論文

査読有り
2016年2月

Investigation of age-related changes in brain activity during the divalent task-switching paradigm using functional MRI

NEUROSCIENCE RESEARCH
  • Mitsunobu Kunimi
  • ,
  • Sachiko Kiyama
  • ,
  • Toshiharu Nakai

103
開始ページ
18
終了ページ
26
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.neures.2015.06.011
出版者・発行元
ELSEVIER IRELAND LTD

This study compared the brain activation of young and older subjects during the use of the task-switching paradigm (TSP) at various task speeds to examine the relationship between task load and brain activation. Specifically, it attempted to examine whether the task load-dependent BOLD response gradient is a useful tool for functional magnetic resonance imaging-based assessments of age-related changes in cognitive function. We predicted that the extent of the activation of the brain regions responsible for task-set reconfiguration and the inhibition of task switching functions induced during the performance of a TSP-based task would vary according to age. Task difficulty was controlled by altering the inter-stimulus interval. Although similar brain regions were activated in both age groups, significant differences in the extent of the activation were detected between the young and older groups. In particular, some regions were activated in the older group, but not the young group. This study indicated that TSP-based task performance-induced activation of the brain regions linked to executive function increases with age and that the degree and pattern of such activation depend on the content and difficulty of the task being performed. This indicates that the age- and task difficulty-dependent augmentation of brain activation varies between brain regions. (C) 2015 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.neures.2015.06.011
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000371942800003&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.neures.2015.06.011
  • ISSN : 0168-0102
  • eISSN : 1872-8111
  • Web of Science ID : WOS:000371942800003

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