2013年6月
Metre-long cell-laden microfibres exhibit tissue morphologies and functions.
Nature materials
- 巻
- 12
- 号
- 6
- 開始ページ
- 584
- 終了ページ
- 90
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/nmat3606
- 出版者・発行元
- NATURE PUBLISHING GROUP
Artificial reconstruction of fibre-shaped cellular constructs could greatly contribute to tissue assembly in vitro. Here we show that, by using a microfluidic device with double-coaxial laminar flow, metre-long core-shell hydrogel microfibres encapsulating ECM proteins and differentiated cells or somatic stem cells can be fabricated, and that the microfibres reconstitute intrinsic morphologies and functions of living tissues. We also show that these functional fibres can be assembled, by weaving and reeling, into macroscopic cellular structures with various spatial patterns. Moreover, fibres encapsulating primary pancreatic islet cells and transplanted through a microcatheter into the subrenal capsular space of diabetic mice normalized blood glucose concentrations for about two weeks. These microfibres may find use as templates for the reconstruction of fibre-shaped functional tissues that mimic muscle fibres, blood vessels or nerve networks in vivo.
- リンク情報
- ID情報
-
- DOI : 10.1038/nmat3606
- ISSN : 1476-1122
- eISSN : 1476-4660
- PubMed ID : 23542870
- Web of Science ID : WOS:000319402200030