Maiko Higuchi

Profile Information

Affiliation: Associate Professor, College of Science, Rikkyo University

Degree: 博士（工学）(東京大学)

Researcher number: 30420235
J-GLOBAL ID: 201801006489939106
researchmap Member ID: 7000023374

Research Areas

Life sciences / Cell biology /

Research History

Apr, 2021 - Present

College of Science, Rikkyo University
Nov, 2017 - Mar, 2021

Assistant Professor, College of Science, RIKKYO UNIVERSITY
Apr, 2014 - Oct, 2017

助教, 薬学部, 東京大学
Jan, 2013 - Mar, 2014

研究員, Max Planck Institute for Heart and Lung Research
Jan, 2012 - Dec, 2012

研究員, University of California, San Francisco
Apr, 2007 - Dec, 2011

助教, 分子細胞生物学研究所, 東京大学
Sep, 2005 - Mar, 2007

助手, 分子細胞生物学研究所, 東京大学
Apr, 2003 - Aug, 2005

研究員, 分子細胞生物学研究所, 東京大学

Education

- Mar, 2003

Graduate School, Division of Engineering, The University of Tokyo
- Mar, 2000

Graduate School, Division of Engineering, The University of Tokyo
- Mar, 1998

Faculty of Engineering, The University of Tokyo

Papers

Maternal stress suppresses cell proliferation in the forebrain of zebrafish larvae

Maiko Higuchi

Genes to Cells, 25(5) 350-357, 2020 Peer-reviewed
PDK1-Akt pathway regulates radial neuronal migration and microtubules in the developing mouse neocortex

Yasuhiro Itoh, Maiko Higuchi, Koji Oishi, Yusuke Kishi, Tomohiko Okazaki, Hiroshi Sakai, Takaki Miyata, Kazunori Nakajima, Yukiko Gotoh

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(21) E2955-E2964, May, 2016 Peer-reviewed
The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response

Tomohiko Okazaki, Maiko Higuchi, Kohsuke Takeda, Kiyoko Iwatsuki-Horimoto, Maki Kiso, Makoto Miyagishi, Hideyuki Yanai, Atsushi Kato, Mitsutoshi Yoneyama, Takashi Fujita …

SCIENCE SIGNALING, 8(388) ra78, Aug, 2015 Peer-reviewed
NEDDylation controls the target specificity of E2F1 and apoptosis induction

I. Aoki, M. Higuchi, Y. Gotoh

ONCOGENE, 32(34) 3954-3964, Aug, 2013 Peer-reviewed
Mitochondrial localization of the antiviral signaling adaptor IPS-1 is important for its induction of caspase activation

Tomohiko Okazaki, Maiko Higuchi, Yukiko Gotoh

Genes to Cells, 18(6) 493-501, Jun, 2013 Peer-reviewed
Akt1 promotes focal adhesion disassembly and cell motility through phosphorylation of FAK in growth factor-stimulated cells

Maiko Higuchi, Rina Kihara, Tomohiko Okazaki, Ichiro Aoki, Shiro Suetsugu, Yukiko Gotoh

JOURNAL OF CELL SCIENCE, 126(3) 745-755, Feb, 2013 Peer-reviewed
Scaffolding function of PAK in the PDK1-Akt pathway

Maiko Higuchi, Keisuke Onishi, Chikako Kikuchi, Yukiko Gotoh

NATURE CELL BIOLOGY, 10(11) 1356-U257, Nov, 2008 Peer-reviewed
JNK phosphorylates synaptotagmin-4 and enhances Ca2+-evoked release.

Mori, Y, Higuchi, M, Hirabayashi, Y, Fukuda, M, Gotoh, Y

EMBO J., 27(1) 76-87, Jan 9, 2008 Peer-reviewed
The PI3K-Akt pathway promotes microtubule stabilization in migrating fibroblasts.

Onishi K, Higuchi M, Asakura T, Masuyama N, Gotoh Y

Genes to cells : devoted to molecular & cellular mechanisms, 12(4) 535-546, Apr, 2007 Peer-reviewed
Adenosine A2A receptor facilitates calcium-dependent protein secretion through the activation of protein kinase A and phosphatidylinositol-3 kinase in PC12 cells.

Mori Y, Higuchi M, Masuyama N, Gotoh Y

Cell structure and function, 29(4) 101-110, Dec, 2004 Peer-reviewed
The phosphatidylinositol-3 kinase (PI3K)-Akt pathway suppresses neurite branch formation in NGF-treated PC12 cells.

