Apr, 2016 - Mar, 2020
analysis of susceptibility gene for deafness onset by platinum drug
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B) Grant-in-Aid for Young Scientists (B)
- Grant number
- 16K20291
- Japan Grant Number (JGN)
- JP16K20291
- Authorship
- Principal investigator
- Grant amount
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- (Total)
- 2,990,000 Japanese Yen
- (Direct funding)
- 2,300,000 Japanese Yen
- (Indirect funding)
- 690,000 Japanese Yen
Platinum drug used for pediatric solid tumors cause hearing loss and cause language delay in children. Recently, it has been reported overseas that hearing loss due to platinum drug may be due to susceptible genes rather than the effect of cumulative drug dose, but genetic mutations in Japanese are not yet clear. The purpose of this study was to discover a gene mutation susceptible to hearing loss caused by platinum.
From the analysis results, in Japanese, we searched for three risk polymorphisms reported, but there was no association with deafness, suggesting the existence of another polymorphism.
From the analysis results, in Japanese, we searched for three risk polymorphisms reported, but there was no association with deafness, suggesting the existence of another polymorphism.
- Link information
- ID information
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- Grant number : 16K20291
- Japan Grant Number (JGN) : JP16K20291