN BIOMEDICINE
- 巻
- 28
- 号
- 3
- 開始ページ
- 327
- 終了ページ
- 337
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/nbm.3253
- 出版者・発行元
- WILEY-BLACKWELL
The pool size ratio measured by quantitative magnetization transfer MRI is hypothesized to closely reflect myelin density, but their relationship has so far been confirmed mostly in ex vivo conditions. We investigate the correspondence between this parameter measured in vivo at 7.0T, with Black Gold II staining for myelin fibres, and with myelin basic protein and beta-tubulin immunofluorescence in a hybrid longitudinal study of C57BL/6 and SJL/J mice treated with cuprizone, a neurotoxicant causing relatively selective myelin loss followed by spontaneous remyelination upon treatment suspension. Our results confirm that pool size ratio measurements correlate with myelin content, with the correlation coefficient depending on strain and staining method, and demonstrate the in vivo applicability of this MRI technique to experimental mouse models of multiple sclerosis. Copyright (c) 2015 John Wiley & Sons, Ltd.
- リンク情報
-
- DOI
- https://doi.org/10.1002/nbm.3253
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000350139800006&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-84924026903&partnerID=MN8TOARS
- URL
- http://orcid.org/0000-0002-2532-1674
- ID情報
-
- DOI : 10.1002/nbm.3253
- ISSN : 0952-3480
- eISSN : 1099-1492
- ORCIDのPut Code : 37534873
- SCOPUS ID : 84924026903
- Web of Science ID : WOS:000350139800006