Higuchi M, Onishi K, Masuyama N, Gotoh Y

Genes to cells : devoted to molecular & cellular mechanisms, 8(8) 657-669, Aug, 2003 Peer-reviewed
Hydrolysis of Diribonucleoside Monophosphate Diesters Assisted by a Manganese(II) Complex

Morio Yashiro, Maiko Higuchi, Makoto Komiyama, Youichi Ishii

Bulletin of the Chemical Society of Japan, 76(9) 1813-1817, 2003 Peer-reviewed
Effect of Alkaline Earth Metal Ions on the Phosphodiester Hydrolysis of RNA

Morio Yashiro, Maiko Higuchi, Yusuke Washizu, Makoto Komiyama

Bulletin of the Chemical Society of Japan, 75(8) 1843-1844, 2002 Peer-reviewed
SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling

Masahiro Shinohara, Yoh Terada, Akihiro Iwamatsu, Azusa Shinohara, Naoki Mochizuki, Maiko Higuchi, Yukiko Gotoh, Sayoko Ihara, Satoshi Nagata, Hiroshi Itoh …

Nature, 416(6882) 759-763, 2002 Peer-reviewed
Akt mediates Rac/Cdc42-regulated cell motility in growth factor-stimulated cells and in invasive PTEN knockout cells

Maiko Higuchi, Norihisa Masuyama, Yasuhisa Fukui, Akira Suzuki, Yukiko Gotoh

Current Biology, 11(24) 1958-1962, 2001 Peer-reviewed

Misc.

Metatranscriptome analyses indicate resource partitioning between diatoms in the field (vol 112, pg E2182, 2015)

Yasuhiro Itoh, Maiko Higuchi, Koji Oishi, Yusuke Kishi, Tomohiko Okazaki, Hiroshi Sakai, Takaki Miyata, Kazunori Nakajima, Yukiko Gotoh

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(25) E3587-E3587, Jun, 2016
PIキナーゼ-Akt経路

樋口麻衣子

生体の科学, 2015 Invited
新規翻訳後修飾による抗ウイルス応答分子IPS-1の機能の使い分け

岡崎朋彦, 樋口麻衣子, 後藤由季子

生化学, 2011
新規翻訳後修飾による抗ウイルス応答分子IPS-1の機能の使い分け

岡崎朋彦, 樋口麻衣子, 後藤由季子

日本Cell Death学会学術集会プログラム抄録集, 20th, 2011
JNK/p38MAPK経路によるウイルス応答制御メカニズム

岡崎朋彦, 樋口麻衣子, 武田弘資, 宮岸真, 加藤篤, 米山光俊, 藤田尚志, 一條秀憲, 後藤由季子

生化学, 2009
スキャフォールド分子PAKによるAktの選択的機能制御

樋口麻衣子, 大西啓介, 後藤由季子

実験医学, 2009
Aktの活性化因子と哺乳類における機能

樋口麻衣子, 後藤由季子

実験医学, 2005
PI3K-Akt経路による癌の悪性化

樋口麻衣子, 後藤由季子

実験医学, 2003

Research Projects

Regulation of cell cycle-dependent microtubule dynamics by the Akt1-EB2/RP1 signaling pathway

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
Akt-EB2/RP1による微小管動態の新規制御メカニズムと細胞極性制御

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2018

樋口麻衣子
原癌遺伝子Aktによる微小管安定化を介した細胞極性制御メカニズムの解明

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2015 - Mar, 2018

樋口麻衣子
スーパー制限酵素を用いたゲノム・マニュピュレーション工学の創成

科学研究費助成事業, 特別推進研究, 日本学術振興会, Apr, 2010 - Mar, 2015

小宮山真
原癌遺伝子Aktによる細胞極性制御メカニズムの解明

科学研究費助成事業, 若手研究(B), 日本学術振興会, Apr, 2011 - Mar, 2012

樋口麻衣子
原癌遺伝子Aktの選択的機能制御と創薬への応用

科学研究費助成事業, 若手研究(B), 日本学術振興会, Apr, 2008 - Mar, 2009

樋口麻衣子
Akt経路のよる癌悪性化メカニズムの解明と創薬への応用

科学研究費助成事業, 若手研究(B), 日本学術振興会, Apr, 2006 - Mar, 2007

樋口麻衣子

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