Mika Higashide

Profile Information

ORCID ID: https://orcid.org/0000-0001-8682-135X
J-GLOBAL ID: 202001013764844875
researchmap Member ID: R000004207

Research Interests

Research Areas

Research History

Apr, 2023 - Present

JSPS Research Fellowship for Young Scientists (RPD), Faculty of Engineering, University of Fukui
Apr, 2020 - Present

Faculty of Engineering, University of Fukui
Apr, 2018 - Mar, 2020

Assistant professor, Institute for Protein Research, Osaka University
Apr, 2017 - Mar, 2018

Part-time researcher, Graduate School of Medicine , Dentistry and Pharmaceutical Sciences, Okayama University

Education

Apr, 2013 - Mar, 2017

Department of Biological Sciences, Graduate School of Science, Osaka University
Apr, 2011 - Mar, 2013

Department of Biological Sciences, Graduate School of Science, Osaka University
Apr, 2007 - Mar, 2011

Department of Biological Science, Faculty of Science, Nara Women's University

Papers

RPA interacts with Rad52 to promote meiotic crossover and noncrossover recombination

Jeong H Joo, Soogil Hong, Mika T Higashide, Eui-Hwan Choi, Seobin Yoon, Min-Su Lee, Hyun Ah Kang, Akira Shinohara, Nancy Kleckner, Keun P Kim

Nucleic Acids Research, Feb 10, 2024
Effects of Sugars on Giant Unilamellar Vesicle Preparation, Fusion, PCR in Liposomes, and Pore Formation

Kyoka Kajii, Ayu Shimomura, Mika T. Higashide, Masaya Oki, Gakushi Tsuji

Langmuir, Jul 14, 2022
The synaptonemal complex central region modulates crossover pathways and feedback control of meiotic double-strand break formation.

Lee MS, Higashide MT, Choi H, Li K, Hong S, Lee K, Shinohara A, Shinohara M, Keun P Kim

Nucleic acids research, 49(13) 7537-7553, Jul 1, 2021
Structure-based design of gRNA for Cas13.

Srinivas Bandaru, Mika Higashide Tsuji, Yurika Shimizu, Kaya Usami, Suni Lee, Naoko Kumagai Takei, Kei Yoshitome, Yasumitsu Nishimura, Takemi Otsuki, Tatsuo Ito

Scientific reports, 10(1) 11610-11610, Jul 14, 2020 Peer-reviewed
Dual roles of yeast Rad51 N-terminal domain in repairing DNA double-strand breaks.

Tai-Ting Woo, Chi-Ning Chuang, Mika Higashide, Akira Shinohara, Ting-Fang Wang

Nucleic acids research, 48(15) 8474-8489, Jul 11, 2020 Peer-reviewed
Meiosis-specific cohesin component, Rec8, promotes the localization of Mps3 SUN domain protein on the nuclear envelope.

Bommi, J.R, Prasada Rao, HBDP, Challa, K, Higashide, M, Shinmyozu, K, Nakayama, J, Shinohara, M, A. Shinohara

Genes to Cells : devoted to molecular & cellular mechanisms, 24(1) 94-106, Jan, 2019 Peer-reviewed
Meiosis-specific cohesin component, Rec8, promotes the localization of Mps3 SUN domain protein on the nuclear envelope.

JAGADEESWARA RAO BOMMI, Rao HBDP, kiran challa, Higashide M, Shinmyozu K, Jun-ichi Nakayama, Shinohara M, Akira Shinohara

Genes to cells : devoted to molecular & cellular mechanisms, Dec 12, 2018
Budding Yeast SLX4 Contributes to the Appropriate Distribution of Crossovers and Meiotic Double-Strand Break Formation on Bivalents During Meiosis.

Mika Higashide, Miki Shinohara

G3 (Bethesda, Md.), 6(7) 2033-42, Jul 7, 2016 Peer-reviewed
The MRX Complex Ensures NHEJ Fidelity through Multiple Pathways Including Xrs2-FHA-Dependent Tel1 Activation.

Daichi Iwasaki, Kayoko Hayashihara, Hiroki Shima, Mika Higashide, Masahiro Terasawa, Susan M Gasser, Miki Shinohara

PLoS genetics, 12(3) e1005942, Mar, 2016 Peer-reviewed
Cyclin-dependent kinase-dependent phosphorylation of Lif1 and Sae2 controls imprecise nonhomologous end joining accompanied by double-strand break resection.

Kenichiro Matsuzaki, Masahiro Terasawa, Daichi Iwasaki, Mika Higashide, Miki Shinohara

Genes to cells : devoted to molecular & cellular mechanisms, 17(6) 473-93, Jun, 2012 Peer-reviewed

Misc.

シナプトネマ複合体の中央領域は減数分裂期交差型組換え形成とDSB形成フィードバック制御に機能する

篠原美紀, 篠原美紀, 篠原美紀, 東出望花, 東出望花, 東出望花, 李珂, 李珂, 李珂

日本分子生物学会年会プログラム・要旨集(Web), 43rd, 2020
Slx4, multifunctional scaffold protein, functions for negative regulation of CO formation specific in centromere-proximal region and DSB distribution on entire chromosomes

Mika Higashide, Miki Shinohara

GENES & GENETIC SYSTEMS, 91(6) 355-355, Dec, 2016 Peer-reviewed
酵母Xrs2のFHAドメインはATM/Tel1の活性維持とKuのDSB単鎖末端からの解離に必要である

篠原美紀, 岩崎大地, 林原加代子, 東出望花, 寺澤匡博, Gasse Susan M.

日本放射線影響学会大会講演要旨集, 59回 24-24, Oct, 2016
Elongation of synaptonemal complex in meiosis regulates crossover numbers between homologs dependent on chromosome-size

Mika Higashide, Miki Shinohara

GENES & GENETIC SYSTEMS, 90(6) 389-389, Dec, 2015 Peer-reviewed
Gmc2, a novel synaptonemal complex component, regulates the number of crossovers between homologous chromosomes in meiosis

Mika Higashide, Miki Shinohara

GENES & GENETIC SYSTEMS, 89(6) 324-324, Dec, 2014 Peer-reviewed
A novel function of Slx4, structure-specific endonuclease regulator subunit, in meiotic prophase

Mika Higashide, Akira Shinohara, Miki Shinohara

GENES & GENETIC SYSTEMS, 88(6) 375-375, Dec, 2013 Peer-reviewed
A novel function of Slx4, a regulational subunit of several DNA structure specific endonucleases, in meiotic recombination in Saccharomyces cereviciae

Mika Higashide, Miki Shinohara

GENES & GENETIC SYSTEMS, 87(6) 437-437, Dec, 2012 Peer-reviewed

Research Projects

ヘテロクロマチン境界領域変動による転写誘導量を細胞集団で一定に維持する機構の解明

科学研究費助成事業, 若手研究, 日本学術振興会, Apr, 2023 - Mar, 2027

東出望花
染色体構造依存的なdilncRNA代謝によるDSB修復経路選択機構の解明

科学研究費助成事業, 特別研究員奨励費, 日本学術振興会, Apr, 2023 - Mar, 2026

東出望花

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