論文

査読有り 筆頭著者
2013年1月28日

A naked RNA heptamer targeting the human Bcl-2 mRNA induces apoptosis of HL60 leukemia cells

Cancer Letters
  • Masayuki Takahashi
  • ,
  • Reyad A. Elbarbary
  • ,
  • Aiko Nakashima
  • ,
  • Mayumi Abe
  • ,
  • Norihiro Watanabe
  • ,
  • Miwako Narita
  • ,
  • Masuhiro Takahashi
  • ,
  • Masato Tamura
  • ,
  • Tetsuo Yoshida
  • ,
  • Masayuki Nashimoto

328
2
開始ページ
362
終了ページ
368
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.canlet.2012.10.016

tRNase ZL-utilizing efficacious gene silencing is a gene control technology, which is based on the property that tRNase ZL can cleave any target RNA under the direction of an appropriate small guide RNA (sgRNA). To find therapeutic sgRNAs to cure hematological malignancies, we investigated behavior of heptamer-type sgRNA. We demonstrated that a heptamer, mh1(Bcl-2), which targets the human Bcl-2 mRNA, can be taken up by cells without any transfection reagents and that it can induce apoptosis of the leukemia cells. Mouse xenograft experiments showed that a median survival of the mh1(Bcl-2)-treated mice was longer than that of the control mice. © 2012 Elsevier Ireland Ltd.

リンク情報
DOI
https://doi.org/10.1016/j.canlet.2012.10.016
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23092557
URL
https://www.sciencedirect.com/science/article/pii/S0304383512006040?via%3Dihub
ID情報
  • DOI : 10.1016/j.canlet.2012.10.016
  • ISSN : 0304-3835
  • ISSN : 1872-7980
  • PubMed ID : 23092557
  • SCOPUS ID : 84870382135

エクスポート
BibTeX RIS